日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting the contact system in a rabbit model of extracorporeal membrane oxygenation

以兔体外膜肺氧合模型为靶点,研究接触系统

Tweddell, James S; Kharnaf, Mousa; Zafar, Farhan; Riggs, Kyle W; Reagor, James A; Monia, Brett P; Revenko, Alexey; Leino, Daniel G; Owens, A Phillip; Martin, Janine K; Gourley, Benjamin; Rosenfeldt, Leah; Palumbo, Joseph S

TMPRSS6 as a Therapeutic Target for Disorders of Erythropoiesis and Iron Homeostasis

TMPRSS6 作为红细胞生成和铁稳态障碍的治疗靶点

Ganz, Tomas; Nemeth, Elizabeta; Rivella, Stefano; Goldberg, Paul; Dibble, Andrew R; McCaleb, Michael L; Guo, Shuling; Monia, Brett P; Barrett, Terrance D

In Vitro and In Vivo Effects of SerpinA1 on the Modulation of Transthyretin Proteolysis

SerpinA1对转甲状腺素蛋白水解的体外和体内调节作用

Bezerra, Filipa; Niemietz, Christoph; Schmidt, Hartmut H J; Zibert, Andree; Guo, Shuling; Monia, Brett P; Gonçalves, Paula; Saraiva, Maria João; Almeida, Maria Rosário

Design and Rationale of the Global Phase 3 NEURO-TTRansform Study of Antisense Oligonucleotide AKCEA-TTR-L(Rx) (ION-682884-CS3) in Hereditary Transthyretin-Mediated Amyloid Polyneuropathy

针对遗传性转甲状腺素蛋白介导的淀粉样多发性神经病,开展反义寡核苷酸AKCEA-TTR-L(Rx) (ION-682884-CS3)的全球3期NEURO-TTRansform研究的设计和原理

Coelho, Teresa; Ando, Yukio; Benson, Merrill D; Berk, John L; Waddington-Cruz, Márcia; Dyck, Peter J; Gillmore, Julian D; Khella, Sami L; Litchy, William J; Obici, Laura; Monteiro, Cecilia; Tai, Li-Jung; Viney, Nicholas J; Buchele, Gustavo; Brambatti, Michela; Jung, Shiangtung W; St L O'Dea, Louis; Tsimikas, Sotirios; Schneider, Eugene; Geary, Richard S; Monia, Brett P; Gertz, Morie

Ligand conjugated antisense oligonucleotide for the treatment of transthyretin amyloidosis: preclinical and phase 1 data

用于治疗转甲状腺素蛋白淀粉样变性的配体偶联反义寡核苷酸:临床前和 I 期数据

Viney, Nicholas J; Guo, Shuling; Tai, Li-Jung; Baker, Brenda F; Aghajan, Mariam; Jung, Shiangtung W; Yu, Rosie Z; Booten, Sheri; Murray, Heather; Machemer, Todd; Burel, Sebastien; Murray, Sue; Buchele, Gustavo; Tsimikas, Sotirios; Schneider, Eugene; Geary, Richard S; Benson, Merrill D; Monia, Brett P

Antisense oligonucleotide-mediated knockdown of Mpzl3 attenuates the negative metabolic effects of diet-induced obesity in mice

反义寡核苷酸介导的Mpzl3基因敲低可减轻饮食诱导肥胖对小鼠的负面代谢影响。

Worley, Beth L; Auen, Thomas; Arnold, Amy C; Monia, Brett P; Hempel, Nadine; Czyzyk, Traci A

Evaluation of the Antihemostatic and Antithrombotic Effects of Lowering Coagulation Factor VII Levels in a Non-human Primate

评估降低非人灵长类动物凝血因子VII水平的抗止血和抗血栓作用

Wallisch, Michael; Olson, Sven R; Crosby, Jeffrey; Johnson, Jennifer; Murray, Susan F; Shatzel, Joseph J; Tucker, Erik I; McCarty, Owen J T; Hinds, Monica T; Monia, Brett P; Gruber, András

Hepatic thrombopoietin gene silencing reduces platelet count and breast cancer progression in transgenic MMTV-PyMT mice

肝脏血小板生成素基因沉默可降低转基因MMTV-PyMT小鼠的血小板计数并延缓乳腺癌进展。

Shirai, Toshiaki; Revenko, Alexey S; Tibbitts, Justin; Ngo, Anh T P; Mitrugno, Annachiara; Healy, Laura D; Johnson, Jennifer; Tucker, Erik I; Hinds, Monica T; Coussens, Lisa M; McCarty, Owen J T; Monia, Brett P; Gruber, András

IONIS-PKK(Rx) a Novel Antisense Inhibitor of Prekallikrein and Bradykinin Production

IONIS-PKK(Rx) 是一种新型的激肽释放酶和缓激肽生成反义抑制剂

Ferrone, Jason D; Bhattacharjee, Gourab; Revenko, Alexey S; Zanardi, Thomas A; Warren, Marshelle S; Derosier, Frederick J; Viney, Nicholas J; Pham, Nguyen C; Kaeser, Gwendolyn E; Baker, Brenda F; Schneider, Eugene; Hughes, Steven G; Monia, Brett P; MacLeod, A Robert

Inotersen Treatment for Patients with Hereditary Transthyretin Amyloidosis

Inotersen治疗遗传性转甲状腺素蛋白淀粉样变性患者

Benson, Merrill D; Waddington-Cruz, Márcia; Berk, John L; Polydefkis, Michael; Dyck, Peter J; Wang, Annabel K; Planté-Bordeneuve, Violaine; Barroso, Fabio A; Merlini, Giampaolo; Obici, Laura; Scheinberg, Morton; Brannagan, Thomas H 3rd; Litchy, William J; Whelan, Carol; Drachman, Brian M; Adams, David; Heitner, Stephen B; Conceição, Isabel; Schmidt, Hartmut H; Vita, Giuseppe; Campistol, Josep M; Gamez, Josep; Gorevic, Peter D; Gane, Edward; Shah, Amil M; Solomon, Scott D; Monia, Brett P; Hughes, Steven G; Kwoh, T Jesse; McEvoy, Bradley W; Jung, Shiangtung W; Baker, Brenda F; Ackermann, Elizabeth J; Gertz, Morie A; Coelho, Teresa