日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Tolvaptan safety in autosomal-dominant polycystic kidney disease; a focus on idiosyncratic drug-induced liver injury liabilities

托伐普坦在常染色体显性多囊肾病中的安全性;重点关注特异性药物性肝损伤风险

Hammond, Sean; Meng, Xiaoli; Barber, Jane; Mosedale, Merrie; Chadwick, Amy; Watkins, Paul B; Naisbitt, Dean J

Human-relevant mechanisms and risk factors for TAK-875-Induced liver injury identified via a gene pathway-based approach in Collaborative Cross mice

通过基于基因通路的方法,在协作交叉小鼠中鉴定出与人类相关的TAK-875诱导肝损伤机制和风险因素

Mosedale, Merrie; Cai, Yanwei; Eaddy, J Scott; Kirby, Patrick J; Wolenski, Francis S; Dragan, Yvonne; Valdar, William

Pregnancy-Related Hormones Increase Nifedipine Metabolism in Human Hepatocytes by Inducing CYP3A4 Expression

妊娠相关激素通过诱导CYP3A4表达增加人肝细胞中硝苯地平的代谢

Khatri, Raju; Kulick, Natasha; Rementer, Rebecca J B; Fallon, John K; Sykes, Craig; Schauer, Amanda P; Malinen, Melina M; Mosedale, Merrie; Watkins, Paul B; Kashuba, Angela D M; Boggess, Kim A; Smith, Philip C; Brouwer, Kim L R; Lee, Craig R

Differential Detergent Fractionation of Membrane Protein From Small Samples of Hepatocytes and Liver Tissue for Quantitative Proteomic Analysis of Drug Metabolizing Enzymes and Transporters

利用差异去垢剂分级分离法从少量肝细胞和肝组织样本中分离膜蛋白,用于药物代谢酶和转运蛋白的定量蛋白质组学分析

Qasem, Rani J; Fallon, John K; Nautiyal, Manisha; Mosedale, Merrie; Smith, Philip C

Characterization of primary mouse hepatocyte spheroids as a model system to support investigations of drug-induced liver injury

以原代小鼠肝细胞球体为模型系统,研究药物性肝损伤

Nautiyal, Manisha; Qasem, Rani J; Fallon, John K; Wolf, Kristina K; Liu, Jingli; Dixon, Darlene; Smith, Philip C; Mosedale, Merrie

Tolvaptan- and Tolvaptan-Metabolite-Responsive T Cells in Patients with Drug-Induced Liver Injury

药物性肝损伤患者体内对托伐普坦及其代谢物有反应的T细胞

Gibson, Andrew; Hammond, Sean; Jaruthamsophon, Kanoot; Roth, Sharin; Mosedale, Merrie; Naisbitt, Dean J

Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury

体外机制试验的定量系统毒理学分析揭示了胆汁酸积累和线粒体功能障碍在TAK-875诱导的肝损伤中的重要性

Longo, Diane M; Woodhead, Jeffrey L; Walker, Paul; Herédi-Szabó, Krisztina; Mogyorósi, Károly; Wolenski, Francis S; Dragan, Yvonne P; Mosedale, Merrie; Siler, Scott Q; Watkins, Paul B; Howell, Brett A

Identification of Candidate Risk Factor Genes for Human Idelalisib Toxicity Using a Collaborative Cross Approach

利用协作交叉方法鉴定人类伊德拉利西布毒性的候选风险因素基因

Mosedale, Merrie; Cai, Yanwei; Eaddy, John Scott; Corty, Robert W; Nautiyal, Manisha; Watkins, Paul B; Valdar, William

Bioprinted liver provides early insight into the role of Kupffer cells in TGF-β1 and methotrexate-induced fibrogenesis

生物打印肝脏为早期了解库普弗细胞在TGF-β1和甲氨蝶呤诱导的纤维化中的作用提供了线索

Norona, Leah M; Nguyen, Deborah G; Gerber, David A; Presnell, Sharon C; Mosedale, Merrie; Watkins, Paul B

miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model.

在原代人肝细胞微图案共培养模型中,外泌体中 miR-122 的释放先于托伐普坦诱导的明显坏死

Mosedale Merrie, Eaddy J Scott, Trask O Joseph Jr, Holman Natalie S, Wolf Kristina K, LeCluyse Edward, Ware Brenton R, Khetani Salman R, Lu Jingtao, Brock William J, Roth Sharin E, Watkins Paul B