日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PIKfyve inhibition in MM disrupts autophagy and lysosome function, increasing MHC expression and cholesterol metabolism.

PIKfyve 在 MM 中受到抑制会破坏自噬和溶酶体功能,增加 MHC 表达和胆固醇代谢。

Bonolo de Campos Cecilia, He Ruijuan, Pelino Tessa, Abelman Dor D, Li Zhihua, Lee Daniel K C, Wang Ding Yan, St Paul Michael, Bruce Jeffrey, Simpson Craig D, Wybeng-Groot Leanne, Moran Michael F, Tiedemann Rodger, Pugh Trevor, Mak Tak W, Issakova Olga, Sepetov Nikolai, Trudel Suzanne, Stewart A Keith

Modeling response to the KRAS-G12C inhibitor AZD4625 in KRAS(G12C) NSCLC patient-derived xenografts reveals insights into primary resistance mechanisms

在KRAS(G12C)非小细胞肺癌患者来源的异种移植模型中模拟KRAS-G12C抑制剂AZD4625的反应,揭示了原发性耐药机制的奥秘。

Rosen, Joshua C; Cao, Pinjiang; Pham, Nhu-An; Waas, Matthew; Li, Quan; Hueniken, Katrina; Wang, Mutian; Navab, Roya; Wybenga-Groot, Leanne; Radulovich, Nikolina; Niedbala, Michael; Koers, Alex; Ross, Sarah; Moran, Michael F; Sacher, Adrian; Tsao, Ming-Sound

Targeting synthetic lethality between non-homologous end joining and radiation in very-high-risk medulloblastoma.

针对极高危髓母细胞瘤中非同源末端连接与放射治疗之间的合成致死性进行靶向治疗

DeCarlo Alexandria, MacLeod Graham, Fernandes da Silva Carolina, Shen Li Qing, Povilaikaite Julija, Deane Madeline, Aragao Lucas, Sie Mariska, Termini Deborah, Magee Jonathan, Gudenas Brian, Sukumaran Sneha, Charron Frederic, Marcellus Richard, Al-Awar Rima, Aman Ahmed, Reynaud Denis, Trolat Amarine, Wybenga-Groot Leanne, Tabori Uri, Nör Carolina, Harding Shane M, Moran Michael F, Northcott Paul A, Dirks Peter, Angers Stephane, Ramaswamy Vijay

Activation of mitogen-activated protein kinase signaling and development of papillary thyroid carcinoma in thyroid-stimulating hormone receptor D633H knockin mice

促甲状腺激素受体D633H敲入小鼠中丝裂原活化蛋白激酶信号通路的激活和乳头状甲状腺癌的发生

Eszlinger, Markus; Stephenson, Alexandra; Mirhadi, Shideh; Patyra, Konrad; Moran, Michael F; Khalil, Moosa; Kero, Jukka; Paschke, Ralf

Reinspection of a Clinical Proteomics Tumor Analysis Consortium (CPTAC) Dataset with Cloud Computing Reveals Abundant Post-Translational Modifications and Protein Sequence Variants

利用云计算对临床蛋白质组学肿瘤分析联盟(CPTAC)数据集进行重新分析,揭示了大量的翻译后修饰和蛋白质序列变异

Prakash, Amol; Taylor, Lorne; Varkey, Manu; Hoxie, Nate; Mohammed, Yassene; Goo, Young Ah; Peterman, Scott; Moghekar, Abhay; Yuan, Yuting; Glaros, Trevor; Steele, Joel R; Faridi, Pouya; Parihari, Shashwati; Srivastava, Sanjeeva; Otto, Joseph J; Nyalwidhe, Julius O; Semmes, O John; Moran, Michael F; Madugundu, Anil; Mun, Dong Gi; Pandey, Akhilesh; Mahoney, Keira E; Shabanowitz, Jeffrey; Saxena, Satya; Orsburn, Benjamin C

The Candida albicans transcription factor Cas5 couples stress responses, drug resistance and cell cycle regulation.

白色念珠菌转录因子 Cas5 将应激反应、耐药性和细胞周期调控联系起来

Xie Jinglin L, Qin Longguang, Miao Zhengqiang, Grys Ben T, Diaz Jacinto De La Cruz, Ting Kenneth, Krieger Jonathan R, Tong Jiefei, Tan Kaeling, Leach Michelle D, Ketela Troy, Moran Michael F, Krysan Damian J, Boone Charles, Andrews Brenda J, Selmecki Anna, Ho Wong Koon, Robbins Nicole, Cowen Leah E

A strategy for modulation of enzymes in the ubiquitin system

泛素系统中酶的调控策略

Ernst, Andreas; Avvakumov, George; Tong, Jiefei; Fan, Yihui; Zhao, Yanling; Alberts, Philipp; Persaud, Avinash; Walker, John R; Neculai, Ana-Mirela; Neculai, Dante; Vorobyov, Andrew; Garg, Pankaj; Beatty, Linda; Chan, Pak-Kei; Juang, Yu-Chi; Landry, Marie-Claude; Yeh, Christina; Zeqiraj, Elton; Karamboulas, Konstantina; Allali-Hassani, Abdellah; Vedadi, Masoud; Tyers, Mike; Moffat, Jason; Sicheri, Frank; Pelletier, Laurence; Durocher, Daniel; Raught, Brian; Rotin, Daniela; Yang, Jianhua; Moran, Michael F; Dhe-Paganon, Sirano; Sidhu, Sachdev S

Identification and selected reaction monitoring (SRM) quantification of endocytosis factors associated with Numb

鉴定和选择性反应监测 (SRM) 定量与 Numb 相关的内吞因子

Krieger, Jonathan R; Taylor, Paul; Gajadhar, Aaron S; Guha, Abhijit; Moran, Michael F; McGlade, C Jane

Proteomic profiling of the planarian Schmidtea mediterranea and its mucous reveals similarities with human secretions and those predicted for parasitic flatworms

对地中海涡虫及其粘液的蛋白质组学分析表明,其与人类分泌物以及寄生扁形动物的预测分泌物具有相似性。

Bocchinfuso, Donald G; Taylor, Paul; Ross, Eric; Ignatchenko, Alex; Ignatchenko, Vladimir; Kislinger, Thomas; Pearson, Bret J; Moran, Michael F

Selected Reaction Monitoring (SRM) Analysis of Epidermal Growth Factor Receptor (EGFR) in Formalin Fixed Tumor Tissue

利用选择性反应监测(SRM)技术分析福尔马林固定肿瘤组织中的表皮生长因子受体(EGFR)

Hembrough, Todd; Thyparambil, Sheeno; Liao, Wei-Li; Darfler, Marlene M; Abdo, Joseph; Bengali, Kathleen M; Taylor, Paul; Tong, Jiefei; Lara-Guerra, Humberto; Waddell, Thomas K; Moran, Michael F; Tsao, Ming-Sound; Krizman, David B; Burrows, Jon