Mouchlis相关文献与解析，生知库 | 链接生命科学的每一步

The mechanism of allosteric regulation of calcium-independent phospholipase A(2) by ATP and calmodulin binding to the ankyrin domain

ATP和钙调蛋白与锚蛋白结构域结合，对钙非依赖性磷脂酶A2进行变构调节的机制

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.2411539121

Mouchlis, Varnavas D; Hsu, Yuan-Hao; Hayashi, Daiki; Cao, Jian; Li, Sheng; McCammon, J Andrew; Dennis, Edward A

发表日期：2024

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Vitamin E functions by association with a novel binding site on the 67 kDa laminin receptor activating diacylglycerol kinase

维生素E通过与67 kDa层粘连蛋白受体上的一个新型结合位点结合而发挥作用，从而激活二酰甘油激酶。

期刊:Journal of Nutritional Biochemistry

影响因子:4.9

doi:10.1016/j.jnutbio.2022.109129

Hayashi, Daiki; Mouchlis, Varnavas D; Okamoto, Seika; Namba, Tomoka; Wang, Liuqing; Li, Sheng; Ueda, Shuji; Yamanoue, Minoru; Tachibana, Hirofumi; Arai, Hiroyuki; Ashida, Hitoshi; Dennis, Edward A; Shirai, Yasuhito

信号转导

发表日期：2022

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Each phospholipase A(2) type exhibits distinct selectivity toward sn-1 ester, alkyl ether, and vinyl ether phospholipids

每种磷脂酶A(2)类型对sn-1酯、烷基醚和乙烯基醚磷脂表现出不同的选择性。

期刊:Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids

影响因子:3.3

doi:10.1016/j.bbalip.2021.159067

Hayashi, Daiki; Mouchlis, Varnavas D; Dennis, Edward A

发表日期：2022

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Advances in de Novo Drug Design: From Conventional to Machine Learning Methods

从头开始的药物设计进展：从传统方法到机器学习方法

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms22041676

Mouchlis, Varnavas D; Afantitis, Antreas; Serra, Angela; Fratello, Michele; Papadiamantis, Anastasios G; Aidinis, Vassilis; Lynch, Iseult; Greco, Dario; Melagraki, Georgia

发表日期：2021

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Omega-3 versus Omega-6 fatty acid availability is controlled by hydrophobic site geometries of phospholipase A(2)s

ω-3 与 ω-6 脂肪酸的可用性受磷脂酶 A(2) 疏水位点几何结构的控制。

期刊:Journal of Lipid Research

影响因子:4.1

doi:10.1016/j.jlr.2021.100113

Hayashi, Daiki; Mouchlis, Varnavas D; Dennis, Edward A

代谢

发表日期：2021

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Computer-Aided Drug Design of β-Secretase, γ-Secretase and Anti-Tau Inhibitors for the Discovery of Novel Alzheimer's Therapeutics

利用计算机辅助药物设计β-分泌酶、γ-分泌酶和抗tau蛋白抑制剂，探索新型阿尔茨海默病疗法

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms21030703

Mouchlis, Varnavas D; Melagraki, Georgia; Zacharia, Lefteris C; Afantitis, Antreas

阿尔茨海默症

发表日期：2020

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Lipidomics-based assays coupled with computational approaches can identify novel phospholipase A(2) inhibitors

基于脂质组学的检测方法结合计算方法可以鉴定出新型磷脂酶A(2)抑制剂。

期刊:Advances in Biological Regulation

影响因子:2.4

doi:10.1016/j.jbior.2020.100719

Mouchlis, Varnavas D; Mu, Carol; Hammons, Renee; Dennis, Edward A

发表日期：2020

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Substrate-Specific Inhibition Constants for Phospholipase A(2) Acting on Unique Phospholipid Substrates in Mixed Micelles and Membranes Using Lipidomics

利用脂质组学方法测定磷脂酶A(2)在混合胶束和膜中作用于独特磷脂底物的底物特异性抑制常数

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.8b01568

Mouchlis, Varnavas D; Armando, Aaron; Dennis, Edward A

发表日期：2019

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Phospholipase A(2) catalysis and lipid mediator lipidomics

磷脂酶A(2)催化和脂质介质脂质组学

期刊:Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids

影响因子:3.3

doi:10.1016/j.bbalip.2018.08.010

Mouchlis, Varnavas D; Dennis, Edward A

发表日期：2019

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Unraveling Unique Effect of Ergosterol on Lipid Membranes, and What We Can Do with the Future STS

揭示麦角甾醇对脂质膜的独特作用，以及我们未来可以利用STS做什么

The mechanism of allosteric regulation of calcium-independent phospholipase A(2) by ATP and calmodulin binding to the ankyrin domain

ATP和钙调蛋白与锚蛋白结构域结合，对钙非依赖性磷脂酶A2进行变构调节的机制

Vitamin E functions by association with a novel binding site on the 67 kDa laminin receptor activating diacylglycerol kinase

维生素E通过与67 kDa层粘连蛋白受体上的一个新型结合位点结合而发挥作用，从而激活二酰甘油激酶。

Each phospholipase A(2) type exhibits distinct selectivity toward sn-1 ester, alkyl ether, and vinyl ether phospholipids

每种磷脂酶A(2)类型对sn-1酯、烷基醚和乙烯基醚磷脂表现出不同的选择性。

Advances in de Novo Drug Design: From Conventional to Machine Learning Methods

从头开始的药物设计进展：从传统方法到机器学习方法

Omega-3 versus Omega-6 fatty acid availability is controlled by hydrophobic site geometries of phospholipase A(2)s

ω-3 与 ω-6 脂肪酸的可用性受磷脂酶 A(2) 疏水位点几何结构的控制。

Computer-Aided Drug Design of β-Secretase, γ-Secretase and Anti-Tau Inhibitors for the Discovery of Novel Alzheimer's Therapeutics

利用计算机辅助药物设计β-分泌酶、γ-分泌酶和抗tau蛋白抑制剂，探索新型阿尔茨海默病疗法

Lipidomics-based assays coupled with computational approaches can identify novel phospholipase A(2) inhibitors

基于脂质组学的检测方法结合计算方法可以鉴定出新型磷脂酶A(2)抑制剂。

Substrate-Specific Inhibition Constants for Phospholipase A(2) Acting on Unique Phospholipid Substrates in Mixed Micelles and Membranes Using Lipidomics

利用脂质组学方法测定磷脂酶A(2)在混合胶束和膜中作用于独特磷脂底物的底物特异性抑制常数

Phospholipase A(2) catalysis and lipid mediator lipidomics

磷脂酶A(2)催化和脂质介质脂质组学