日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A de novo missense variant in MIDEAS results in increased deacetylase activity of the MiDAC HDAC complex causing a neurodevelopmental syndrome

MIDEAS基因中的一种新发错义突变导致MiDAC HDAC复合物的去乙酰化酶活性增强,从而引起神经发育综合征。

Fairall, Louise; Sirvydis, Kristupas; Turnbull, Robert E; Knottnerus, Suzan Jg; Gonchar, Oksana; Muskett, Frederick W; Jukes-Jones, Rebekah; van Brussel, Lonneke; van de Geer, Ellen; van Gassen, Koen; Badenhorst, Paul; Johnson, Diana; Terhal, Paulien A; van Hasselt, Peter M; van Jaarsveld, Richard H; Schwabe, John Wr

2'-(19)F labelling of ribose in RNAs: a tool to analyse RNA/protein interactions by NMR in physiological conditions

RNA中核糖的2'-(19)F标记:一种在生理条件下利用核磁共振分析RNA/蛋白质相互作用的工具

Kara, Hesna; Axer, Alexander; Muskett, Frederick W; Bueno-Alejo, Carlos J; Paschalis, Vasileios; Taladriz-Sender, Andrea; Tubasum, Sumera; Vega, Marina Santana; Zhao, Zhengyun; Clark, Alasdair W; Hudson, Andrew J; Eperon, Ian C; Burley, Glenn A; Dominguez, Cyril

Characterizing the protein-protein interaction between MDM2 and 14-3-3σ; proof of concept for small molecule stabilization

表征MDM2和14-3-3σ之间的蛋白质-蛋白质相互作用;小分子稳定化的概念验证

Ward, Jake A; Romartinez-Alonso, Beatriz; Kay, Danielle F; Bellamy-Carter, Jeddidiah; Thurairajah, Bethany; Basran, Jaswir; Kwon, Hanna; Leney, Aneika C; Macip, Salvador; Roversi, Pietro; Muskett, Frederick W; Doveston, Richard G

N-Acyloxymethyl-phthalimides deliver genotoxic formaldehyde to human cells

N-酰氧基甲基邻苯二甲酰亚胺可将具有基因毒性的甲醛输送至人体细胞。

Emms, Vicki L; Lewis, Liam A; Beja, Lilla; Bulman, Natasha F A; Pires, Elisabete; Muskett, Frederick W; McCullagh, James S O; Swift, Lonnie P; McHugh, Peter J; Hopkinson, Richard J

Modulation of IL-17 backbone dynamics reduces receptor affinity and reveals a new inhibitory mechanism.

IL-17骨架动力学的调节降低了受体亲和力,揭示了一种新的抑制机制

Shaw Daniel J, Waters Lorna C, Strong Sarah L, Schulze Monika-Sarah E D, Greetham Gregory M, Towrie Mike, Parker Anthony W, Prosser Christine E, Henry Alistair J, Lawson Alastair D G, Carr Mark D, Taylor Richard J, Hunt Neil T, Muskett Frederick W

Identification, binding, and structural characterization of single domain anti-PD-L1 antibodies inhibitory of immune regulatory proteins PD-1 and CD80

鉴定、结合和结构表征抑制免疫调节蛋白PD-1和CD80的单域抗PD-L1抗体

Kang-Pettinger, Tara; Walker, Kayleigh; Brown, Richard; Cowan, Richard; Wright, Helena; Baravalle, Roberta; Waters, Lorna C; Muskett, Frederick W; Bowler, Matthew W; Sawmynaden, Kovilen; Coombs, Peter J; Carr, Mark D; Hall, Gareth

Biophysical characterisation of the Bcl-x pre-mRNA and binding specificity of the ellipticine derivative GQC-05: Implication for alternative splicing regulation

Bcl-x前体mRNA的生物物理特性及椭圆吡啶衍生物GQC-05的结合特异性:对选择性剪接调控的启示

Bhogadia, Mohammed; Stone, Beth; Del Villar Guerra, Rafael; Muskett, Frederick W; Ghosh, Sudipta; Taladriz-Sender, Andrea; Burley, Glenn A; Eperon, Ian C; Hudson, Andrew J; Dominguez, Cyril

Sequence-specific (1)H, (13)C and (15)N backbone NMR assignments for the N-terminal IgV-like domain (D1) and full extracellular region (D1D2) of PD-L1

PD-L1 的 N 端 IgV 样结构域 (D1) 和完整胞外区 (D1D2) 的序列特异性 (1)H、(13)C 和 (15)N 骨架 NMR 归属

Walker, Kayleigh; Waters, Lorna C; Kelly, Geoff; Muskett, Frederick W; Carr, Mark D

Mass spectrometric detection of KRAS protein mutations using molecular imprinting.

利用分子印迹技术进行KRAS蛋白突变的质谱检测

Norman Rachel L, Singh Rajinder, Muskett Frederick W, Parrott Emma L, Rufini Alessandro, Langridge James I, Runau Franscois, Dennison Ashley, Shaw Jacqui A, Piletska Elena, Canfarotta Francesco, Ng Leong L, Piletsky Sergey, Jones Donald J L

Structural and functional analysis of Dickkopf 4 (Dkk4): New insights into Dkk evolution and regulation of Wnt signaling by Dkk and Kremen proteins.

Dickkopf 4 (Dkk4) 的结构和功能分析:对 Dkk 进化以及 Dkk 和 Kremen 蛋白对 Wnt 信号传导的调控有了新的认识

Patel Saleha, Barkell Alice M, Gupta Deepti, Strong Sarah L, Bruton Shaun, Muskett Frederick W, Addis Philip W, Renshaw Philip S, Slocombe Patrick M, Doyle Carl, Clargo Alison, Taylor Richard J, Prosser Christine E, Henry Alistair J, Robinson Martyn K, Waters Lorna C, Holdsworth Gill, Carr Mark D