日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Multiomics Profiling of T-cell Leukemia and Lymphoma Enables Targeted Therapeutic Discovery.

T细胞白血病和淋巴瘤的多组学分析可实现靶向治疗的发现。

Ianevski Aleksandr, Nader Kristen, Nguyen Julia, Sorger Helena, Timonen Sanna, Julia Edith, Pölöske Daniel, Spirk Katrin, Wagner Christina, Jungherz Dennis, Nakano Minoru, Kadambat Nair Sisira, Ianevski Philipp, Kankainen Matti, Dias Diogo, Cichońska Anna, Pemovska Tea, Pirker Christine, Berger Walter, Braun Till, Moriggl Richard, Bachy Emmanuel, Mustjoki Satu, Herling Marco, Neubauer Heidi A, Haibe-Kains Benjamin, Aittokallio Tero

Single-cell genomics highlight MYC-associated metabolic activation and altered cell interactions in T-prolymphocytic leukemia progression

单细胞基因组学揭示了MYC相关的代谢激活和T前淋巴细胞白血病进展中的细胞相互作用改变

Wahnschaffe, Linus; Jungherz, Dennis; Müller, Tony A; Pemovska, Tea; Pichler, Alexander; Poulain, Stéphanie; Julia, Edith; Timonen, Sanna; Böttcher, Martin; Jiang, Qu; Beverungen, David; Bischoff, Julia; Franitza, Marek; Georgomanolis, Theodoros; Becker, Kerstin; Hallek, Michael; Mougiakakos, Dimitrios; Zenz, Thorsten; Mustjoki, Satu; Bachy, Emmanuel; Herbaux, Charles; Schrader, Alexandra; Pflug, Natali; Staber, Philipp B; Braun, Till; Herling, Marco

Leveraging glucan-induced trained immunity for the epigenetic and metabolic rewiring of macrophages to enhance colorectal cancer vaccine response.

利用葡聚糖诱导的训练免疫对巨噬细胞进行表观遗传和代谢重编程,以增强结直肠癌疫苗反应。

Hamdan Firas, Gandolfi Sara, D'Alessio Federica, Giannoula Yvonne, Kolikova Julia, Fusciello Manlio, Zaghen Elisa, Napolano Alessandra, Russo Salvatore, Izci Ozan, Bottega Paolo, Chiaro Jacopo, Alanen Kirsi-Marja, Antignani Gabriella, Feodoroff Michaela, Stigzelius Virpi, Sakalauskaite Milda, Sandberg Janita, Nieminen Anni I, Zambrano Nicola, Eriksson Ove, Mustjoki Satu, Seppälä Toni T, Grönholm Mikaela, Cerullo Vincenzo

Deep cytomorphology identifies erythroid skewing and monocytic morphology to predict TKI sensitivity in CML patients

深度细胞形态学分析可识别红系偏倚和单核细胞形态,从而预测慢性粒细胞白血病患者对酪氨酸激酶抑制剂(TKI)的敏感性。

Luukkainen, Katariina; Purhonen, Mikko; Tatun, Mikael; Hung, Kevin; Tafjord, Oda; Sundquist, Henri; Söderlund, Stina; Adnan-Awad, Shady; Dohlen, Anni; Heikkinen, Johanna; Koskenvesa, Perttu; Joutsi-Korhonen, Lotta; Lempiäinen, Anna; Siitonen, Sanna; Mustjoki, Satu; Shanmuganathan, Naranie; Bryce, Coral; Danielsson, Signe; Hjorth-Hansen, Henrik; Olsson-Strömberg, Ulla; Kumagai, Takashi; Kimura, Shinya; Ross, David M; Brück, Oscar

Multimodal immunopharmacologic screens identify drugs rewiring the cancer-immune interface

