日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Heterozygous NFKB1 variant causes inflammatory dysregulation shaped by broader genetic context in common variable immunodeficiency

杂合子 NFKB1 变异导致炎症失调,这种失调受常见变异型免疫缺陷更广泛的遗传背景影响。

Hayes, Kevin M; Boldt, Kai; Schnorr, Peter J; Bawa, Pushpinder; Abyazi, Miranda L; Ware, Matthew S; Gyimesi, Gavin; James, Marianne; Ko, Huaibin M; Cunningham-Rundles, Charlotte; Mizgerd, Joseph P; Mostoslavsky, Gustavo; Kotton, Darrell N; Maglione, Paul J

Oxidation of retromer complex controls mitochondrial translation

逆转录酶复合物的氧化控制线粒体翻译

Zhang, Junbing; Ali, Md Yousuf; Chong, Harrison Byron; Tien, Pei-Chieh; Woods, James; Noble, Carolina; Vornbäumen, Tristan; Ordulu, Zehra; Possemato, Anthony P; Harry, Stefan; Fonticella, Jay Miguel; Fellah, Lina; Harrison, Drew; Ge, Maolin; Khandelwal, Neha; Huang, Yingfei; Chauvin, Maëva; Bischof, Anica Tamara; Hambelton, Grace Marie; Gohar, Magdy Farag; Zhang, Siwen; Choi, MinGyu; Bouberhan, Sara; Oliva, Esther; Mino-Kenudson, Mari; Pavlova, Natalya N; Lawrence, Michael; Gainor, Justin F; Beausoleil, Sean A; Bardeesy, Nabeel; Mostoslavsky, Raul; Pépin, David; Ott, Christopher J; Liau, Brian; Bar-Peled, Liron

ZNF280A links DNA double-strand break repair to human 22q11.2 distal deletion syndrome

ZNF280A 将 DNA 双链断裂修复与人类 22q11.2 远端缺失综合征联系起来

Clarke, Thomas L; Cho, Hyo Min; Ceppi, Ilaria; Gao, Boya; Yadav, Tribhuwan; Silveira, Giorgia G; Boon, Ruben; Martinez-Pastor, Barbara; Amoh, Nana Yaa A; Machin, Belen; Bernasocchi, Tiziano; Ashfaq, Dua; Mendez, Josefina; Kamaliyan, Zeeba; Del Río Pantoja, José; Rogines, Giuliana Sardi; Crowley, Blaine T; McGinn, Daniel E; Giunta, Victoria; Tran, Oanh; Zackai, Elaine H; Lan, Li; Zou, Lee; Emanuel, Beverly S; McDonald-McGinn, Donna M; Cejka, Petr; Mostoslavsky, Raul

Expression of intron-containing HIV-1 RNA induces NLRP1 inflammasome activation in myeloid cells

含内含子的HIV-1 RNA的表达可诱导髓系细胞中NLRP1炎症小体的激活。

Sallieu Jalloh ,Ivy K Hughes ,Hisashi Akiyama ,Aldana D Gojanovich ,Andres A Quiñones-Molina ,Mengwei Yang ,Andrew J Henderson ,Gustavo Mostoslavsky ,Suryaram Gummuluru

Human-induced Pluripotent Stem Cell-derived Gut Organoids Recapitulate Regional Specific Genetic Programs and a Role for cAMP in Lineage Specification

人诱导多能干细胞来源的肠道类器官重现了区域特异性遗传程序,并揭示了 cAMP 在谱系分化中的作用。

Flores, Elizabeth Y; Mithal, Aditya; Bawa, Pushpinder; Wang, Feiya; D'Amico, Andrew; O'Connell, Aoife K; Gertje, Hans P; Tseng, Anna E; Crossland, Nicholas A; Alekseyev, Yuriy; Mostoslavsky, Gustavo

Mu opioid receptor activation in microglia enhances HIV-1 infection and HIV-infection-induced inflammatory responses

