日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Experimental evolution in the cystic fibrosis chemical environment reveals early TCA cycle flux as a central regulator of Mycobacterium abscessus biofilm formation

囊性纤维化化学环境下的实验进化表明,早期三羧酸循环通量是脓肿分枝杆菌生物膜形成的核心调控因子。

Wang, Yu-Hao; D'Amico, Isabelle; Whalen, Jocelyn; Mullett, Steven J; Gelhaus, Stacy L; Cooper, Vaughn S; Armbruster, Catherine R; DePas, William H

Reversible dissociation of mitochondrial Complex V balances anabolic and energy-generating needs in cancer.

线粒体复合物 V 的可逆解离平衡了癌症中的合成代谢和能量产生需求。

Wang Huabo, Lu Jie, Henchy Colin, Mullett Steven J, Richert Adam C, Goetzman Eric S, Toksoz Ahmet, Hale Leonardo, Wang Brandon B, Mnatsakanyan Nelli, Prochownik Edward V

Nitroalkene inhibition of pro-inflammatory macrophage effector function via modulation of signaling metabolite levels.

硝基烯烃通过调节信号代谢物水平抑制促炎巨噬细胞效应功能。

Stevenson Emily R, O'Brien James P, Manuel Allison M, Uvalle Crystal E, Buchan Gregory J, Mullett Steven J, Lockwood Karina, Suber Tomeka, Freeman Bruce A, Gelhaus Stacy L

Discovery and validation of small molecule stabilizers of mutant triose phosphate isomerase (TPI) as potential lead candidates for TPI deficiency

发现并验证突变型磷酸丙糖异构酶 (TPI) 小分子稳定剂作为 TPI 缺乏症的潜在先导化合物

Vollmer, Laura L; Roberts, Presley; Eicher, Samantha L; Wołosowicz, Marta; Patel, Priyal; Figura, Joseph R; Donahue, Ella R; Berkowitz, Josh; Gavlock, Dillon; Wipf, Peter; LaPorte, Matt; Mullett, Steven J; Shillington, Amelle; Homanics, Gregg E; Palladino, Michael J; Vogt, Andreas

CYB5R4 sustains endothelial proliferation and ischemia-induced angiogenesis by maintaining RRM2-dependent nucleotide balance.

CYB5R4 通过维持 RRM2 依赖的核苷酸平衡来维持内皮细胞增殖和缺血诱导的血管生成。

Yuan Shuai, Hahn Scott A, Colussi Nicole C, Mullett Steven J, Gelhaus Stacy L, Schopfer Francisco J, Straub Adam C

Intracellular glutamine fluctuates with nitrogen availability and regulates Mycobacterium smegmatis biofilm formation.

细胞内谷氨酰胺随氮的供应而波动,并调节耻垢分枝杆菌生物膜的形成

Varner Elizabeth, Meyer Mitchell, Whalen Jocelyn, Wang Yu-Hao, Rodriguez Carlos, Malik Ifra, Mullett Steven J, Gelhaus Stacy L, DePas William H

Dietary dicarboxylic acids provide a nonstorable alternative fat source that protects mice against obesity

膳食二羧酸提供了一种不可储存的替代脂肪来源,可以保护小鼠免受肥胖的侵害。

Goetzman, Eric S; Zhang, Bob B; Zhang, Yuxun; Bharathi, Sivakama S; Bons, Joanna; Rose, Jacob; Shah, Samah; Solo, Keaton J; Schmidt, Alexandra V; Richert, Adam C; Mullett, Steven J; Gelhaus, Stacy L; Rao, Krithika S; Shiva, Sruti S; Pfister, Katherine E; Silva Barbosa, Anne; Sims-Lucas, Sunder; Dobrowolski, Steven F; Schilling, Birgit

An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma.

ERK5-PFKFB3 轴调节糖酵解,是儿童弥漫性中线胶质瘤的治疗弱点。

Casillo Stephanie M, Gatesman Taylor A, Chilukuri Akanksha, Varadharajan Srinidhi, Johnson Brenden J, David Premkumar Daniel R, Jane Esther P, Plute Tritan J, Koncar Robert F, Stanton Ann-Catherine J, Biagi-Junior Carlos A O, Barber Callie S, Halbert Matthew E, Golbourn Brian J, Halligan Katharine, Cruz Andrea F, Mansi Neveen M, Cheney Allison, Mullett Steven J, Land Clinton Van't, Perez Jennifer L, Myers Max I, Agrawal Nishant, Michel Joshua J, Chang Yue-Fang, Vaske Olena M, MichaelRaj Antony, Lieberman Frank S, Felker James, Shiva Sruti, Bertrand Kelsey C, Amankulor Nduka, Hadjipanayis Costas G, Abdullah Kalil G, Zinn Pascal O, Friedlander Robert M, Abel Taylor J, Nazarian Javad, Venneti Sriram, Filbin Mariella G, Gelhaus Stacy L, Mack Stephen C, Pollack Ian F, Agnihotri Sameer

Sex-based differences in persistent lung inflammation following influenza infection of juvenile outbred mice

幼年近交系小鼠感染流感后持续性肺部炎症的性别差异

Huckestein, Brydie R; Antos, Danielle; Manni, Michelle L; Zeng, Kelly; Miller, Leigh M; Parenteau, Kristen L; Gelhaus, Stacy L; Mullett, Steven J; Shoemaker, Jason E; Alcorn, John F

Vitamin C Is Mandatory for the Tricarboxylic Acid Cycle Production of Antiinflammatory Itaconate

维生素C是三羧酸循环中抗炎物质衣康酸合成的必需物质。

Soysal, Elif; Castellano, Elizabeth; Korkmaz, Aybike; Mullett, Steven J; Kim-Campbell, Nahmah; Epperly, Michael; Wendell, Stacy; Kagan, Valerian E; Bayır, Hülya