日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

ABBV-319: a CD19-targeting glucocorticoid receptor modulator antibody-drug conjugate therapy for B-cell malignancies

ABBV-319：一种靶向CD19的糖皮质激素受体调节剂抗体药物偶联疗法，用于治疗B细胞恶性肿瘤

期刊:Blood
影响因子:21
doi:10.1182/blood.2024023849
Chewei Anderson Chang ，Ethan Emberley ，Aloma L D'Souza ，Weilong Zhao ，Cormac Cosgrove ，Karen Parrish ，Diya Mitra ，Elmer Payson ，Anatol Oleksijew ，Paul Ellis ，Luis Rodriguez ，Ryan Duggan ，Cara Hrusch ，Loren Lasko ，Wissam Assaily ，Pingping Zheng ，Wei Liu ，Axel Hernandez Jr ，Kimberley McCarthy ，Zhaomei Zhang ，Geunbae Rha ，Zhensheng Cao ，Yingchun Li ，Olivia Perng ，Jos Campbell ，Gloria Zhang ，Tyler Curran ，Milan Bruncko ，Christopher C Marvin ，Adrian Hobson ，Michael McPherson ，Tamar Uziel ，Marybeth A Pysz ，Xi Zhao ，Alex Bankovich ，Joel Hayflick ，Michael McDevitt ，Kevin J Freise ，Susan Morgan-Lappe ，James W Purcell
免疫/内分泌
信号转导
肿瘤免疫
细胞生物学
CD19
肿瘤
B细胞
发表日期：2024
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Activity of eftozanermin alfa plus venetoclax in preclinical models and patients with acute myeloid leukemia

eftozanermin alfa 联合 venetoclax 在急性髓系白血病临床前模型和患者中的活性

期刊:Blood
影响因子:23.1
doi:10.1182/blood.2022017333
Tahir, Stephen K; Calvo, Emiliano; Carneiro, Benedito A; Yuda, Junichiro; Shreenivas, Aditya; Jongen-Lavrencic, Mojca; Gort, Eelke; Ishizawa, Kenichi; Morillo, Daniel; Biesdorf, Carla; Smith, Morey; Cheng, Dong; Motwani, Monica; Sharon, David; Uziel, Tamar; Modi, Dimple A; Buchanan, Fritz G; Morgan-Lappe, Susan; Medeiros, Bruno C; Phillips, Darren C
白血病
发表日期：2023
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Eftozanermin alfa (ABBV-621) monotherapy in patients with previously treated solid tumors: findings of a phase 1, first-in-human study

Eftozanermin alfa (ABBV-621) 单药治疗既往接受过治疗的实体瘤患者：一项 1 期首次人体试验的结果

期刊:Investigational New Drugs
影响因子:2.7
doi:10.1007/s10637-022-01247-1
LoRusso, Patricia; Ratain, Mark J; Doi, Toshihiko; Rasco, Drew W; de Jonge, Maja J A; Moreno, Victor; Carneiro, Benedito A; Devriese, Lot A; Petrich, Adam; Modi, Dimple; Morgan-Lappe, Susan; Nuthalapati, Silpa; Motwani, Monica; Dunbar, Martin; Glasgow, Jaimee; Medeiros, Bruno C; Calvo, Emiliano
发表日期：2022
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Hexavalent TRAIL Fusion Protein Eftozanermin Alfa Optimally Clusters Apoptosis-Inducing TRAIL Receptors to Induce On-Target Antitumor Activity in Solid Tumors

六价 TRAIL 融合蛋白 Eftozanermin Alfa 最佳聚集诱导凋亡的 TRAIL 受体以诱导实体肿瘤中的靶向抗肿瘤活性

期刊:Cancer Research
影响因子:12.5
doi:10.1158/0008-5472.CAN-20-2178
Darren C Phillips #, Fritz G Buchanan #, Dong Cheng, Larry R Solomon, Yu Xiao, John Xue, Stephen K Tahir, Morey L Smith, Haichao Zhang, Deborah Widomski, Vivek C Abraham, Nan Xu, Zhihong Liu, Li Zhou, Enrico DiGiammarino, Xin Lu, Nandini Rudra-Ganguly, Bruce Trela, Susan E Morgan-Lappe
信号转导
肿瘤
Apoptosis
发表日期：2021
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Phase I Open-Label Study Evaluating the Safety, Pharmacokinetics, and Preliminary Efficacy of Dilpacimab in Patients with Advanced Solid Tumors

评估 Dilpacimab 对晚期实体瘤患者的安全性、药代动力学和初步疗效的 I 期开放标签研究

期刊:Molecular Cancer Therapeutics
影响因子:5.3
doi:10.1158/1535-7163.MCT-20-0985
Michael S Gordon, John Nemunaitis, Minal Barve, Zev A Wainberg, Erika P Hamilton, Ramesh K Ramanathan, George W Sledge Jr, Huibin Yue, Susan E Morgan-Lappe, Martha Blaney, Sreeneeranj Kasichayanula, Monica Motwani, Lan Wang, Louie Naumovski, John H Strickler
肿瘤
发表日期：2021
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ABT-165, a Dual Variable Domain Immunoglobulin (DVD-Ig) Targeting DLL4 and VEGF, Demonstrates Superior Efficacy and Favorable Safety Profiles in Preclinical Models

ABT-165 是一种靶向 DLL4 和 VEGF 的双可变域免疫球蛋白 (DVD-Ig)，在临床前模型中表现出卓越的疗效和良好的安全性

期刊:Molecular Cancer Therapeutics
影响因子:5.3
doi:10.1158/1535-7163.MCT-17-0800
Yingchun Li #, Jonathan A Hickson #, Dominic J Ambrosi, Deanna L Haasch, Kelly D Foster-Duke, Lucia J Eaton, Enrico L DiGiammarino, Sanjay C Panchal, Fang Jiang, Sarah R Mudd, Catherine Zhang, Surekha S Akella, Wenqing Gao, Sherry L Ralston, Louie Naumovski, Jijie Gu, Susan E Morgan-Lappe
免疫
发表日期：2018
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Kinome siRNA-phosphoproteomic screen identifies networks regulating AKT signaling

激酶组 siRNA-磷酸化蛋白质组筛选鉴定出调控 AKT 信号通路的网络

期刊:Oncogene
影响因子:7.3
doi:10.1038/onc.2011.164
Lu, Y; Muller, M; Smith, D; Dutta, B; Komurov, K; Iadevaia, S; Ruths, D; Tseng, J T; Yu, S; Yu, Q; Nakhleh, L; Balazsi, G; Donnelly, J; Schurdak, M; Morgan-Lappe, S; Fesik, S; Ram, P T; Mills, G B
信号转导
磷酸化
AKT
发表日期：2011
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