日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

TBK1 orchestrates autophagy and endo-lysosomal pathways in human neurons

TBK1调控人类神经元中的自噬和内吞溶酶体途径

Mordes, Daniel A; Smeyers, Julie

Polymorphisms in intron 1 of HLA-DRA differentially associate with type 1 diabetes and celiac disease and implicate involvement of complement system genes C4A and C4B

HLA-DRA基因内含子1的多态性与1型糖尿病和乳糜泻存在差异性关联,并提示补体系统基因C4A和C4B参与其中。

Aydemir, Ozkan; Bailey, Jeffrey A; Agardh, Daniel; Lernmark, Åke; Noble, Janelle A; Andersson Svärd, Agnes; Blankenhorn, Elizabeth P; Parikh, Hemang M; Ziegler, Anette-G; Toppari, Jorma; Akolkar, Beena; Hagopian, William A; Rewers, Marian J; Mordes, John P

High-throughput discovery of fluoroprobes that recognize amyloid fibril polymorphs.

利用高通量方法发现可识别淀粉样蛋白原纤维多晶型的荧光探针。

Carroll Emma C, Yang Hyunjun, Powell Wyatt C, Charvat Annemarie F, Oehler Abby, Jones Julia G, Montgomery Kelly M, Yung Anthony, Millbern Zoe, Taylor Alexander I P, Wilkinson Martin, Ranson Neil A, Radford Sheena E, Vinueza Nelson R, DeGrado William F, Mordes Daniel A, Condello Carlo, Gestwicki Jason E

Phospho-proteome profiling in human neurons reveals targets of TBK1 in ALS/FTD-associated autophagy networks.

人类神经元磷酸化蛋白质组分析揭示了 TBK1 在 ALS/FTD 相关自噬网络中的靶点。

Smeyers Julie, Oses-Prieto Juan A, Yadanar Lin, Wang Man, Iadarola Marci, Lu Serena, Wang Karen S, Watanabe Taylor H, Debnath Jayanta, Burlingame Alma L, Mordes Daniel A

C9ORF72 poly-PR disrupts expression of ALS/FTD-implicated STMN2 through SRSF7.

C9ORF72 poly-PR 通过 SRSF7 破坏 ALS/FTD 相关 STMN2 的表达

Wang Karen S, Smeyers Julie, Eggan Kevin, Budnik Bogdan, Mordes Daniel A

Cryo-EM structure of a novel α-synuclein filament subtype from multiple system atrophy

多系统萎缩症中一种新型α-突触核蛋白丝亚型的冷冻电镜结构

Yan, Nicholas L; Candido, Francisco; Tse, Eric; Melo, Arthur A; Prusiner, Stanley B; Mordes, Daniel A; Southworth, Daniel R; Paras, Nick A; Merz, Gregory E

Vitreous STMN2 levels reflect TDP-43-associated neurodegeneration in postmortem eyes and brains

玻璃体STMN2水平反映了死后眼球和脑组织中与TDP-43相关的神经退行性变。

Pulukuri, Surya V; Spurlock, Elizabeth E; Tuz-Zahra, Fatima; Tripodis, Yorghos; Sampani, Konstantina; Nicks, Raymond; Meng, Gaoyuan; Alvarez, Victor E; McKee, Ann C; Xia, Weiming; Mordes, Daniel A; Subramanian, Manju L; Stein, Thor D

TDP‐43 related mis‐splicing and decreased protein levels of synapse related genes are associated with cognitive impairment in chronic traumatic encephalopathy

TDP-43相关的错误剪接和突触相关基因蛋白水平降低与慢性创伤性脑病中的认知障碍有关。

Haditsch, Ursula; Leone, Dino P; Farinelli, Mélissa; Chrostek-Grashoff, Anna; Brakebusch, Cord; Mansuy, Isabelle M; McConnell, Susan K; Palmer, Theo D; Stein, Thor D; Aytan, Nurgul; Empawi, Jenny A; Nicks, Raymond; Cherry, Jonathan D; Alvarez, Victor E; Alosco, Michael L; Mez, Jesse; Labadorf, Adam Thomas; McKee, Ann C; Zhang, Xiaoling; Mordes, Daniel A

Single-nucleus sequencing reveals enriched expression of genetic risk factors in extratelencephalic neurons sensitive to degeneration in ALS

单核测序揭示了对 ALS 退化敏感的端脑神经元中遗传风险因子的丰富表达

Francesco Limone #, Daniel A Mordes #, Alexander Couto, Brian J Joseph, Jana M Mitchell, Martine Therrien, Sulagna Dia Ghosh, Daniel Meyer, Yingying Zhang, Melissa Goldman, Laura Bortolin, Inma Cobos, Beth Stevens, Steven A McCarroll, Irena Kadiu, Aaron Burberry, Olli Pietiläinen, Kevin Eggan

Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP

tau 单个残基的磷酸化会抑制其与 E3 泛素连接酶 CHIP 的结合

Cory M Nadel, Saugat Pokhrel, Kristin Wucherer, Abby Oehler, Aye C Thwin, Koli Basu, Matthew D Callahan, Daniel R Southworth, Daniel A Mordes, Charles S Craik, Jason E Gestwicki