Frustration in the protein-protein interface plays a central role in the cooperativity of PROTAC ternary complexes
蛋白质-蛋白质界面处的相互作用受阻在PROTAC三元复合物的协同作用中起着核心作用。
期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-63713-7
Ma, Ning; Bhattacharya, Supriyo; Muk, Sanychen; Jandova, Zuzana; Schmalhorst, Philipp S; Ghosh, Soumadwip; Le, Keith; Diers, Emelyne; Trainor, Nicole; Farnaby, William; Roy, Michael J; Kofink, Christiane; Greb, Peter; Weinstabl, Harald; Ciulli, Alessio; Bader, Gerd; Sankar, Kyra; Bergner, Andreas; Vaidehi, Nagarajan