日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Biallelic mutations in BRCA1 cause a new Fanconi anemia subtype

BRCA1基因的双等位基因突变导致一种新的范可尼贫血亚型

Sawyer, Sarah L; Tian, Lei; Kähkönen, Marketta; Schwartzentruber, Jeremy; Kircher, Martin; Majewski, Jacek; Dyment, David A; Innes, A Micheil; Boycott, Kym M; Moreau, Lisa A; Moilanen, Jukka S; Greenberg, Roger A

Inactivation of Uaf1 causes defective homologous recombination and early embryonic lethality in mice

Uaf1基因失活会导致小鼠同源重组缺陷和早期胚胎致死。

Park, Eunmi; Kim, Jung Min; Primack, Benjamin; Weinstock, David M; Moreau, Lisa A; Parmar, Kalindi; D'Andrea, Alan D

Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia

急性髓系白血病中MET受体酪氨酸激酶的自分泌激活

Kentsis, Alex; Reed, Casie; Rice, Kim L; Sanda, Takaomi; Rodig, Scott J; Tholouli, Eleni; Christie, Amanda; Valk, Peter J M; Delwel, Ruud; Ngo, Vu; Kutok, Jeffery L; Dahlberg, Suzanne E; Moreau, Lisa A; Byers, Richard J; Christensen, James G; Vande Woude, George; Licht, Jonathan D; Kung, Andrew L; Staudt, Louis M; Look, A Thomas

Inhibition of the Nedd8 system sensitizes cells to DNA interstrand cross-linking agents

抑制Nedd8系统会使细胞对DNA链间交联剂更加敏感

Kee, Younghoon; Huang, Min; Chang, Sophia; Moreau, Lisa A; Park, Eunmi; Smith, Peter G; D'Andrea, Alan D

Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition

CDK1活性受损会使具有BRCA功能的癌症对PARP抑制剂更加敏感

Johnson, Neil; Li, Yu-Chen; Walton, Zandra E; Cheng, Katherine A; Li, Danan; Rodig, Scott J; Moreau, Lisa A; Unitt, Christine; Bronson, Roderick T; Thomas, Huw D; Newell, David R; D'Andrea, Alan D; Curtin, Nicola J; Wong, Kwok-Kin; Shapiro, Geoffrey I

Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60.

组蛋白 H3 甲基化将 DNA 损伤检测与肿瘤抑制因子 Tip60 的激活联系起来

Sun Yingli, Jiang Xiaofeng, Xu Ye, Ayrapetov Marina K, Moreau Lisa A, Whetstine Johnathan R, Price Brendan D

Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression

Emi1在斑马鱼胚胎发生过程中维持基因组完整性,并与p53协同抑制肿瘤。

Rhodes, Jennifer; Amsterdam, Adam; Sanda, Takaomi; Moreau, Lisa A; McKenna, Keith; Heinrichs, Stefan; Ganem, Neil J; Ho, Karen W; Neuberg, Donna S; Johnston, Adam; Ahn, Yebin; Kutok, Jeffery L; Hromas, Robert; Wray, Justin; Lee, Charles; Murphy, Carly; Radtke, Ina; Downing, James R; Fleming, Mark D; MacConaill, Laura E; Amatruda, James F; Gutierrez, Alejandro; Galinsky, Ilene; Stone, Richard M; Ross, Eric A; Pellman, David S; Kanki, John P; Look, A Thomas

Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability

表观遗传肿瘤抑制因子SNF5的缺失会导致癌症,而无需基因组不稳定。

McKenna, Elizabeth S; Sansam, Courtney G; Cho, Yoon-Jae; Greulich, Heidi; Evans, Julia A; Thom, Christopher S; Moreau, Lisa A; Biegel, Jaclyn A; Pomeroy, Scott L; Roberts, Charles W M