Phosphoproteomics of aged insulin-resistant bone identifies P70S6K phosphorylation of AFF4 as a gene-specific transcriptional regulator.
老年胰岛素抵抗骨骼的磷酸化蛋白质组学研究发现,AFF4 的 P70S6K 磷酸化是一种基因特异性转录调节因子。
期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-68106-4
Dutt Mriga, Liao Luoping, Kim Hani Jieun, Blazev Ronnie, Chan Audrey, Kore Hitesh, Bezawork-Geleta Ayenachew, Dong Li, Rivera Isela Sarahi, Wee Natalie K Y, Molendijk Jeffrey, Wong Julian P H, Haynes Vanessa R, Uribe Veronica, Lynch Gordon S, Smith Kelly A, Montgomery Magdalene K, Watt Matthew J, Yang Pengyi, Dodd Garron T, Vervoort Stephin J, Sims Natalie A, Parker Benjamin L