Tofacitinib inhibits inflammatory cytokines from ulcerative colitis and healthy mucosal explants and is associated with pSTAT1/3 reduction in T-cells
托法替尼可抑制溃疡性结肠炎和健康黏膜外植体中的炎症细胞因子,并与T细胞中pSTAT1/3的减少有关。
期刊:American Journal of Physiology-Gastrointestinal and Liver Physiology
影响因子:3.3
doi:10.1152/ajpgi.00383.2020
Brand, Rhonda M; Moore, Beverley A; Zyhowski, Ashley; Siegel, Aaron; Uttam, Shikhar; Metter, E Jeffrey; Engstrom, Jarret; Brand, Randall E; Biswas, Nabanita; Whitcomb, David C; Binion, David G; Schwartz, Marc; McGowan, Ian
STAT1
肠炎
T细胞
炎症
炎症/感染
JAK/STAT
T细胞
细胞生物学
结肠炎
免疫/内分泌