日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Immunoproteasome inhibition triggers protein stress and apoptosis in cells of B cell lineage without impairing vaccination-induced antibody responses

免疫蛋白酶体抑制可诱导B细胞谱系细胞发生蛋白质应激和凋亡,但不会影响疫苗诱导的抗体反应。

Mink, Dennis; Oliveri, Franziska; Otto, Julia; Kutsi, Nazlim; Gonzalez Siebold, Carolina; Muchamuel, Tony; Li, Jun; Basler, Michael

Immunoproteasome Inhibition Impairs Differentiation but Not Survival of T Helper 17 Cells

免疫蛋白酶体抑制会损害T辅助细胞17的分化,但不会影响其存活。

Oliveri, Franziska; Mink, Dennis; Muchamuel, Tony; Basler, Michael

Signal peptide mimicry primes Sec61 for client-selective inhibition

信号肽模拟引发 Sec61 进行客户端选择性抑制

Shahid Rehan, Dale Tranter, Phillip P Sharp, Gregory B Craven, Eric Lowe, Janet L Anderl, Tony Muchamuel, Vahid Abrishami, Suvi Kuivanen, Nicole A Wenzell, Andy Jennings, Chakrapani Kalyanaraman, Tomas Strandin, Matti Javanainen, Olli Vapalahti, Matthew P Jacobson, Dustin McMinn, Christopher J Kirk,

Zetomipzomib (KZR-616) attenuates lupus in mice via modulation of innate and adaptive immune responses.

Zetomipzomib (KZR-616) 通过调节先天性和适应性免疫反应来减轻小鼠的狼疮症状

Muchamuel Tony, Fan R Andrea, Anderl Janet L, Bomba Darrin J, Johnson Henry W B, Lowe Eric, Tuch Brian B, McMinn Dustin L, Millare Beatriz, Kirk Christopher J

Discovery and Early Clinical Development of Selective Immunoproteasome Inhibitors

选择性免疫蛋白酶体抑制剂的发现和早期临床开发

Kirk, Christopher J; Muchamuel, Tony; Wang, Jinhai; Fan, R Andrea

Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis

抑制免疫蛋白酶体可改善实验性自身免疫性脑脊髓炎

Basler, Michael; Mundt, Sarah; Muchamuel, Tony; Moll, Carlo; Jiang, Jing; Groettrup, Marcus; Kirk, Christopher J

Beneficial effect of novel proteasome inhibitors in murine lupus via dual inhibition of type I interferon and autoantibody-secreting cells

新型蛋白酶体抑制剂通过双重抑制I型干扰素和自身抗体分泌细胞,对小鼠狼疮发挥有益作用

Ichikawa, H Travis; Conley, Thomas; Muchamuel, Tony; Jiang, Jing; Lee, Susan; Owen, Teresa; Barnard, Jennifer; Nevarez, Sarah; Goldman, Bruce I; Kirk, Christopher J; Looney, R John; Anolik, Jennifer H

Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: a link to clinical adverse events

蛋白酶体抑制剂硼替佐米和卡非佐米的非蛋白酶体靶点:与临床不良事件的联系

Shirin Arastu-Kapur, Janet L Anderl, Marianne Kraus, Francesco Parlati, Kevin D Shenk, Susan J Lee, Tony Muchamuel, Mark K Bennett, Christoph Driessen, Andrew J Ball, Christopher J Kirk

Cytokine networking in lungs of immunocompetent mice in response to inhaled Aspergillus fumigatus

免疫功能正常的鼠吸入烟曲霉后肺部细胞因子网络的变化

Brieland, J K; Jackson, C; Menzel, F; Loebenberg, D; Cacciapuoti, A; Halpern, J; Hurst, S; Muchamuel, T; Debets, R; Kastelein, R; Churakova, T; Abrams, J; Hare, R; O'Garra, A

Continuous administration of anti-interleukin 10 antibodies delays onset of autoimmunity in NZB/W F1 mice

持续注射抗白细胞介素 10 抗体可延缓 NZB/W F1 小鼠自身免疫性疾病的发生。

Ishida, H; Muchamuel, T; Sakaguchi, S; Andrade, S; Menon, S; Howard, M