A CD8αβ co-receptor modified to contain an intracellular CD28 signaling tail enhances TCR-engineered T cell function independent of solid-tumor-associated co-stimulatory ligands
经过修饰，含有胞内 CD28 信号尾的 CD8αβ 共受体可增强 TCR 工程化 T 细胞的功能，且该功能不依赖于实体瘤相关的共刺激配体。
期刊:Nature Communications
影响因子:14.7
doi:10.1038/s41467-025-67446-5
Shihong Zhang #,Tzu-Hao Tang #,Sinéad Kinsella #,Francesco Mazziotta,Michael T Schweizer,Megan S McAfee,Ariunaa Munkhbat,Yapeng Su,Valentin Voillet,Lauren E Martin,Colton W Smith,Yuta Asano,Menna Hailemariam,Jakob Bakhtiari,Bo Lee,Cecilia Yeung,Hung Chen,Alessandro M Rizzi,Daniel G Chen,Kelsey Furiya,Nick Horst,Tianzi Zhang,Phung Le,Kelly McKenna,Shannon K Oda,Anthony Rongvaux,Phillip D Greenberg,Thomas M Schmitt,Aude G Chapuis
