日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Flt3L-mediated tumor cDC1 expansion enhances immunotherapy by priming stem-like CD8(+) T cells in lymph nodes

Flt3L介导的肿瘤cDC1扩增通过启动淋巴结中的干细胞样CD8(+) T细胞来增强免疫疗法。

Lai, Junyun; Chan, Cheok Weng; Armitage, Jesse D; Audsley, Katherine M; Huang, Yu-Kuan; Derrick, Emily B; Carstensen, Laura S; Scheffler, Christina M; Jones, Matt E; Sek, Kevin; Principe, Nicola; Kim, Joelle S; House, Imran G; Chen, Amanda X Y; Yap, Kah Min; Middelburg, Jim; Munoz, Isabelle; Nguyen, Dat; Tong, Junming; Hoang, Thang X; Todd, Kirsten L; Evrard, Maximilien; Chee, Jonathan; Mackay, Laura K; Forrest, Alistair R R; Parish, Ian A; Bosco, Anthony; Waithman, Jason; Beavis, Paul A; Darcy, Phillip K

High efficiency CRISPR knock-in demonstrates that TCF1 is insufficient to reverse T cell exhaustion.

高效的 CRISPR 基因敲入实验表明,TCF1 不足以逆转 T 细胞耗竭。

de Menezes Maria N, Chen Amanda X Y, Kulkarni Nihali, Sampurno Shienny, Saw Nicole Y L, Yap Kah Min, Pérez-Núñez Iván, Roth Sara, Deguit Christian Deo T, Haugen Brandon, Ramsbottom Kelly M, Munoz Isabelle, Beavis Paul A, Parish Ian A

Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery

通过重编程CAR T细胞中的内源基因,实现肿瘤特异性有效载荷递送。

Chen, Amanda X Y; Yap, Kah Min; Kim, Joelle S; Sek, Kevin; Huang, Yu-Kuan; Dunbar, Phoebe A; Wiebking, Volker; Armitage, Jesse D; Munoz, Isabelle; Todd, Kirsten L; Derrick, Emily B; Nguyen, Dat; Tong, Junming; Chan, Cheok Weng; Hoang, Thang X; Audsley, Katherine M; van Elsas, Marit J; Middelburg, Jim; Lee, Joel N; de Menezes, Maria N; Cole, Thomas J; Li, Jasmine; Scheffler, Christina; Scott, Andrew M; Mackay, Laura K; Waithman, Jason; Oliaro, Jane; Harrison, Simon J; Parish, Ian A; Lai, Junyun; Porteus, Matthew H; House, Imran G; Darcy, Phillip K; Beavis, Paul A

Tumor site-directed A1R expression enhances CAR T cell function and improves efficacy against solid tumors.

肿瘤部位定向的 A1R 表达可增强 CAR T 细胞功能,提高对实体瘤的疗效

Sek Kevin, Chen Amanda X Y, Cole Thomas, Armitage Jesse D, Tong Junming, Yap Kah Min, Munoz Isabelle, Dunbar Phoebe A, Wu Shiyi, van Elsas Marit J, Hidajat Olivia, Scheffler Christina, Giuffrida Lauren, Henderson Melissa A, Meyran Deborah, Souza-Fonseca-Guimaraes Fernando, Nguyen Dat, Huang Yu-Kuan, de Menezes Maria N, Derrick Emily B, Chan Cheok Weng, Todd Kirsten L, Chan Jack D, Li Jasmine, Lai Junyun, Petley Emma V, Mardiana Sherly, Bosco Anthony, Waithman Jason, Parish Ian A, Mølck Christina, Stewart Gregory D, Kats Lev, House Imran G, Darcy Phillip K, Beavis Paul A

The 3,7-diazabicyclo[3.3.1]nonane scaffold for subtype selective nicotinic acetylcholine receptor ligands. Part 2: carboxamide derivatives with different spacer motifs

3,7-二氮杂双环[3.3.1]壬烷骨架用于亚型选择性烟碱乙酰胆碱受体配体。第 2 部分:具有不同间隔基序的羧酰胺衍生物

Christoph Eibl, Lenka Munoz, Isabelle Tomassoli, Clare Stokes, Roger L Papke, Daniela Gündisch