日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF

靶向DCAF5可通过稳定SWI/SNF抑制SMARCB1突变型癌症。

Sandi Radko-Juettner # ,Hong Yue # ,Jacquelyn A Myers ,Raymond D Carter ,Alexis N Robertson ,Priya Mittal ,Zhexin Zhu ,Baranda S Hansen ,Katherine A Donovan ,Moritz Hunkeler ,Wojciech Rosikiewicz ,Zhiping Wu ,Meghan G McReynolds ,Shourya S Roy Burman ,Anna M Schmoker ,Nada Mageed ,Scott A Brown ,Robert J Mobley ,Janet F Partridge ,Elizabeth A Stewart ,Shondra M Pruett-Miller ,Behnam Nabet ,Junmin Peng ,Nathanael S Gray ,Eric S Fischer ,Charles W M Roberts

Continuous evolution of compact protein degradation tags regulated by selective molecular glues

选择性分子胶调控紧密蛋白质降解标签的持续进化

Jaron A M Mercer #, Stephan J DeCarlo #, Shourya S Roy Burman #, Vedagopuram Sreekanth, Andrew T Nelson, Moritz Hunkeler, Peter J Chen, Katherine A Donovan, Praveen Kokkonda, Praveen K Tiwari, Veronika M Shoba, Arghya Deb, Amit Choudhary, Eric S Fischer, David R Liu

Polymerization of ZBTB transcription factors regulates chromatin occupancy

ZBTB转录因子的聚合调控染色质占据

Paul M C Park,Jiho Park,Jared Brown,Moritz Hunkeler,Shourya S Roy Burman,Katherine A Donovan,Hojong Yoon,Radosław P Nowak,Mikołaj Słabicki,Benjamin L Ebert,Eric S Fischer

Template-assisted covalent modification underlies activity of covalent molecular glues

模板辅助共价修饰是共价分子胶活性的基础

Yen-Der Li #, Michelle W Ma #, Muhammad Murtaza Hassan #, Moritz Hunkeler, Mingxing Teng, Kedar Puvar, Justine C Rutter, Ryan J Lumpkin, Brittany Sandoval, Cyrus Y Jin, Anna M Schmoker, Scott B Ficarro, Hakyung Cheong, Rebecca J Metivier, Michelle Y Wang, Shawn Xu, Woong Sub Byun, Brian J Groendyke,

Structural basis of regulated m7G tRNA modification by METTL1-WDR4

METTL1-WDR4 调控 m7G tRNA 修饰的结构基础

Jiazhi Li #, Longfei Wang #, Quentin Hahn, Radosław P Nowak, Thibault Viennet, Esteban A Orellana, Shourya S Roy Burman, Hong Yue, Moritz Hunkeler, Pietro Fontana, Hao Wu, Haribabu Arthanari, Eric S Fischer, Richard I Gregory

Structures of BIRC6-client complexes provide a mechanism of SMAC-mediated release of caspases

BIRC6-客户端复合物的结构提供了 SMAC 介导的 caspase 释放机制

Moritz Hunkeler, Cyrus Y Jin, Eric S Fischer

HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways

HAPSTR1 将 HUWE1 定位到细胞核中以限制应激信号通路

Julie K Monda, Xuezhen Ge, Moritz Hunkeler, Katherine A Donovan, Michelle W Ma, Cyrus Y Jin, Marilyn Leonard, Eric S Fischer, Eric J Bennett

Template-assisted covalent modification of DCAF16 underlies activity of BRD4 molecular glue degraders

模板辅助共价修饰 DCAF16 是 BRD4 分子胶降解剂活性的基础

Yen-Der Li, Michelle W Ma, Muhammad Murtaza Hassan, Moritz Hunkeler, Mingxing Teng, Kedar Puvar, Ryan Lumpkin, Brittany Sandoval, Cyrus Y Jin, Scott B Ficarro, Michelle Y Wang, Shawn Xu, Brian J Groendyke, Logan H Sigua, Isidoro Tavares, Charles Zou, Jonathan M Tsai, Paul M C Park, Hojong Yoon, Feli

Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition

HUWE1 的螺线管结构有助于连接酶活性和底物识别

Moritz Hunkeler, Cyrus Y Jin, Michelle W Ma, Julie K Monda, Daan Overwijn, Eric J Bennett, Eric S Fischer

Small-molecule-induced polymerization triggers degradation of BCL6

小分子诱导聚合引发BCL6降解

Mikołaj Słabicki # ,Hojong Yoon # ,Jonas Koeppel # ,Lena Nitsch ,Shourya S Roy Burman ,Cristina Di Genua ,Katherine A Donovan ,Adam S Sperling ,Moritz Hunkeler ,Jonathan M Tsai ,Rohan Sharma ,Andrew Guirguis ,Charles Zou ,Priya Chudasama ,Jessica A Gasser ,Peter G Miller ,Claudia Scholl ,Stefan Fröhling ,Radosław P Nowak ,Eric S Fischer ,Benjamin L Ebert