日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Pax6 limits the competence of developing cerebral cortical cells to respond to inductive intercellular signals

Pax6 限制发育中的大脑皮层细胞对诱导细胞间信号作出反应的能力

Martine Manuel, Kai Boon Tan, Zrinko Kozic, Michael Molinek, Tiago Sena Marcos, Maizatul Fazilah Abd Razak, Dániel Dobolyi, Ross Dobie, Beth E P Henderson, Neil C Henderson, Wai Kit Chan, Michael I Daw, John O Mason, David J Price

Pax6 is required intrinsically by thalamic progenitors for the normal molecular patterning of thalamic neurons but not the growth and guidance of their axons

丘脑祖细胞本质上需要 Pax6 来维持丘脑神经元的正常分子模式,但不需要 Pax6 来维持其轴突的生长和引导

James M Clegg, Ziwen Li, Michael Molinek, Isabel Martín Caballero, Martine N Manuel, David J Price

Cell-autonomous repression of Shh by transcription factor Pax6 regulates diencephalic patterning by controlling the central diencephalic organizer

转录因子 Pax6 对 Shh 的细胞自主抑制通过控制中枢间脑组织者来调节间脑模式

Isabel Martín Caballero, Martine N Manuel, Michael Molinek, Idoia Quintana-Urzainqui, Da Mi, Tomomi Shimogori, David J Price

Novel lines of Pax6-/- embryonic stem cells exhibit reduced neurogenic capacity without loss of viability

新型Pax6-/-胚胎干细胞系表现出神经发生能力降低,但细胞活力未丧失。

Quinn, Jane C; Molinek, Michael; Nowakowski, Tomasz J; Mason, John O; Price, David J

Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization

体内控制 Pax6 的过度表达会对 Pax6 基因座进行负向自我调节,导致晚期皮质祖细胞增殖的细胞自主缺陷,而对皮质区域化影响不大

Martine Manuel, Petrina A Georgala, Catherine B Carr, Simon Chanas, Dirk A Kleinjan, Ben Martynoga, John O Mason, Michael Molinek, Jeni Pinson, Thomas Pratt, Jane C Quinn, T Ian Simpson, David A Tyas, Veronica van Heyningen, John D West, David J Price