日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Controlling Intramolecular Interactions in the Design of Selective, High-Affinity Ligands for the CREBBP Bromodomain

在设计 CREBBP 溴结构域的选择性高亲和力配体时控制分子内相互作用

Michael Brand, James Clayton, Mustafa Moroglu, Matthias Schiedel, Sarah Picaud, Joseph P Bluck, Anna Skwarska, Hannah Bolland, Anthony K N Chan, Corentine M C Laurin, Amy R Scorah, Larissa See, Timothy P C Rooney, Katrina H Andrews, Oleg Fedorov, Gabriella Perell, Prakriti Kalra, Kayla B Vinh, Wilia

BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability

BET 溴结构域配体:探索 WPF 架以提高 BRD4 溴结构域亲和力和代谢稳定性

Laura E Jennings, Matthias Schiedel, David S Hewings, Sarah Picaud, Corentine M C Laurin, Paul A Bruno, Joseph P Bluck, Amy R Scorah, Larissa See, Jessica K Reynolds, Mustafa Moroglu, Ishna N Mistry, Amy Hicks, Pavel Guzanov, James Clayton, Charles N G Evans, Giulia Stazi, Philip C Biggin, Anna K Ma