Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism.
Adaptaquin 通过破坏铁和胆固醇代谢,对神经胶质瘤干细胞具有选择性毒性。
期刊:Molecular Oncology
影响因子:4.5
doi:10.1002/1878-0261.70128
Vaquié Adrien M, Shah Davod R, Brechbühl Eliane E S, McNicholas Michael, Xu Zhaoyang, Stockley John H, Morcom Laura, Gold Diaz Diana, Girdler Gemma C, Seear Rachel V, Balmus Gabriel, Ratan Rajiv R, Bulstrode Harry, Nathan James A, Pathania Manav, Brindle Kevin M, Rowitch David H
发育与干细胞
细胞生物学
神经科学
代谢
干细胞
胶质瘤
毒理研究