Loss-of-function mutations in ISCA2 disrupt 4Fe-4S cluster machinery and cause a fatal leukodystrophy with hyperglycinemia and mtDNA depletion

ISCA2 的功能丧失突变会破坏 4Fe-4S 簇机制，并导致致命的白质营养不良，伴有高甘氨酸血症和线粒体 DNA 耗竭