SADS-CoV nsp1 inhibits the STAT1 phosphorylation by promoting K11/K48-linked polyubiquitination of JAK1 and blocks the STAT1 acetylation by degrading CBP
SADS-CoV nsp1 通过促进 JAK1 的 K11/K48 连接的多聚泛素化来抑制 STAT1 磷酸化,并通过降解 CBP 来阻断 STAT1 乙酰化。
期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2024.105779
Xiang, Yingjie; Mou, Chunxiao; Zhu, Liqi; Wang, Ziyan; Shi, Kaichuang; Bao, Wenbin; Li, Jiarui; Chen, Xiang; Chen, Zhenhai
JAK1
表观遗传
STAT1
JAK/STAT
信号转导
泛素化
CBP
乙酰化
磷酸化