日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Parkinson's disease-linked D620N mutation selectively alters the brain-specific protein interactome of VPS35

帕金森病相关的D620N突变选择性地改变了VPS35的脑特异性蛋白相互作用组

Williams, Erin T; Chen, Xi; Rowlands, Jordan; Islam, Md Shariful; Frye, Maxwell; Moore, Darren J

LRRK2 regulates ArfGAP1 membrane localization, activity and neuronal toxicity via phosphorylation within its lipid-sensing ALPS2 motif.

LRRK2 通过在其脂质感应 ALPS2 基序内进行磷酸化来调节 ArfGAP1 的膜定位、活性和神经毒性。

Shariful Islam Md, Cóppola-Segovia Valentin, Musso Alessandra, Moore Darren J

Pathological α-synuclein elicits granulovacuolar degeneration independent of tau.

病理性α-突触核蛋白可引起与tau蛋白无关的颗粒空泡变性

Dues Dylan J, Erb Madalynn L, Kasen Alysa, Vatsa Naman, Williams Erin T, Nguyen An Phu Tran, Henderson Michael X, Moore Darren J

Twelve Years of Drug Prioritization to Help Accelerate Disease Modification Trials in Parkinson's Disease: The International Linked Clinical Trials Initiative

十二年来药物优先排序助力加速帕金森病疾病修饰试验:国际联合临床试验计划

Wyse, Richard K; Isaacs, Tom; Barker, Roger A; Cookson, Mark R; Dawson, Ted M; Devos, David; Dexter, David T; Duffen, Joy; Federoff, Howard; Fiske, Brian; Foltynie, Thomas; Fox, Susan; Greenamyre, J Timothy; Kieburtz, Karl; Kordower, Jeffrey H; Krainc, Dimitri; Matthews, Helen; Moore, Darren J; Mursaleen, Leah; Schwarzschild, Michael A; Stott, Simon R W; Sulzer, David; Svenningsson, Per; Tanner, Caroline M; Carroll, Camille; Simon, David K; Brundin, Patrik

VPS35 and retromer dysfunction in Parkinson's disease

帕金森病中的VPS35和逆转录酶功能障碍

Rowlands, Jordan; Moore, Darren J

Hippocampal subfield vulnerability to α-synuclein pathology precedes neurodegeneration and cognitive dysfunction

海马亚区对α-突触核蛋白病理的易感性先于神经退行性变和认知功能障碍。

Dues, Dylan J; Nguyen, An Phu Tran; Becker, Katelyn; Ma, Jiyan; Moore, Darren J

Understanding the contributions of VPS35 and the retromer in neurodegenerative disease

了解VPS35和逆转录酶在神经退行性疾病中的作用

Williams, Erin T; Chen, Xi; Otero, P Anthony; Moore, Darren J

Multiple genetic pathways regulating lifespan extension are neuroprotective in a G2019S LRRK2 nematode model of Parkinson's disease

在帕金森病G2019S LRRK2线虫模型中,多个调控寿命延长的基因通路具有神经保护作用。

Senchuk, Megan M; Van Raamsdonk, Jeremy M; Moore, Darren J

Mechanisms of VPS35-Mediated Neurodegeneration in Parkinson's Disease

帕金森病中VPS35介导的神经退行性变机制

Sargent, Dorian; Moore, Darren J

LRRK2 and Protein Aggregation in Parkinson's Disease: Insights From Animal Models

LRRK2与帕金森病中的蛋白质聚集:来自动物模型的启示

Dues, Dylan J; Moore, Darren J