日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

EML4-ALK Variant-Specific Genetic Interactions Shape Lung Tumorigenesis

EML4-ALK 变异特异性基因相互作用影响肺肿瘤发生

Alberto Diaz-Jimenez #,Emily G Shuldiner #,Kalman Somogyi,Karen Y Shih,Óscar González-Velasco,Mulham Najajreh,Stewart Kim,Filiz Akkas,Christopher W Murray,Laura Andrejka,Min K Tsai,Benedikt Brors,Ilse Hofmann,Smruthy Sivakumar,Saumya D Sisoudiya,Ethan S Sokol,Hongchen Cai,Dmitri A Petrov,Monte M Winslow,Rocio Sotillo

Author Correction: CTLA4 blockade abrogates KEAP1/STK11-related resistance to PD-(L)1 inhibitors

作者更正:CTLA4阻断可消除KEAP1/STK11相关的PD-(L)1抑制剂耐药性

Skoulidis, Ferdinandos; Araujo, Haniel A; Do, Minh Truong; Qian, Yu; Sun, Xin; Cobo, Ana Galan; Le, John T; Montesion, Meagan; Palmer, Rachael; Jahchan, Nadine; Juan, Joseph M; Min, Chengyin; Yu, Yi; Pan, Xuewen; Arbour, Kathryn C; Vokes, Natalie; Schmidt, Stephanie T; Molkentine, David; Owen, Dwight H; Memmott, Regan; Patil, Pradnya D; Marmarelis, Melina E; Awad, Mark M; Murray, Joseph C; Hellyer, Jessica A; Gainor, Justin F; Dimou, Anastasios; Bestvina, Christine M; Shu, Catherine A; Riess, Jonathan W; Blakely, Collin M; Pecot, Chad V; Mezquita, Laura; Tabbó, Fabrizio; Scheffler, Matthias; Digumarthy, Subba; Mooradian, Meghan J; Sacher, Adrian G; Lau, Sally C M; Saltos, Andreas N; Rotow, Julia; Johnson, Rocio Perez; Liu, Corinne; Stewart, Tyler; Goldberg, Sarah B; Killam, Jonathan; Walther, Zenta; Schalper, Kurt; Davies, Kurtis D; Woodcock, Mark G; Anagnostou, Valsamo; Marrone, Kristen A; Forde, Patrick M; Ricciuti, Biagio; Venkatraman, Deepti; Van Allen, Eliezer M; Cummings, Amy L; Goldman, Jonathan W; Shaish, Hiram; Kier, Melanie; Katz, Sharyn; Aggarwal, Charu; Ni, Ying; Azok, Joseph T; Segal, Jeremy; Ritterhouse, Lauren; Neal, Joel W; Lacroix, Ludovic; Elamin, Yasir Y; Negrao, Marcelo V; Le, Xiuning; Lam, Vincent K; Lewis, Whitney E; Kemp, Haley N; Carter, Brett; Roth, Jack A; Swisher, Stephen; Lee, Richard; Zhou, Teng; Poteete, Alissa; Kong, Yifan; Takehara, Tomohiro; Paula, Alvaro Guimaraes; Parra Cuentas, Edwin R; Behrens, Carmen; Wistuba, Ignacio I; Zhang, Jianjun; Blumenschein, George R; Gay, Carl; Byers, Lauren A; Gibbons, Don L; Tsao, Anne; Lee, J Jack; Bivona, Trever G; Camidge, D Ross; Gray, Jhannelle E; Leighl, Natasha B; Levy, Benjamin; Brahmer, Julie R; Garassino, Marina C; Gandara, David R; Garon, Edward B; Rizvi, Naiyer A; Scagliotti, Giorgio Vittorio; Wolf, Jürgen; Planchard, David; Besse, Benjamin; Herbst, Roy S; Wakelee, Heather A; Pennell, Nathan A; Shaw, Alice T; Jänne, Pasi A; Carbone, David P; Hellmann, Matthew D; Rudin, Charles M; Albacker, Lee; Mann, Helen; Zhu, Zhou; Lai, Zhongwu; Stewart, Ross; Peters, Solange; Johnson, Melissa L; Wong, Kwok K; Huang, Alan; Winslow, Monte M; Rosen, Michael J; Winters, Ian P; Papadimitrakopoulou, Vassiliki A; Cascone, Tina; Jewsbury, Philip; Heymach, John V

Functional Mapping of Epigenomic Regulators Uncovers Coordinated Tumor Suppression by the HBO1 and MLL1 Complexes.

