Panels of chemically-modified heparin polysaccharides and natural heparan sulfate saccharides both exhibit differences in binding to Slit and Robo, as well as variation between protein binding and cellular activity
经化学修饰的肝素多糖和天然硫酸乙酰肝素糖类化合物在与Slit和Robo的结合方面均存在差异,且蛋白质结合与细胞活性之间也存在差异。
期刊:Molecular Biosystems
影响因子:
doi:10.1039/c6mb00432f
Ahmed, Yassir A; Yates, Edwin A; Moss, Diana J; Loeven, Markus A; Hussain, Sadaf-Ahmahni; Hohenester, Erhard; Turnbull, Jeremy E; Powell, Andrew K