日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Inactive structures of the vasopressin V2 receptor reveal distinct binding modes for Tolvaptan and Mambaquaretin toxin.

血管加压素 V2 受体的非活性结构揭示了托伐普坦和曼巴奎汀毒素的不同结合模式

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-59114-5
Fouillen Aurélien, Bous Julien, Couvineau Pierre, Orcel Hélène, Mary Charline, Lafleur Lucie, Pierre Timothé, Mendre Christiane, Gilles Nicolas, Schulte Gunnar, Granier Sébastien, Mouillac Bernard
其它
血管生成
发表日期：2025
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A Snake Toxin Derivative for Treatment of Hyponatremia and Polycystic Kidney Diseases

一种用于治疗低钠血症和多囊肾病的蛇毒衍生物

期刊:Journal of the American Society of Nephrology
影响因子:9.4
doi:10.1681/ASN.0000000505
Stanajic-Petrovic, Goran; Keck, Mathilde; Barbe, Peggy; Urman, Apolline; Correia, Evelyne; Isnard, Pierre; Duong Van Huyen, Jean-Paul; Chmeis, Khawla; Diarra, Sékou Siramakan; Palea, Stefano; Theodoro, Frederic; Nguyen, Anvi-Laëtitia; Castelli, Florence; Pruvost, Alain; Zhao, Wenchao; Mendre, Christiane; Mouillac, Bernard; Bienaimé, Frank; Robin, Philippe; Kessler, Pascal; Llorens-Cortes, Catherine; Servent, Denis; Nozach, Hervé; Maillère, Bernard; Guo, Dong; Truillet, Charles; Gilles, Nicolas
发表日期：2025
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TR-FRET between engineered nanobodies reveals the existence of endogenous CXCR4 oligomers

利用工程纳米抗体之间的时间分辨荧光共振能量转移（TR-FRET）技术揭示了内源性CXCR4寡聚体的存在。

期刊:Communications Biology
影响因子:5.1
doi:10.1038/s42003-025-09166-6
Heuninck, Joyce; Bobkov, Vladimir; Grison, Claire M; Fumagalli, Amos; Lescuyer, Mathias; Otun, Omolade; Bechara, Cherine; Lamarque, Laurent; Trinquet, Eric; Bachelerie, Françoise; Marin, Philippe; Mouillac, Bernard; Granier, Sébastien; van der Woning, Bas; de Haard, Hans; Smit, Martine J; Heukers, Raimond; Durroux, Thierry
CXCR4
IF
RET
发表日期：2025
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Biased activation of the vasopressin V2 receptor probed by molecular dynamics simulations, NMR and pharmacological studies.

通过分子动力学模拟、核磁共振和药理学研究探究加压素 V2 受体的偏向性激活

期刊:Computational and Structural Biotechnology Journal
影响因子:4.1
doi:10.1016/j.csbj.2024.10.039
Fouillen Aurélien, Couvineau Pierre, Gaibelet Gérald, Riché Stéphanie, Orcel Hélène, Mendre Christiane, Kanso Ali, Lanotte Romain, Nguyen Julie, Dimon Juliette, Urbach Serge, Sounier Rémy, Granier Sébastien, Bonnet Dominique, Cong Xiaojing, Mouillac Bernard, Déméné Hélène
信号转导
发表日期：2024
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Bringing GPCR Structural Biology to Medical Applications: Insights from Both V2 Vasopressin and Mu-Opioid Receptors

将GPCR结构生物学应用于医学领域：来自V2血管加压素受体和μ-阿片受体的启示

期刊:Membranes
影响因子:3.6
doi:10.3390/membranes13060606
Fouillen, Aurélien; Bous, Julien; Granier, Sébastien; Mouillac, Bernard; Sounier, Remy
信号转导
GPCR/Calcium/cAMP
发表日期：2023
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Functional Rescue of a Nephrogenic Diabetes Insipidus Causing Mutation in the V2 Vasopressin Receptor by Specific Antagonist and Agonist Pharmacochaperones

特异性拮抗剂和激动剂药理伴侣对V2血管加压素受体中导致肾性尿崩症的突变进行功能性挽救

期刊:Frontiers in Pharmacology
影响因子:4.8
doi:10.3389/fphar.2022.811836
Szalai, Laura; Sziráki, András; Erdélyi, László Sándor; Kovács, Kinga Bernadett; Tóth, Miklós; Tóth, András Dávid; Turu, Gábor; Bonnet, Dominique; Mouillac, Bernard; Hunyady, László; Balla, András
信号转导
发表日期：2022
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Carbohydrate-Based NK1R Antagonists with Broad-Spectrum Anticancer Activity

具有广谱抗癌活性的碳水化合物基NK1R拮抗剂

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.1c00793
Recio, Rocío; Lerena, Patricia; Pozo, Esther; Calderón-Montaño, José Manuel; Burgos-Morón, Estefanía; López-Lázaro, Miguel; Valdivia, Victoria; Pernia Leal, Manuel; Mouillac, Bernard; Organero, Juan Ángel; Khiar, Noureddine; Fernández, Inmaculada
肿瘤
NK1R
NK1
肿瘤免疫
发表日期：2021
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Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active receptor:Gq complex

生长素释放肽受体构象动力学调控受体-Gq复合物从预组装状态向活性状态的转变。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.1414618112
Damian, Marjorie; Mary, Sophie; Maingot, Mathieu; M'Kadmi, Céline; Gagne, Didier; Leyris, Jean-Philippe; Denoyelle, Séverine; Gaibelet, Gérald; Gavara, Laurent; Garcia de Souza Costa, Mauricio; Perahia, David; Trinquet, Eric; Mouillac, Bernard; Galandrin, Ségolène; Galès, Céline; Fehrentz, Jean-Alain; Floquet, Nicolas; Martinez, Jean; Marie, Jacky; Banères, Jean-Louis
信号转导
发表日期：2015
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Time-resolved FRET between GPCR ligands reveals oligomers in native tissues

利用GPCR配体之间的时间分辨FRET技术揭示天然组织中的寡聚体

期刊:Nature Chemical Biology
影响因子:13.7
doi:10.1038/nchembio.396
Albizu, Laura; Cottet, Martin; Kralikova, Michaela; Stoev, Stoytcho; Seyer, René; Brabet, Isabelle; Roux, Thomas; Bazin, Hervé; Bourrier, Emmanuel; Lamarque, Laurent; Breton, Christophe; Rives, Marie-Laure; Newman, Amy; Javitch, Jonathan; Trinquet, Eric; Manning, Maurice; Pin, Jean-Philippe; Mouillac, Bernard; Durroux, Thierry
GPCR/Calcium/cAMP
RET
发表日期：2010
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Biased agonist pharmacochaperones of the AVP V2 receptor may treat congenital nephrogenic diabetes insipidus

AVP V2受体的偏向性激动剂药理伴侣可能用于治疗先天性肾性尿崩症

期刊:Journal of the American Society of Nephrology
影响因子:9.4
doi:10.1681/ASN.2008121289
Jean-Alphonse, Frédéric; Perkovska, Sanja; Frantz, Marie-Céline; Durroux, Thierry; Méjean, Catherine; Morin, Denis; Loison, Stéphanie; Bonnet, Dominique; Hibert, Marcel; Mouillac, Bernard; Mendre, Christiane
信号转导
发表日期：2009
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