日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Fragment-Based Development of Small Molecule Inhibitors Targeting Mycobacterium tuberculosis Cholesterol Metabolism.

基于片段的小分子抑制剂开发靶向结核分枝杆菌胆固醇代谢

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c00478
Kavanagh Madeline E, McLean Kirsty J, Gilbert Sophie H, Amadi Cecilia N, Snee Matthew, Tunnicliffe Richard B, Arora Kriti, Boshoff Helena I M, Fanourakis Alexander, Rebollo-Lopez Maria Jose, Ortega Fatima, Levy Colin W, Munro Andrew W, Leys David, Abell Chris, Coyne Anthony G
代谢
肠道菌群
发表日期：2025
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Fragment-based development of small molecule inhibitors targeting Mycobacterium tuberculosis cholesterol metabolism

基于片段的小分子抑制剂开发靶向结核分枝杆菌胆固醇代谢

期刊:
影响因子:
doi:10.1101/2024.10.28.620643
Kavanagh, Madeline E; McLean, Kirsty J; Gilbert, Sophie H; Amadi, Cecilia; Snee, Matthew; Tunnicliffe, Richard B; Arora, Kriti; Boshoff, Helena I; Fanourakis, Alexander; Rebello-Lopez, Maria Jose; Ortega-Muro, Fatima; Levy, Colin W; Munro, Andrew W; Leys, David; Abell, Chris; Coyne, Anthony G
代谢
发表日期：2024
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Structure Based Discovery of Inhibitors of CYP125 and CYP142 from Mycobacterium tuberculosis

基于结构的结核分枝杆菌CYP125和CYP142抑制剂的发现

期刊:Chemistry-A European Journal
影响因子:3.7
doi:10.1002/chem.202203868
Katariya, Mona M; Snee, Matthew; Tunnicliffe, Richard B; Kavanagh, Madeline E; Boshoff, Helena I M; Amadi, Cecilia N; Levy, Colin W; Munro, Andrew W; Abell, Chris; Leys, David; Coyne, Anthony G; McLean, Kirsty J
发表日期：2023
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A Promiscuous Bacterial P450: The Unparalleled Diversity of BM3 in Pharmaceutical Metabolism

一种用途广泛的细菌P450：BM3在药物代谢中无与伦比的多样性

期刊:International Journal of Molecular Sciences
影响因子:4.9
doi:10.3390/ijms222111380
Thistlethwaite, Sian; Jeffreys, Laura N; Girvan, Hazel M; McLean, Kirsty J; Munro, Andrew W
代谢
微生物学
发表日期：2021
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Catalytic Mechanism of Aromatic Nitration by Cytochrome P450 TxtE: Involvement of a Ferric-Peroxynitrite Intermediate

细胞色素P450 TxtE催化芳香族硝化反应的机理：铁-过氧亚硝酸盐中间体的参与

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.0c05070
Louka, Savvas; Barry, Sarah M; Heyes, Derren J; Mubarak, M Qadri E; Ali, Hafiz Saqib; Alkhalaf, Lona M; Munro, Andrew W; Scrutton, Nigel S; Challis, Gregory L; de Visser, Sam P
细胞生物学
发表日期：2020
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Design and Synthesis of Imidazole and Triazole Pyrazoles as Mycobacterium Tuberculosis CYP121A1 Inhibitors

设计并合成咪唑和三唑吡唑类化合物作为结核分枝杆菌CYP121A1抑制剂

期刊:ChemistryOpen
影响因子:3.1
doi:10.1002/open.201900227
Kishk, Safaa M; McLean, Kirsty J; Sood, Sakshi; Smith, Darren; Evans, Jack W D; Helal, Mohamed A; Gomaa, Mohamed S; Salama, Ismail; Mostafa, Samia M; de Carvalho, Luiz Pedro S; Levy, Colin W; Munro, Andrew W; Simons, Claire
发表日期：2019
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Synthesis and biological evaluation of novel cYY analogues targeting Mycobacterium tuberculosis CYP121A1

合成和生物学评价靶向结核分枝杆菌CYP121A1的新型cYY类似物

期刊:Bioorganic & Medicinal Chemistry
影响因子:3
doi:10.1016/j.bmc.2019.02.051
Kishk, Safaa M; McLean, Kirsty J; Sood, Sakshi; Helal, Mohamed A; Gomaa, Mohamed S; Salama, Ismail; Mostafa, Samia M; de Carvalho, Luiz Pedro S; Munro, Andrew W; Simons, Claire
发表日期：2019
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Cytochrome P450 1A1 opens up to new substrates

细胞色素P450 1A1 开放以接受新的底物

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1074/jbc.H118.006715
Munro, Andrew W
细胞生物学
发表日期：2018
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Corrigendum: Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors

更正：结核分枝杆菌CYP121抑制剂设计中的底物片段化

期刊:ChemMedChem
影响因子:3.4
doi:10.1002/cmdc.201600619
Kavanagh, Madeline E; Gray, Janine L; Gilbert, Sophie H; Coyne, Anthony G; McLean, Kirsty J; Davis, Holly J; Munro, Andrew W; Abell, Chris
发表日期：2017
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Substrate Fragmentation for the Design of M. tuberculosis CYP121 Inhibitors

结核分枝杆菌CYP121抑制剂设计的底物片段化

期刊:ChemMedChem
影响因子:3.4
doi:10.1002/cmdc.201600248
Kavanagh, Madeline E; Gray, Janine L; Gilbert, Sophie H; Coyne, Anthony G; McLean, Kirsty J; Davis, Holly J; Munro, Andrew W; Abell, Chris
发表日期：2016
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