日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Redox regulation of pyruvate kinase M2 by cysteine oxidation and S-nitrosation.

半胱氨酸氧化和S-亚硝化对丙酮酸激酶M2的氧化还原调控

Mitchell Alice Rose, Yuan Meng, Morgan Hugh P, McNae Iain W, Blackburn Elizabeth A, Le Bihan Thierry, Homem Rafael A, Yu Manda, Loake Gary J, Michels Paul A, Wear Martin A, Walkinshaw Malcolm D

Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase

鉴定出ML251,一种强效的布氏锥虫和克氏锥虫磷酸果糖激酶抑制剂

Brimacombe, Kyle R; Walsh, Martin J; Liu, Li; Vásquez-Valdivieso, Montserrat G; Morgan, Hugh P; McNae, Iain; Fothergill-Gilmore, Linda A; Michels, Paul A M; Auld, Douglas S; Simeonov, Anton; Walkinshaw, Malcolm D; Shen, Min; Boxer, Matthew B

A new family of covalent inhibitors block nucleotide binding to the active site of pyruvate kinase.

一类新型共价抑制剂可阻断核苷酸与丙酮酸激酶活性位点的结合

Morgan Hugh P, Walsh Martin J, Blackburn Elizabeth A, Wear Martin A, Boxer Matthew B, Shen Min, Veith Henrike, McNae Iain W, Nowicki Matthew W, Michels Paul A M, Auld Douglas S, Fothergill-Gilmore Linda A, Walkinshaw Malcolm D

Structural analysis of the C-terminal region (modules 18-20) of complement regulator factor H (FH)

补体调节因子H(FH)C端区域(模块18-20)的结构分析

Morgan, Hugh P; Mertens, Haydyn D T; Guariento, Mara; Schmidt, Christoph Q; Soares, Dinesh C; Svergun, Dmitri I; Herbert, Andrew P; Barlow, Paul N; Hannan, Jonathan P

Structural basis for engagement by complement factor H of C3b on a self surface

补体因子H与自身表面C3b结合的结构基础

Morgan, Hugh P; Schmidt, Christoph Q; Guariento, Mara; Blaum, Bärbel S; Gillespie, Dominic; Herbert, Andrew P; Kavanagh, David; Mertens, Haydyn D T; Svergun, Dmitri I; Johansson, Conny M; Uhrín, Dušan; Barlow, Paul N; Hannan, Jonathan P

The trypanocidal drug suramin and other trypan blue mimetics are inhibitors of pyruvate kinases and bind to the adenosine site.

锥虫杀灭药物苏拉明和其他锥虫蓝类似物是丙酮酸激酶抑制剂,可与腺苷结合

Morgan Hugh P, McNae Iain W, Nowicki Matthew W, Zhong Wenhe, Michels Paul A M, Auld Douglas S, Fothergill-Gilmore Linda A, Walkinshaw Malcolm D

Allosteric mechanism of pyruvate kinase from Leishmania mexicana uses a rock and lock model

墨西哥利什曼原虫丙酮酸激酶的变构机制采用摇锁模型

Morgan, Hugh P; McNae, Iain W; Nowicki, Matthew W; Hannaert, Véronique; Michels, Paul A M; Fothergill-Gilmore, Linda A; Walkinshaw, Malcolm D

An improved strategy for the crystallization of Leishmania mexicana pyruvate kinase

改进的墨西哥利什曼原虫丙酮酸激酶结晶策略

Morgan, Hugh P; McNae, Iain W; Hsin, Kun-Yi; Michels, Paul A M; Fothergill-Gilmore, Linda A; Walkinshaw, Malcolm D

Crystallization and X-ray structure of cold-shock protein E from Salmonella typhimurium

鼠伤寒沙门氏菌冷休克蛋白E的结晶和X射线结构

Morgan, Hugh P; Wear, Martin A; McNae, Iain; Gallagher, Maurice P; Walkinshaw, Malcolm D