Moldovan George-Lucian相关文献与解析，生知库

Genome-wide CRISPR screens identify the EXO1-CAF-1 pathway suppressing R-loop-associated DNA damage.

全基因组 CRISPR 筛选发现 EXO1-CAF-1 通路可抑制 R 环相关的 DNA 损伤。

期刊:Nucleic Acids Research

影响因子:13.1

doi:10.1093/nar/gkag226

Nusawardhana Alexandra, Hale Anastasia, Straka Joshua, Nicolae Claudia M, Moldovan George-Lucian

Understanding single stranded DNA gaps: from formation to fate

了解单链DNA缺口：从形成到命运

期刊:Biochemical Journal

影响因子:4.3

doi:10.1042/BCJ20253455

Garg, Sonal; Moldovan, George-Lucian

发表日期：2026

文献求助收藏

The Zinc-Finger Protein POGZ Associates with Polycomb Repressive Complex 1 to Regulate Bone Morphogenetic Protein Signaling During Neuronal Differentiation.

锌指蛋白 POGZ 与多梳抑制复合物 1 结合，在神经元分化过程中调节骨形态发生蛋白信号传导。

期刊:Stem Cell Reviews and Reports

影响因子:4.2

doi:10.1007/s12015-025-11028-x

Chavez Jessenia, Wolf Trevor, Espana Cynthia Lascarez, Geng Zhuangzhuang, Tai Yen Teng, Flanagan John, Moldovan George-Lucian, Stafford James, Gao Zhonghua

The RRM domains of PARP14 mediate replication fork degradation in BRCA2-deficient cells.

PARP14 的 RRM 结构域介导 BRCA2 缺陷细胞中的复制叉降解。

期刊:NAR Cancer

影响因子:3.2

doi:10.1093/narcan/zcag005

Hale Anastasia, Lynch Katie A, Dhoonmoon Ashna, Nicolae Claudia M, Moldovan George-Lucian

Genome-wide CRISPR screens identify DNA repair and R-loop suppression as regulators of the cellular sensitivity to environmentally relevant Bisphenol A exposure

全基因组 CRISPR 筛选发现 DNA 修复和 R 环抑制是细胞对环境相关双酚 A 暴露敏感性的调节因子

期刊:

影响因子:

doi:10.64898/2026.04.13.718249

Hale, Anastasia; Nusawardhana, Alexandra; Straka, Joshua; Nicolae, Claudia M; Moldovan, George-Lucian

细胞生物学

发表日期：2026

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Translesion-synthesis-mediated bypass of DNA lesions occurs predominantly behind replication forks restarted by PrimPol.

跨损伤合成介导的 DNA 损伤绕过主要发生在由 PrimPol 重新启动的复制叉之后

期刊:Cell Reports

影响因子:6.9

doi:10.1016/j.celrep.2025.115360

Dhoonmoon Ashna, Ambrose Julia R, Garg Sonal, Lascarez-Espana Cynthia, Rebok Abbey, Spratt Thomas E, Moldovan George-Lucian, Nicolae Claudia M

毒理研究

发表日期：2025

文献求助收藏

Novel insights into the role of bisphenol A (BPA) in genomic instability

对双酚A（BPA）在基因组不稳定性中的作用的新见解

期刊:NAR Cancer

影响因子:3.2

doi:10.1093/narcan/zcae038

Hale, Anastasia; Moldovan, George-Lucian

发表日期：2024

文献求助收藏

Mechanisms of PARP1 inhibitor resistance and their implications for cancer treatment

PARP1抑制剂耐药机制及其对癌症治疗的影响

期刊:NAR Cancer

影响因子:3.2

doi:10.1093/narcan/zcac042

Jackson, Lindsey M; Moldovan, George-Lucian

CRISPR screens guide the way for PARP and ATR inhibitor biomarker discovery

CRISPR筛选为PARP和ATR抑制剂生物标志物的发现指明了方向。

期刊:

影响因子:

doi:10.1111/febs.16217

Schleicher, Emily M; Moldovan, George-Lucian

The nuclease EXO1 promotes genomic instability by degrading nascent DNA in BRCA-proficient cells.

核酸酶 EXO1 通过降解 BRCA 功能正常细胞中的新生 DNA 来促进基因组不稳定。

Genome-wide CRISPR screens identify the EXO1-CAF-1 pathway suppressing R-loop-associated DNA damage.

全基因组 CRISPR 筛选发现 EXO1-CAF-1 通路可抑制 R 环相关的 DNA 损伤。

Understanding single stranded DNA gaps: from formation to fate

了解单链DNA缺口：从形成到命运

The Zinc-Finger Protein POGZ Associates with Polycomb Repressive Complex 1 to Regulate Bone Morphogenetic Protein Signaling During Neuronal Differentiation.

锌指蛋白 POGZ 与多梳抑制复合物 1 结合，在神经元分化过程中调节骨形态发生蛋白信号传导。

The RRM domains of PARP14 mediate replication fork degradation in BRCA2-deficient cells.

PARP14 的 RRM 结构域介导 BRCA2 缺陷细胞中的复制叉降解。

Genome-wide CRISPR screens identify DNA repair and R-loop suppression as regulators of the cellular sensitivity to environmentally relevant Bisphenol A exposure

全基因组 CRISPR 筛选发现 DNA 修复和 R 环抑制是细胞对环境相关双酚 A 暴露敏感性的调节因子

Translesion-synthesis-mediated bypass of DNA lesions occurs predominantly behind replication forks restarted by PrimPol.

跨损伤合成介导的 DNA 损伤绕过主要发生在由 PrimPol 重新启动的复制叉之后

Novel insights into the role of bisphenol A (BPA) in genomic instability

对双酚A（BPA）在基因组不稳定性中的作用的新见解

Mechanisms of PARP1 inhibitor resistance and their implications for cancer treatment

PARP1抑制剂耐药机制及其对癌症治疗的影响

CRISPR screens guide the way for PARP and ATR inhibitor biomarker discovery

CRISPR筛选为PARP和ATR抑制剂生物标志物的发现指明了方向。