日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Bioisosteric Replacement of Amides with 1,2,3-Triazoles Improves Dopamine D4 Receptor Ligand Pharmacokinetics

用1,2,3-三唑类化合物生物等排取代酰胺类化合物可改善多巴胺D4受体配体的药代动力学

期刊:ACS Pharmacology and Translational Science
影响因子:3.7
doi:10.1021/acsptsci.5c00646
Alkhatib, Mohammad; Jakobs, Franziska M; Hanson, John N; Nilson, Ashley N; Moritz, Amy E; Li, Tian; Faibille, Afua B; Bourn, Lindsay A; Ramdhan, Peter A; Ricchezza, Joseph 4th; Jordan, Shannon; Panasis, Diandra; Nguyen, Norman; Kasarla, Nitish; Wang, Bryant; Garcia, Sergio Sola; Saez, Julianna; Paule, James; Lee, Chae Bin; Rais, Rana; Slusher, Barbara S; Sibley, David R; Li, Chenglong; Keck, Thomas M; Boateng, Comfort A
信号转导
发表日期：2026
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Dissociable control of motivation and reinforcement by distinct ventral striatal dopamine receptors.

腹侧纹状体多巴胺受体对动机和强化进行可分离控制

期刊:Nature Neuroscience
影响因子:20
doi:10.1038/s41593-024-01819-9
Enriquez-Traba Juan, Arenivar Miguel, Yarur-Castillo Hector E, Noh Chloe, Flores Rodolfo J, Weil Tenley, Roy Snehashis, Usdin Ted B, LaGamma Christina T, Wang Huikun, Tsai Valerie S, Kerspern Damien, Moritz Amy E, Sibley David R, Lutas Andrew, Moratalla Rosario, Freyberg Zachary, Tejeda Hugo A
信号转导
发表日期：2025
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Kappa opioid receptor antagonism restores phosphorylation, trafficking and behavior induced by a disease-associated dopamine transporter variant

κ阿片受体拮抗剂可恢复由疾病相关的多巴胺转运体变体诱导的磷酸化、转运和行为。

期刊:Molecular Psychiatry
影响因子:10.1
doi:10.1038/s41380-025-03055-4
Mayer, Felix P; Stewart, Adele; Varman, Durairaj Ragu; Moritz, Amy E; Foster, James D; Owens, Anthony W; Areal, Lorena B; Gowrishankar, Raajaram; Velez, Michelle; Wickham, Kyria; Phelps, Hannah; Katamish, Rania; Rabil, Maximilian; Jayanthi, Lankupalle D; Vaughan, Roxanne A; Daws, Lynette C; Blakely, Randy D; Ramamoorthy, Sammanda
信号转导
磷酸化
发表日期：2025
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Discovery, Characterization, and Optimization of a Novel Positive Allosteric Modulator-Antagonist of the D(3) Dopamine Receptor.

发现、表征和优化一种新型的D(3)多巴胺受体正向变构调节剂-拮抗剂

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c01585
Moritz Amy E, Wang Feijun, Madaras Nora S, Kelley Amber M, Snyder Kirsten K, Gandhi Disha, Inbody Laura R, Akano Emmanuel O, Shi Lei, Lane J Robert, Free R Benjamin, Frankowski Kevin J, Sibley David R
其它
发表日期：2025
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Multiple Allosteric Sites Allow for Synergistic Enhancement of GPCR Signaling

多个变构位点可协同增强GPCR信号传导

期刊:
影响因子:
doi:10.1101/2025.10.21.683604
Wang, Kai; Dimova, Snezana T; Hanson, John N; Thakur, Abhishek; Xu, Youwei; Liu, Yini; Moritz, Amy E; Goldberg, Alexander; Xie, Bing; Rayadurgam, Jayachandra; Wang, Feijun; Nilson, Ashley N; Luderman, Kathryn D; Free, R Benjamin; Hu, Wen; Zhang, Jian; Xu, H Eric; Frankowski, Kevin J; Wang, Yue; Shi, Lei; Sibley, David R; Zhuang, Youwen
信号转导
GPCR/Calcium/cAMP
发表日期：2025
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Dopamine receptor divergence revealed using a common ligand

利用共同配体揭示多巴胺受体的差异

期刊:Trends in Pharmacological Sciences
影响因子:19.9
doi:10.1016/j.tips.2023.08.002
Sibley, David R; Nilson, Ashley N; Moritz, Amy E; Shi, Lei
信号转导
发表日期：2023
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Dissociable control of motivation and reinforcement by distinct ventral striatal dopamine receptors

腹侧纹状体多巴胺受体对动机和强化进行可分离的控制

期刊:
影响因子:
doi:10.1101/2023.06.27.546539
Enriquez-Traba, Juan; Yarur-Castillo, Hector E; Flores, Rodolfo J; Weil, Tenley; Roy, Snehashis; Usdin, Ted B; LaGamma, Christina T; Arenivar, Miguel; Wang, Huikun; Tsai, Valerie S; Moritz, Amy E; Sibley, David R; Moratalla, Rosario; Freyberg, Zachary Z; Tejeda, Hugo A
信号转导
发表日期：2023
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A structural basis for how ligand binding site changes can allosterically regulate GPCR signaling and engender functional selectivity

配体结合位点变化如何通过变构调节GPCR信号传导并产生功能选择性的结构基础

期刊:Science Signaling
影响因子:6.6
doi:10.1126/scisignal.aaw5885
Sanchez-Soto, Marta; Verma, Ravi Kumar; Willette, Blair K A; Gonye, Elizabeth C; Moore, Annah M; Moritz, Amy E; Boateng, Comfort A; Yano, Hideaki; Free, R Benjamin; Shi, Lei; Sibley, David R
信号转导
GPCR/Calcium/cAMP
发表日期：2020
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Advances and challenges in the search for D(2) and D(3) dopamine receptor-selective compounds

D(2)和D(3)多巴胺受体选择性化合物的研究进展与挑战

期刊:Cellular Signalling
影响因子:3.7
doi:10.1016/j.cellsig.2017.07.003
Moritz, Amy E; Free, R Benjamin; Sibley, David R
信号转导
发表日期：2018
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Identification of Positive Allosteric Modulators of the D(1) Dopamine Receptor That Act at Diverse Binding Sites

鉴定作用于不同结合位点的D(1)多巴胺受体正向变构调节剂

期刊:Molecular Pharmacology
影响因子:3
doi:10.1124/mol.118.113175
Luderman, Kathryn D; Conroy, Jennie L; Free, R Benjamin; Southall, Noel; Ferrer, Marc; Sanchez-Soto, Marta; Moritz, Amy E; Willette, Blair K A; Fyfe, Tim J; Jain, Prashi; Titus, Steve; Hazelwood, Lisa A; Aubé, Jeffrey; Lane, J Robert; Frankowski, Kevin J; Sibley, David R
信号转导
发表日期：2018
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