日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

BH3 profiling as pharmacodynamic biomarker for the activity of BH3 mimetics

BH3谱分析作为BH3模拟物活性的药效学生物标志物

Pan, Rongqing Aaron; Wang, Youzhen; Qiu, Shumei; Villalobos-Ortiz, Mariana; Ryan, Jeremy; Morris, Erick; Halilovic, Ensar; Letai, Anthony

Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia.

BAX 基因的获得性突变可使急性髓系白血病对 BH3 模拟疗法产生耐药性

Moujalled Donia M, Brown Fiona C, Chua Chong Chyn, Dengler Michael A, Pomilio Giovanna, Anstee Natasha S, Litalien Veronique, Thompson Ella, Morley Thomas, MacRaild Sarah, Tiong Ing S, Morris Rhiannon, Dun Karen, Zordan Adrian, Shah Jaynish, Banquet Sebastien, Halilovic Ensar, Morris Erick, Herold Marco J, Lessene Guillaume, Adams Jerry M, Huang David C S, Roberts Andrew W, Blombery Piers, Wei Andrew H

Phase I Study of Taminadenant (PBF509/NIR178), an Adenosine 2A Receptor Antagonist, with or without Spartalizumab (PDR001), in Patients with Advanced Non-Small Cell Lung Cancer

一项针对晚期非小细胞肺癌患者的I期研究,评估腺苷2A受体拮抗剂Taminadenant(PBF509/NIR178)联合或不联合Spartalizumab(PDR001)的疗效。

Chiappori, Alberto A; Creelan, Ben; Tanvetyanon, Tawee; Gray, Jhanelle E; Haura, Eric B; Thapa, Ram; Barlow, Margaret L; Chen, Zhihua; Chen, Dung Tsa; Beg, Amer A; Boyle, Theresa A; Castro, Julio; Morgan, Liza; Morris, Erick; Aregay, Mehreteab; Hurtado, Felipe K; Manenti, Luigi; Antonia, Scott

The Drosophila homolog of human tumor suppressor TSC-22 promotes cellular growth, proliferation, and survival

果蝇中与人类肿瘤抑制因子TSC-22同源的基因能够促进细胞生长、增殖和存活。

Wu, Xiaodong; Yamada-Mabuchi, Megumu; Morris, Erick J; Tanwar, Pradeep Singh; Dobens, Leonard; Gluderer, Silvia; Khan, Sabina; Cao, Jing; Stocker, Hugo; Hafen, Ernst; Dyson, Nick J; Raftery, Laurel A

E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage

E2F 和 p53 在果蝇发育过程中独立诱导细胞凋亡,但在 DNA 损伤的情况下二者作用相互交织。

Moon, Nam-Sung; Di Stefano, Luisa; Morris, Erick J; Patel, Reena; White, Kristin; Dyson, Nicholas J

Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo.

在体内,Api5 被证实是一种 E2F 依赖性细胞凋亡的抑制因子

Morris Erick J, Michaud William A, Ji Jun-Yuan, Moon Nam-Sung, Rocco James W, Dyson Nicholas J