小胶质细胞中μ阿片受体的激活会增强HIV-1感染和HIV感染诱导的炎症反应。

Chelsey Skeete ,Gabriel Sgambettera ,Aldana D Gojanovich ,Xianbao He ,Daniel Bryant ,Mengwei Yang ,Shreya Banerjee ,Andrés A Quiñones-Molina ,Hisashi Akiyama ,Gustavo Mostoslavsky ,Andrew J Henderson ,Suryaram Gummuluru

Filovirus infection disrupts epithelial barrier function and ion transport in human iPSC-derived gut organoids

丝状病毒感染会破坏人诱导多能干细胞衍生的肠道类器官的上皮屏障功能和离子转运。

Flores, Elizabeth Y; Hume, Adam J; Olejnik, Judith; Mithal, Aditya; D'Amico, Andrew; Yang, MengWei; Bawa, Pushpinder; Wang, Feiya; O'Connell, Aoife K; Tseng, Anna; Crossland, Nicholas A; Mostoslavsky, Gustavo; Mühlberger, Elke

SIRT2 attenuates stress-induced skeletal muscle atrophy by inhibiting glucocorticoid receptor signalling

SIRT2通过抑制糖皮质激素受体信号传导来减轻应激引起的骨骼肌萎缩

Tamta, Ankit Kumar; Shivanaiah, Bhoomika; Prabhashankar, Arathi Bangalore; Ningaraju, Sunayana; Subhadarshini, Seemadri; Sharma, Anurag Nagaraja; Jayaprakasan, Harsha Mambully; E R, Meera Krishnan; Bhuyar, Apeksha; Sunil, Devika; Shrama, Amarjeet; Nagesh, Dimple; Munjal, Aastha; Raghu, Sukanya; Madhuri, Manepalli Bhavya; Rajesh, Dhevi; Ramasubbu, Venketsubbu; Sarikhani, Mohsen; Tandon, Himani; Desingu, Perumal Arumugam; Diwakar, Latha; Nath, Utpal; Nair, Deepak; Singh, Amit; Sowdhamini, Ramanathan; Srinivasan, Narayanaswamy; Mostoslavsky, Raul; Asirvatham-Jeyaraj, Ninitha; Sundaresan, Nagalingam Ravi

Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity

突变型IDH1抑制诱导dsDNA识别,从而激活肿瘤免疫

Meng-Ju Wu # ,Hiroshi Kondo # ,Ashwin V Kammula # ,Lei Shi ,Yi Xiao ,Sofiene Dhiab ,Qin Xu ,Chloe J Slater ,Omar I Avila ,Joshua Merritt ,Hiroyuki Kato ,Prabhat Kattel ,Jonathan Sussman ,Ilaria Gritti ,Jason Eccleston ,Yi Sun ,Hyo Min Cho ,Kira Olander ,Takeshi Katsuda ,Diana D Shi ,Milan R Savani ,Bailey C Smith ,James M Cleary, Raul Mostoslavsky ,Vindhya Vijay ,Yosuke Kitagawa ,Hiroaki Wakimoto ,Russell W Jenkins ,Kathleen B Yates ,Jihye Paik ,Ania Tassinari ,Duygu Hatice Saatcioglu ,Adriana E Tron ,Wilhelm Haas ,Daniel Cahill ,Samuel K McBrayer ,Robert T Manguso ,Nabeel Bardeesy

Abnormal synaptic architecture in iPSC-derived neurons from a multi-generational family with genetic Creutzfeldt-Jakob disease

来自患有遗传性克雅氏病的多代家族的iPSC衍生神经元中突触结构异常

Gojanovich, Aldana D; Le, Nhat T T; Mercer, Robert C C; Park, Seonmi; Wu, Bei; Anane, Alice; Vultaggio, Janelle S; Mostoslavsky, Gustavo; Harris, David A