多模式免疫药理学筛选可识别重塑癌症-免疫界面的药物。

Bouhlal, Jonas; Jokinen, Emmi; Nygren, Petra; Dias, Diogo; Ianevski, Aleksandr; Klievink, Jay; Lähteenmäki, Hanna; Decombis, Salomé; Duàn, Hanna; Järvelä, Emmi; Saarinen, Emma; Näätänen, Anna; Matjusinski, Konstantin; Kasanen, Tiina; Hannunen, Tiina; Turunen, Laura; Myllymäki, Mikko; Laajala, Essi; Schenkwein, Diana; Ylä-Herttuala, Seppo; Lee, Dean; Korhonen, Matti; Göös, Helka; Aittokallio, Tero; Hollmén, Maija; Mitsiades, Constantine; Gandolfi, Sara; Dufva, Olli; Mustjoki, Satu

High-throughput drug screening identifies SMAC mimetics as enhancers of NK-cell cytotoxicity in chronic myeloid leukemia

高通量药物筛选发现SMAC模拟物可增强慢性粒细胞白血病中NK细胞的细胞毒性。

Nygrén, Petra; Bouhlal, Jonas; Jokinen, Emmi; Forstén, Sofia; Laajala, Essi; Dias, Diogo; Adnan-Awad, Shady; Ianevski, Aleksandr; Klievink, Jay; Lähteenmäki, Hanna; Kuusanmäki, Heikki; Myllymäki, Mikko; Kasanen, Tiina; Saeed, Khalid; Lee, Dean A; Hjorth-Hansen, Henrik; Aittokallio, Tero; Dufva, Olli; Mustjoki, Satu

Inborn errors of immunity underlie clonal T cell expansions in large granular lymphocyte leukemia

先天性免疫缺陷是大颗粒淋巴细胞白血病中克隆性T细胞扩增的根本原因。

Bravo-Perez, Carlos; Gurnari, Carmelo; Huuhtanen, Jani; Kawashima, Naomi; Guarnera, Luca; Mandala, Aashray; Williams, Nakisha D; Haddad, Christopher; Witt, Michaela; Unlu, Serhan; Brady, Zachary; Ogbue, Olisaemeka; Orland, Mark; Ahmed, Arooj; Kubota, Yasuo; Pagliuca, Simona; Durmaz, Arda; Mustjoki, Satu; Visconte, Valeria; Maciejewski, Jaroslaw P

Predicting antigen-specific T-cell immunity against Wilms tumor 1 in hematologic cancer

预测血液肿瘤中针对 Wilms 肿瘤 1 的抗原特异性 T 细胞免疫

Ford, Brittany L; Jokinen, Emmi; Huuhtanen, Jani; Forstén, Sofia; Klievink, Jay; Antignani, Gabriella; Brück, Oscar; Cerullo, Vincenzo; Peltonen, Karita; Mustjoki, Satu

Granulocyte abundance and maturation state at diagnosis predicts treatment-free remission in CML

诊断时粒细胞数量和成熟状态可预测慢性粒细胞白血病患者的无治疗缓解情况。

Purhonen, Mikko; Tatun, Mikael; Luukkainen, Katariina; Hung, Kevin; Sundquist, Henri; Tafjord, Oda; Söderlund, Stina; Adnan-Awad, Shady; Dohlen, Anni; Heikkinen, Johanna; Koskenvesa, Perttu; Siitonen, Sanna; Mustjoki, Satu; Shanmuganathan, Naranie; Bryce, Coral; Danielsson, Signe; Hjorth-Hansen, Henrik; Olsson-Strömberg, Ulla; Kumagai, Takashi; Kimura, Shinya; Ross, David M; Brück, Oscar

Patient-derived tumor explant models of tumor immune microenvironment reveal distinct and reproducible immunotherapy responses.

患者来源的肿瘤外植体模型揭示了肿瘤免疫微环境的独特且可重复的免疫治疗反应

Turpin Rita, Peltonen Karita, Rannikko Jenna H, Liu Ruixian, Kumari Anita N, Nicorici Daniel, Lee Moon Hee, Mutka Minna, Kovanen Panu E, Niinikoski Laura, Meretoja Tuomo, Mattson Johanna, Järvinen Petrus, Lahdensuo Kanerva, Järvinen Riikka, Tornberg Sara, Mirtti Tuomas, Boström Pia, Koskivuo Ilkka, Thotakura Anil, Pouwels Jeroen, Hollmén Maija, Mustjoki Satu, Klefström Juha