Combined in silico/in vitro approaches for identifying modulators of the activity of the p.Tyr110Cys Carnitine O-Acetyltransferase (CRAT) variant associated to an early onset case of Leigh syndrome.
结合计算机模拟/体外方法,鉴定与早发性莱氏综合征相关的 p.Tyr110Cys 肉碱 O-乙酰转移酶 (CRAT) 变体的活性调节剂
期刊:Acta Pharmacologica Sinica
影响因子:8.4
doi:10.1038/s41401-024-01435-0
Cafferati Beltrame Lucas, Sgobba Maria Noemi, Laera Luna, Scaglione Valeria, Todisco Sabino, Barile Serena, Francavilla Anna Lucia, De Luca Danila Imperia, Montaruli Michele, Porcelli Vito, Guerra Lorenzo, De Grassi Anna, Volpicella Mariateresa, Pierri Ciro Leonardo