日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function

线粒体ABHD11抑制驱动甾醇代谢,从而调节T细胞效应功能

Benjamin J Jenkins # ,Yasmin R Jenkins # ,Fernando M Ponce-Garcia ,Chloe Moscrop ,Iain A Perry ,Matthew D Hitchings ,Alejandro H Uribe ,Federico Bernuzzi ,Simon Eastham ,James G Cronin ,Ardena Berisha ,Alexandra Howell ,Joanne Davies ,Julianna Blagih ,Marta Williams ,Morgan Marsden ,Douglas J Veale ,Luke C Davies ,Micah Niphakis ,David K Finlay ,Linda V Sinclair ,Benjamin F Cravatt ,Andrew E Hogan ,James A Nathan ,Ian R Humphreys ,Ursula Fearon ,David Sumpton ,Johan Vande Voorde ,Goncalo Dias do Vale ,Jeffrey G McDonald ,Gareth W Jones ,James A Pearson ,Emma E Vincent ,Nicholas Jones

Cytomegalovirus-induced peroxynitrite promotes virus entry and contributes to pathogenesis in a murine model of infection

巨细胞病毒诱导的过氧亚硝酸盐促进病毒入侵,并在小鼠感染模型中促进发病机制。

Pragati S Amratia ,Lauren E Kerr-Jones ,Lucy Chapman ,Morgan Marsden ,Mathew Clement ,Richard J Stanton ,Ian R Humphreys

Inhibitory IL-10-producing CD4+ T cells are T-bet-dependent and facilitate cytomegalovirus persistence via coexpression of arginase-1

抑制性IL-10产生型CD4+ T细胞依赖于T-bet,并通过精氨酸酶-1的共表达促进巨细胞病毒的持续感染。

Mathew Clement ,Kristin Ladell ,Kelly L Miners ,Morgan Marsden ,Lucy Chapman ,Anna Cardus Figueras ,Jake Scott ,Robert Andrews ,Simon Clare ,Valeriia V Kriukova ,Ksenia R Lupyr ,Olga V Britanova ,David R Withers ,Simon A Jones ,Dmitriy M Chudakov ,David A Price ,Ian R Humphreys

Optimal CD8+ T-cell memory formation following subcutaneous cytomegalovirus infection requires virus replication but not early dendritic cell responses

皮下巨细胞病毒感染后最佳 CD8+ T 细胞记忆形成需要病毒复制,但不需要早期树突状细胞反应

Sandra Dimonte, Silvia Gimeno-Brias, Morgan Marsden, Lucy Chapman, Pragati Sabberwal, Mathew Clement, Ian R Humphreys

IRF5 Promotes Influenza Virus-Induced Inflammatory Responses in Human Induced Pluripotent Stem Cell-Derived Myeloid Cells and Murine Models

IRF5 促进人类诱导性多能干细胞衍生的髓系细胞和小鼠模型中流感病毒诱发的炎症反应

Jessica L Forbester, Mathew Clement, Dannielle Wellington, Amy Yeung, Sandra Dimonte, Morgan Marsden, Lucy Chapman, Eve L Coomber, Charlotte Tolley, Emily Lees, Christine Hale, Simon Clare, Irina Udalova, Tao Dong, Gordon Dougan, Ian R Humphreys

IL-33 Augments Virus-Specific Memory T Cell Inflation and Potentiates the Efficacy of an Attenuated Cytomegalovirus-Based Vaccine

IL-33 增强病毒特异性记忆 T 细胞增殖并提高减毒巨细胞病毒疫苗的疗效

James E McLaren ,Mathew Clement ,Morgan Marsden ,Kelly L Miners ,Sian Llewellyn-Lacey ,Emma J Grant ,Anzelika Rubina ,Silvia Gimeno Brias ,Emma Gostick ,Maria A Stacey ,Selinda J Orr ,Richard J Stanton ,Kristin Ladell ,David A Price ,Ian R Humphreys

Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity

组蛋白伴侣 HIRA 将组蛋白 H3.3 沉积到外来病毒 DNA 上,并有助于抗病毒内在免疫

Taranjit Singh Rai, Mandy Glass, John J Cole, Mohammad I Rather, Morgan Marsden, Matthew Neilson, Claire Brock, Ian R Humphreys, Roger D Everett, Peter D Adams

The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis

抗病毒限制因子 IFN 诱导的跨膜蛋白 3 可阻止细胞因子驱动的 CMV 发病机制

Maria A Stacey, Simon Clare, Mathew Clement, Morgan Marsden, Juneid Abdul-Karim, Leanne Kane, Katherine Harcourt, Cordelia Brandt, Ceri A Fielding, Sarah E Smith, Rachael S Wash, Silvia Gimeno Brias, Gabrielle Stack, George Notley, Emma L Cambridge, Christopher Isherwood, Anneliese O Speak, Zoë John

Cytomegalovirus-Specific IL-10-Producing CD4+ T Cells Are Governed by Type-I IFN-Induced IL-27 and Promote Virus Persistence

巨细胞病毒特异性 IL-10 产生 CD4+ T 细胞受 I 型 IFN 诱导的 IL-27 调控并促进病毒持久性

Mathew Clement, Morgan Marsden, Maria A Stacey, Juneid Abdul-Karim, Silvia Gimeno Brias, Diana Costa Bento, Martin J Scurr, Peter Ghazal, Casey T Weaver, Gianluca Carlesso, Simon Clare, Simon A Jones, Andrew Godkin, Gareth W Jones, Ian R Humphreys

CD200 receptor restriction of myeloid cell responses antagonizes antiviral immunity and facilitates cytomegalovirus persistence within mucosal tissue

CD200 受体限制髓系细胞反应,拮抗抗病毒免疫,促进巨细胞病毒在粘膜组织内持续存在

Gabrielle Stack, Emma Jones, Morgan Marsden, Maria A Stacey, Robert J Snelgrove, Paul Lacaze, Laura C Jacques, Simone M Cuff, Richard J Stanton, Awen M Gallimore, Tracy Hussell, Gavin W G Wilkinson, Peter Ghazal, Philip R Taylor, Ian R Humphreys