日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A precision gene-engineered B cell medicine producing sustained levels of active factor IX for hemophilia B therapy

一种精准基因工程改造的B细胞药物,可产生持续水平的活性凝血因子IX,用于治疗B型血友病。

Liu, Hanlan; Singh, Swati; Mullen, Timothy J; Bullock, Caroline; Keegan, Sean; Patterson, Troy; Thakur, Sakshisingh; Lundberg, Amy; Shenker, Sol; Couto, Ryan; Yadav, Charuta; Dastagir, Shamael; Li, Lily; Bainter, Wayne; Liberzon, Ella; Malloy, Connor R; Lazzarotto, Cicera R; Ohsumi, Toshiro K; Chilakala, Shalini; Chen, Huei-Mei; Kshirsagar, Rashmi; Hohmann, Anja F; Arlauckas, Sean P; Lazorchak, Adam; Scull, Chris; Morgan, Richard A

In vivo tracking of ex-vivo-generated (89)Zr-oxine-labeled plasma cells by PET in a non-human primate model

利用PET在非人灵长类动物模型中对体外生成的(89)Zr-oxine标记的浆细胞进行体内追踪

Young, David J; Edwards, Abigail J; Quiroz Caceda, Kevin G; Liberzon, Ella; Barrientos, Johana; Hong, So Gun; Turner, Jacob; Choyke, Peter L; Arlauckas, Sean; Lazorchak, Adam S; Morgan, Richard A; Sato, Noriko; Dunbar, Cynthia E

Human plasma cells engineered to secrete bispecifics drive effective in vivo leukemia killing.

经基因工程改造可分泌双特异性抗体的人类浆细胞可有效杀灭体内白血病细胞

Hill Tyler F, Narvekar Parnal, Asher Gregory D, Edelstein Jasmine N, Camp Nathan D, Grimm Annaiz, Thomas Kerri R, Leiken Michael D, Molloy Katherine M, Cook Peter J, Arlauckas Sean P, Morgan Richard A, Tasian Sarah K, Rawlings David J, James Richard G

In vivo tracking of ex vivo generated (89) Zr-oxine labeled plasma cells by PET in a non-human primate model

在非人灵长类动物模型中,利用PET对体外生成的(89)锆-氧杂环己烯标记的浆细胞进行体内追踪

Young, David J; Edwards, Abigail J; Quiroz Caceda, Kevin G; Liberzon, Ella; Barrientos, Johana; Hong, Sogun; Turner, Jacob; Choyke, Peter L; Arlauckas, Sean; Lazorchak, Adam S; Morgan, Richard A; Sato, Noriko; Dunbar, Cynthia E

Lentiviral gene therapy for X-linked chronic granulomatous disease recapitulates endogenous CYBB regulation and expression

用于治疗X连锁慢性肉芽肿病的慢病毒基因疗法能够重现内源性CYBB的调控和表达。

Wong, Ryan L; Sackey, Sarah; Brown, Devin; Senadheera, Shantha; Masiuk, Katelyn; Quintos, Jason P; Colindres, Nicole; Riggan, Luke; Morgan, Richard A; Malech, Harry L; Hollis, Roger P; Kohn, Donald B

Improved Titer and Gene Transfer by Lentiviral Vectors Using Novel, Small β-Globin Locus Control Region Elements

利用新型小型β-珠蛋白基因座控制区元件提高慢病毒载体的滴度和基因转移效率

Morgan, Richard A; Unti, Mildred J; Aleshe, Bamidele; Brown, Devin; Osborne, Kyle S; Koziol, Colin; Ayoub, Paul G; Smith, Oliver B; O'Brien, Rachel; Tam, Curtis; Miyahira, Eric; Ruiz, Marlene; Quintos, Jason P; Senadheera, Shantha; Hollis, Roger P; Kohn, Donald B

Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma

抗BCMA CAR T细胞疗法bb2121治疗复发或难治性多发性骨髓瘤

Raje, Noopur; Berdeja, Jesus; Lin, Yi; Siegel, David; Jagannath, Sundar; Madduri, Deepu; Liedtke, Michaela; Rosenblatt, Jacalyn; Maus, Marcela V; Turka, Ashley; Lam, Lyh-Ping; Morgan, Richard A; Friedman, Kevin; Massaro, Monica; Wang, Julie; Russotti, Greg; Yang, Zhihong; Campbell, Timothy; Hege, Kristen; Petrocca, Fabio; Quigley, M Travis; Munshi, Nikhil; Kochenderfer, James N

Sensitive and adaptable pharmacological control of CAR T cells through extracellular receptor dimerization

通过细胞外受体二聚化对CAR T细胞进行灵敏且可适应的药理学控制

Leung, Wai-Hang; Gay, Joel; Martin, Unja; Garrett, Tracy E; Horton, Holly M; Certo, Michael T; Blazar, Bruce R; Morgan, Richard A; Gregory, Philip D; Jarjour, Jordan; Astrakhan, Alexander

Pilot Trial of Adoptive Transfer of Chimeric Antigen Receptor-transduced T Cells Targeting EGFRvIII in Patients With Glioblastoma

嵌合抗原受体转导的T细胞过继转移治疗胶质母细胞瘤患者的试点试验

Goff, Stephanie L; Morgan, Richard A; Yang, James C; Sherry, Richard M; Robbins, Paul F; Restifo, Nicholas P; Feldman, Steven A; Lu, Yong-Chen; Lu, Lily; Zheng, Zhili; Xi, Liqiang; Epstein, Monica; McIntyre, Lori S; Malekzadeh, Parisa; Raffeld, Mark; Fine, Howard A; Rosenberg, Steven A

Effective Targeting of Multiple B-Cell Maturation Antigen-Expressing Hematological Malignances by Anti-B-Cell Maturation Antigen Chimeric Antigen Receptor T Cells.

利用抗B细胞成熟抗原嵌合抗原受体T细胞有效靶向多种表达B细胞成熟抗原的血液恶性肿瘤

Friedman Kevin M, Garrett Tracy E, Evans John W, Horton Holly M, Latimer Howard J, Seidel Stacie L, Horvath Christopher J, Morgan Richard A