日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

The Recycling Collagen Receptor uPARAP Is a Unique Mediator of Stromal Drug Delivery to Carcinoma Cells.

回收胶原蛋白受体 uPARAP 是基质药物递送至癌细胞的独特介质。

期刊:Molecular Cancer Therapeutics
影响因子:5.5
doi:10.1158/1535-7163.MCT-25-0051
Nørregaard Kirstine S, Larsen Ida M E, Jürgensen Henrik J, Blomquist Michaela Hansen, Çakilkaya Pinar, Metrangolo Virginia, Perlado Alba Martinez, Krigslund Oliver, Gårdsvoll Henrik, Poulsen Thomas T, Mumberg Dominik, Santoni-Rugiu Eric, Engelholm Lars H, Behrendt Niels
肿瘤
肿瘤免疫
信号转导
uPA
细胞生物学
uPAR
发表日期：2026
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Molecular epidemiology of the expression of urokinase plasminogen activator receptor-associated protein (uPARAP) in mesenchymal malignancies

间质恶性肿瘤中尿激酶型纤溶酶原激活物受体相关蛋白（uPARAP）表达的分子流行病学

期刊:Translational Oncology
影响因子:4.1
doi:10.1016/j.tranon.2026.102708
Wang, Chao-Chi; Barkholt, Pernille; Wozniak, Agnieszka; Vanleeuw, Ulla; Lee, Che-Jui; De Sutter, Luna; De Cock, Lore; Verbeeck, Kimberly; Engelholm, Lars Henning; Lynch, Carmel; Mumberg, Dominik; Schöffski, Patrick
肿瘤
肿瘤免疫
信号转导
uPA
uPAR
发表日期：2026
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Mono- and multimeric PSMA-targeting small molecule-thorium-227 conjugates for optimized efficacy and biodistribution in preclinical models

单体和多聚体PSMA靶向小分子-钍-227偶联物在临床前模型中优化疗效和生物分布

期刊:European Journal of Nuclear Medicine and Molecular Imaging
影响因子:7.6
doi:10.1007/s00259-023-06474-z
Böhnke, Niels; Indrevoll, Bård; Hammer, Stefanie; Papple, Alex; Kristian, Alexander; Briem, Hans; Celik, Arif; Mumberg, Dominik; Cuthbertson, Alan; Zitzmann-Kolbe, Sabine
发表日期：2024
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A Targeted Thorium-227 Conjugate Demonstrates Efficacy in Preclinical Models of Acquired Drug Resistance and Combination Potential with Chemotherapeutics and Antiangiogenic Therapies.

靶向钍-227偶联物在获得性耐药的临床前模型中显示出疗效，并具有与化疗药物和抗血管生成疗法联合应用的潜力

期刊:Molecular Cancer Therapeutics
影响因子:5.5
doi:10.1158/1535-7163.MCT-22-0808
Zitzmann-Kolbe Sabine, Kristian Alexander, Zopf Dieter, Kamfenkel Claudia, Politz Oliver, Ellingsen Christine, Hilbig Jochen, Juul Mark U, Fonslet Jesper, Nielsen Carsten H, Schatz Christoph A, Bjerke Roger M, Cuthbertson Alan S, Mumberg Dominik, Hagemann Urs B
心血管
血管生成
发表日期：2023
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Zoledronic Acid Prevents Bone Resorption Caused by the Combination of Radium-223, Abiraterone Acetate, and Prednisone in an Intratibial Prostate Cancer Mouse Model

在胫骨内前列腺癌小鼠模型中，唑来膦酸可预防镭-223、醋酸阿比特龙和泼尼松联合用药引起的骨吸收

期刊:Cancers
影响因子:4.4
doi:10.3390/cancers15164115
Suominen, Mari I; Knuuttila, Matias; Sjöholm, Birgitta; Wilson, Timothy; Alhoniemi, Esa; Mumberg, Dominik; Käkönen, Sanna-Maria; Scholz, Arne
Mouse
肿瘤
前列腺癌
肿瘤免疫
发表日期：2023
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A Novel NAMPT Inhibitor-Based Antibody-Drug Conjugate Payload Class for Cancer Therapy

