日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Age-specific induction of mutant p53 drives clonal hematopoiesis and acute myeloid leukemia in adult mice

成年小鼠中突变型p53的年龄特异性诱导驱动克隆性造血和急性髓系白血病

Rasoul Pourebrahim ,Rafael Heinz Montoya ,Hiroki Akiyama ,Lauren Ostermann ,Shayuan Khazaei ,Muharrem Muftuoglu ,Natalia Baran ,Ran Zhao ,Tom Lesluyes ,Bin Liu ,Joseph D Khoury ,Mihai Gagea ,Peter Van Loo ,Michael Andreeff

Combined inhibition of BCL-2 and MCL-1 overcomes BAX deficiency-mediated resistance of TP53-mutant acute myeloid leukemia to individual BH3 mimetics

联合抑制 BCL-2 和 MCL-1 可克服 BAX 缺陷介导的 TP53 突变型急性髓系白血病对单一 BH3 模拟物的耐药性。

Bing Z Carter ,Po Yee Mak ,Wenjing Tao ,Edward Ayoub ,Lauren B Ostermann ,Xuelin Huang ,Sanam Loghavi ,Steffen Boettcher ,Yuki Nishida ,Vivian Ruvolo ,Paul E Hughes ,Phuong K Morrow ,Torsten Haferlach ,Steven Kornblau ,Muharrem Muftuoglu ,Michael Andreeff

Enhanced TP53 reactivation disrupts MYC transcriptional program and overcomes venetoclax resistance in acute myeloid leukemias

TP53 的重新激活增强会破坏 MYC 转录程序并克服急性髓系白血病中的维奈托克耐药性

Yuki Nishida ,Jo Ishizawa ,Edward Ayoub ,Rafael Heinz Montoya ,Lauren B Ostermann ,Muharrem Muftuoglu ,Vivian R Ruvolo ,Tallie Patsilevas ,Darah A Scruggs ,Shayaun Khazaei ,Po Yee Mak ,Wenjing Tao ,Bing Z Carter ,Steffen Boettcher ,Benjamin L Ebert ,Naval G Daver ,Marina Konopleva ,Takahiko Seki ,Kensuke Kojima ,Michael Andreeff

In-depth analysis of SARS-CoV-2-specific T cells reveals diverse differentiation hierarchies in vaccinated individuals

对SARS-CoV-2特异性T细胞的深入分析揭示了接种疫苗个体中不同的分化层级

Li Li ,Muharrem Muftuoglu ,Shaoheng Liang ,Mahesh Basyal ,Jiangxing Lv ,Mehmet Emin Akdogan ,Ken Chen ,Michael Andreeff ,Christopher R Flowers ,Simrit Parmar

Clinical Efficacy and Tumor Microenvironment Influence in a Dose-Escalation Study of Anti-CD19 Chimeric Antigen Receptor T Cells in Refractory B-Cell Non-Hodgkin's Lymphoma

抗 CD19 嵌合抗原受体 T 细胞治疗难治性 B 细胞非霍奇金淋巴瘤的剂量递增研究的临床疗效及肿瘤微环境影响

Zi-Xun Yan #, Li Li #, Wen Wang #, Bin-Shen OuYang #, Shu Cheng, Li Wang, Wen Wu, Peng-Peng Xu, Muharrem Muftuoglu, Ming Hao, Su Yang, Mu-Chen Zhang, Zhong Zheng, James Li, Wei-Li Zhao

The CXCR4-STAT3-IL-10 Pathway Controls the Immunoregulatory Function of Chronic Lymphocytic Leukemia and Is Modulated by Lenalidomide

CXCR4-STAT3-IL-10 通路控制慢性淋巴细胞白血病的免疫调节功能并受来那度胺的调节

Hila Shaim, Zeev Estrov, David Harris, Mayra Hernandez Sanabria, Zhiming Liu, Peter Ruvolo, Phillip A Thompson, Alessandra Ferrajoli, May Daher, Jan Burger, Muharrem Muftuoglu, Nobuhiko Imahashi, Li Li, Enli Liu, Abdullah Saleh Alsuliman, Rafet Basar, Lucila Nassif Kerbauy, Catherine Sobieski, Elif

Evidence for B Cell Exhaustion in Chronic Graft-versus-Host Disease

慢性移植物抗宿主病中 B 细胞耗竭的证据

Ahmad Khoder, Abdullah Alsuliman, Rafet Basar, Catherine Sobieski, Kayo Kondo, Amin Majid Alousi, Richard Szydlo, Muharrem Muftuoglu, Hila Shaim, Jane F Apperley, Elif Gokdemir, Nichola Cooper, Rohtesh S Mehta, David Marin, Richard Champlin, Elizabeth Shpall, Katayoun Rezvani

IL-10+ regulatory B cells are enriched in cord blood and may protect against cGVHD after cord blood transplantation

IL-10+ 调节性 B 细胞在脐带血中富集,可能在脐带血移植后预防 cGVHD

Anushruti Sarvaria, Rafet Basar, Rohtesh S Mehta, Hila Shaim, Muharrem Muftuoglu, Ahmad Khoder, Takuye Sekine, Elif Gokdemir, Kayo Kondo, David Marin, May Daher, Amin M Alousi, Abdullah Alsuliman, Enli Liu, Betul Oran, Amanda Olson, Roy B Jones, Uday Popat, Chitra Hosing, Richard Champlin, Elizabeth

Specific combinations of donor and recipient KIR-HLA genotypes predict for large differences in outcome after cord blood transplantation

供体和受体 KIR-HLA 基因型的特定组合可预测脐带血移植后结果的巨大差异

Takuya Sekine, David Marin, Kai Cao, Li Li, Pramod Mehta, Hila Shaim, Catherine Sobieski, Roy Jones, Betul Oran, Chitra Hosing, Gabriela Rondon, Abdullah Alsuliman, Silke Paust, Borje Andersson, Uday Popat, Partow Kebriaei, Muharrem Muftuoglu, Rafet Basar, Kayo Kondo, Yago Nieto, Nina Shah, Amanda O

Regulatory B cells are enriched within the IgM memory and transitional subsets in healthy donors but are deficient in chronic GVHD

在健康供体的 IgM 记忆和过渡亚群中,调节性 B 细胞丰富,但在慢性 GVHD 中则缺乏

Ahmad Khoder, Anushruti Sarvaria, Abdullah Alsuliman, Claude Chew, Takuya Sekine, Nichola Cooper, Stephan Mielke, Hugues de Lavallade, Muharrem Muftuoglu, Irina Fernandez Curbelo, Enli Liu, Paolo A Muraro, Amin Alousi, Kate Stringaris, Simrit Parmar, Nina Shah, Hila Shaim, Eric Yvon, Jeffrey Molldre