日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Amylovis-201 is a new dual-target ligand, acting as an anti-amyloidogenic compound and a potent agonist of the σ (1) chaperone protein

Amylovis-201 是一种新型双靶点配体,既具有抗淀粉样蛋白生成作用,又是 σ(1) 分子伴侣蛋白的强效激动剂。

García-Pupo, Laura; Crouzier, Lucie; Bencomo-Martínez, Alberto; Meunier, Johann; Morilleau, Axelle; Delprat, Benjamin; Carrazana, Marquiza Sablón; Menéndez Soto Del Valle, Roberto; Maurice, Tangui; Rodríguez-Tanty, Chryslaine

Dual-Acting Small Molecules: Subtype-Selective Cannabinoid Receptor 2 Agonist/Butyrylcholinesterase Inhibitor Hybrids Show Neuroprotection in an Alzheimer's Disease Mouse Model

双重作用的小分子:亚型选择性大麻素受体 2 激动剂/丁酰胆碱酯酶抑制剂混合物在阿尔茨海默病小鼠模型中表现出神经保护作用

Philipp Spatz, Sophie A M Steinmüller, Anna Tutov, Eleonora Poeta, Axelle Morilleau, Allison Carles, Marie H Deventer, Julian Hofmann, Christophe P Stove, Barbara Monti, Tangui Maurice, Michael Decker