一种新型的基于NAMPT抑制剂的抗体-药物偶联物有效载荷用于癌症治疗

期刊:Bioconjugate Chemistry
影响因子:3.9
doi:10.1021/acs.bioconjchem.2c00178
Böhnke, Niels; Berger, Markus; Griebenow, Nils; Rottmann, Antje; Erkelenz, Michael; Hammer, Stefanie; Berndt, Sandra; Günther, Judith; Wengner, Antje M; Stelte-Ludwig, Beatrix; Mahlert, Christoph; Greven, Simone; Dietz, Lisa; Jörißen, Hannah; Barak, Naomi; Bömer, Ulf; Hillig, Roman C; Eberspaecher, Uwe; Weiske, Jörg; Giese, Anja; Mumberg, Dominik; Nising, Carl Friedrich; Weinmann, Hilmar; Sommer, Anette
NAMPT
肿瘤
肿瘤免疫
发表日期：2022
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Immunostimulatory effects of targeted thorium-227 conjugates as single agent and in combination with anti-PD-L1 therapy

靶向钍-227偶联物作为单药及与抗PD-L1疗法联合应用时的免疫刺激作用

期刊:Journal for ImmunoTherapy of Cancer
影响因子:10.6
doi:10.1136/jitc-2021-002387
Lejeune, Pascale; Cruciani, Véronique; Berg-Larsen, Axel; Schlicker, Andreas; Mobergslien, Anne; Bartnitzky, Lisa; Berndt, Sandra; Zitzmann-Kolbe, Sabine; Kamfenkel, Claudia; Stargard, Stefan; Hammer, Stefanie; Jørgensen, Jennifer S; Jackerott, Malene; Nielsen, Carsten H; Schatz, Christoph A; Hennekes, Hartwig; Karlsson, Jenny; Cuthbertson, Alan S; Mumberg, Dominik; Hagemann, Urs B
PD-L1
免疫/内分泌
发表日期：2021
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The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models

强效 AMPK 抑制剂 BAY-3827 在雄激素依赖性前列腺癌模型中显示出显著疗效。

期刊:Cellular Oncology
影响因子:4.8
doi:10.1007/s13402-020-00584-8
Lemos, Clara; Schulze, Volker K; Baumgart, Simon J; Nevedomskaya, Ekaterina; Heinrich, Tobias; Lefranc, Julien; Bader, Benjamin; Christ, Clara D; Briem, Hans; Kuhnke, Lara P; Holton, Simon J; Bömer, Ulf; Lienau, Philip; von Nussbaum, Franz; Nising, Carl F; Bauser, Marcus; Hägebarth, Andrea; Mumberg, Dominik; Haendler, Bernard
肿瘤
肿瘤免疫
AMPK
前列腺癌
免疫/内分泌
发表日期：2021
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IL3RA-Targeting Antibody-Drug Conjugate BAY-943 with a Kinesin Spindle Protein Inhibitor Payload Shows Efficacy in Preclinical Models of Hematologic Malignancies

靶向IL3RA的抗体药物偶联物BAY-943，携带驱动蛋白纺锤体蛋白抑制剂有效载荷，在血液系统恶性肿瘤的临床前模型中显示出疗效。

期刊:Cancers
影响因子:4.4
doi:10.3390/cancers12113464
Kirchhoff, Dennis; Stelte-Ludwig, Beatrix; Lerchen, Hans-Georg; Wengner, Antje Margret; Ahsen, Oliver von; Buchmann, Pascale; Märsch, Stephan; Mahlert, Christoph; Greven, Simone; Dietz, Lisa; Erkelenz, Michael; Zierz, Ruprecht; Johanssen, Sandra; Mumberg, Dominik; Sommer, Anette
肿瘤
IL3
肿瘤免疫
IL3RA
发表日期：2020
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Advances in Precision Oncology: Targeted Thorium-227 Conjugates As a New Modality in Targeted Alpha Therapy

精准肿瘤学进展：靶向钍-227偶联物作为靶向α疗法的新模式

期刊:Cancer Biotherapy and Radiopharmaceuticals
影响因子:2.1
doi:10.1089/cbr.2020.3568
Hagemann, Urs B; Wickstroem, Katrine; Hammer, Stefanie; Bjerke, Roger M; Zitzmann-Kolbe, Sabine; Ryan, Olav B; Karlsson, Jenny; Scholz, Arne; Hennekes, Hartwig; Mumberg, Dominik; Cuthbertson, Alan S
肿瘤
肿瘤免疫
发表日期：2020
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