表观基因组调控因子的功能定位揭示了 HBO1 和 MLL1 复合物协同抑制肿瘤的作用。

Tang Yuning J, Xu Haiqing, Hughes Nicholas W, Ruiz Paloma, Kim Samuel H, Shuldiner Emily G, Lopez Steven S, Hebert Jess D, Karmakar Saswati, Andrejka Laura, Dolcen Deniz Nesli, Boross Gabor, Chu Pauline, Kunder Christian A, Detrick Colin, Pierce Sarah E, Ashkin Emily L, Greenleaf William J, Voss Anne K, Thomas Tim, van de Rijn Matt, Petrov Dmitri A, Winslow Monte M

Efficient and multiplexed somatic genome editing with Cas12a mice

利用Cas12a小鼠进行高效多重体细胞基因组编辑

Jess D Hebert # ,Haiqing Xu # ,Yuning J Tang ,Paloma A Ruiz ,Colin R Detrick ,Jing Wang ,Nicholas W Hughes ,Oscar Donosa ,Vicky P Siah ,Laura Andrejka ,Saswati Karmakar ,Irenosen Aboiralor ,Rui Tang ,Rocio Sotillo ,Julien Sage ,Le Cong ,Dmitri A Petrov ,Monte M Winslow

Aging represses oncogenic KRAS-driven lung tumorigenesis and alters tumor suppression.

衰老会抑制致癌基因 KRAS 驱动的肺部肿瘤发生,并改变肿瘤抑制机制。

Shuldiner Emily G, Karmakar Saswati, Tsai Min K, Hebert Jess D, Tang Yuning J, Andrejka Laura, Robertson Maggie R, Wang Minwei, Detrick Colin R, Cai Hongchen, Tang Rui, Kunder Christian A, Feldser David M, Petrov Dmitri A, Winslow Monte M

The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models

肺癌自体模型基因表达数据库能够对不同小鼠模型的转录组图谱进行跨研究比较

Cai, Ling; Wu, Fangjiang; Zhou, Qinbo; Gao, Ying; Yao, Bo; DeBerardinis, Ralph J; Acquaah-Mensah, George K; Aidinis, Vassilis; Beane, Jennifer E; Biswal, Shyam; Chen, Ting; Concepcion-Crisol, Carla P; Grüner, Barbara M; Jia, Deshui; Jones, Robert A; Kurie, Jonathan M; Lee, Min Gyu; Lindahl, Per; Lissanu, Yonathan; Lorz, Corina; MacPherson, David; Martinelli, Rosanna; Mazur, Pawel K; Mazzilli, Sarah A; Mii, Shinji; Moll, Herwig P; Moorehead, Roger A; Morrisey, Edward E; Ng, Sheng Rong; Oser, Matthew G; Pandiri, Arun R; Powell, Charles A; Ramadori, Giorgio; Santos, Mirentxu; Snyder, Eric L; Sotillo, Rocio; Su, Kang-Yi; Taki, Tetsuro; Taparra, Kekoa; Tran, Phuoc T; Xia, Yifeng; van Veen, J Edward; Winslow, Monte M; Xiao, Guanghua; Rudin, Charles M; Oliver, Trudy G; Xie, Yang; Minna, John D

Integrative multiomic approaches reveal ZMAT3 and p21 as conserved hubs in the p53 tumor suppression network

整合多组学方法揭示 ZMAT3 和 p21 是 p53 肿瘤抑制网络中的保守枢纽。

Boutelle, Anthony M; Mabene, Aicha R; Yao, David; Xu, Haiqing; Wang, Mengxiong; Tang, Yuning J; Lopez, Steven S; Sinha, Sauradeep; Demeter, Janos; Cheng, Ran; Benard, Brooks A; McCrea, Edel M; Valente, Liz J; Drainas, Alexandros P; Fischer, Martin; Majeti, Ravindra; Petrov, Dmitri A; Jackson, Peter K; Yang, Fan; Winslow, Monte M; Bassik, Michael C; Attardi, Laura D

RIT1 Drives Oncogenic Transformation and Is an Actionable Target in Lung Adenocarcinoma

RIT1驱动癌基因转化,是肺腺癌的可靶向治疗靶点

Alessandro M Mozzarelli,Antonio Cuevas-Navarro,Emily G Shuldiner,Martha Vega,Walid K Chatila,Jierui Xu,Henry S Walch,Yuzhe Niu,Dmitri A Petrov,Nikolaus Schultz,Anatoly Urisman,Charles M Rudin,Monte M Winslow,Pau Castel

A STAG2-PAXIP1/PAGR1 axis suppresses lung tumorigenesis.

STAG2-PAXIP1/PAGR1轴抑制肺部肿瘤发生

Ashkin Emily L, Tang Yuning J, Xu Haiqing, Hung King L, Belk Julia A, Cai Hongchen, Lopez Steven S, Dolcen Deniz Nesli, Hebert Jess D, Li Rui, Ruiz Paloma A, Keal Tula, Andrejka Laura, Chang Howard Y, Petrov Dmitri A, Dixon Jesse R, Xu Zhichao, Winslow Monte M

Combinatorial In Vivo Genome Editing Identifies Widespread Epistasis and an Accessible Fitness Landscape During Lung Tumorigenesis.

体内组合基因组编辑揭示了肺肿瘤发生过程中普遍存在的上位性以及可及的适应度景观

Hebert Jess D, Tang Yuning J, Szamecz Márton, Andrejka Laura, Lopez Steven S, Petrov Dmitri A, Boross Gábor, Winslow Monte M