日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

FRONTIER-3: a randomised phase 2a study to investigate tozorakimab, an anti-interleukin-33 monoclonal antibody, in early-onset asthma

FRONTIER-3:一项随机 IIa 期研究,旨在研究托佐拉单抗(一种抗白介素-33 单克隆抗体)治疗早发性哮喘的疗效

Corren, Jonathan; Reid, Fred; Moate, Rachel; Jimenez, Eulalia; Sadiq, Muhammad Waqas; Williams, Adam; Rytelewski, Mateusz; Cameron-Christie, Sophia; Muthas, Daniel; Georgi, Benjamin; Brooks, Dennis; Lindqvist, Eva; Kell, Chris; Platt, Adam; Belvisi, Maria G; Pandya, Hitesh

Lung IL-13 gene signatures are associated with raised tissue eosinophils in COPD

肺部IL-13基因特征与慢性阻塞性肺疾病(COPD)患者组织嗜酸性粒细胞增多相关。

Staples, Karl J; Ackland, Jodie; Lukose, Sruthymol; Angermann, Bastian; Belfield, Graham; Belvisi, Maria; Chaerkady, Raghothama; Etal, Damla; Heinson, Ashley; Hess, Sonja; Hristova, Ventzislava A; Hühn, Michael; McCrae, Christopher; Muthas, Daniel; Öberg, Lisa; Ostridge, Kristoffer; Platt, Adam; Spalluto, C Mirella; Watson, Alastair; Wilkinson, Tom

NTHi killing activity is reduced in COPD patients and is associated with a differential microbiome.

慢性阻塞性肺病患者的非典型流感嗜血杆菌(NTHi)杀菌活性降低,且与不同的微生物群有关

Gopalakrishnan Vancheswaran, Sparklin Ben, Kim Jung Hwan, Bouquet Jerome, Kehl Margaret, Kenny Tara, Morehouse Christopher, Caceres Carolina, Warrener Paul, Hristova Ventzislava A, Wilson Susan, Shandilya Harini, Barnes Arnita, Ruzin Alexey, Wang Junmin, Oberg Lisa, Angermann Bastian, McCrae Christopher, Platt Adam, Muthas Daniel, Hess Sonja, Tkaczyk Christine, Sellman Bret R, Ostridge Kristoffer, Belvisi Maria G, Wilkinson Tom M A, Staples Karl J, DiGiandomenico Antonio

Metabolomic profiling of patients with lupus nephritis reveals unique metabolites that are modulated through type I interferon inhibition by anifrolumab treatment in a phase 2 trial

在一项二期临床试验中,对狼疮性肾炎患者进行代谢组学分析发现,阿尼弗鲁单抗治疗可通过抑制I型干扰素来调节独特的代谢物。

Gavin, Patrick G; Allman, Erik L; Jayne, David; Mysler, Eduardo; Amoura, Zahir; Di Poto, Cristina; Tian, Xiang; Hess, Sonja; Csomor, Eszter; Brohawn, Philip Z; Muthas, Daniel; Platt, Adam; Anzillotti, Consuelo; Stone, Heena; Seth, Asha; Woollard, Kevin; Al-Mossawi, Hussein; Lindholm, Catharina; Ferrari, Nicola

Type I interferon blockade with anifrolumab in patients with systemic lupus erythematosus modulates key immunopathological pathways in a gene expression and proteomic analysis of two phase 3 trials

在两项 3 期临床试验中,基因表达和蛋白质组学分析表明,使用阿尼弗鲁单抗阻断 I 型干扰素可调节系统性红斑狼疮患者的关键免疫病理通路。

Baker, Tina; Sharifian, Hoda; Newcombe, Paul J; Gavin, Patrick G; Lazarus, Mark N; Ramaswamy, Madhu; White, Wendy I; Ferrari, Nicola; Muthas, Daniel; Tummala, Raj; Morand, Eric F; Furie, Richard A; Vital, Edward M; Chamberlain, Chris; Platt, Adam; Al-Mossawi, Hussein; Brohawn, Philip Z; Csomor, Eszter

Multiomics links global surfactant dysregulation with airflow obstruction and emphysema in COPD

多组学研究揭示了慢性阻塞性肺疾病中全身表面活性剂失调与气流阻塞和肺气肿之间的关联

Hristova, Ventzislava A; Watson, Alastair; Chaerkady, Raghothama; Glover, Matthew S; Ackland, Jodie; Angerman, Bastian; Belfield, Graham; Belvisi, Maria G; Burke, Hannah; Cellura, Doriana; Clark, Howard W; Etal, Damla; Freeman, Anna; Heinson, Ashley I; Hess, Sonja; Hühn, Michael; Hall, Emily; Mackay, Alex; Madsen, Jens; McCrae, Christopher; Muthas, Daniel; Novick, Steven; Ostridge, Kristoffer; Öberg, Lisa; Platt, Adam; Postle, Anthony D; Spalluto, C Mirella; Vaarala, Outi; Wang, Junmin; Staples, Karl J; Wilkinson, Tom M A

Rare variant contribution to human disease in 281,104 UK Biobank exomes

英国生物银行281104个外显子组中罕见变异对人类疾病的贡献

Wang, Quanli; Dhindsa, Ryan S; Carss, Keren; Harper, Andrew R; Nag, Abhishek; Tachmazidou, Ioanna; Vitsios, Dimitrios; Deevi, Sri V V; Mackay, Alex; Muthas, Daniel; Hühn, Michael; Monkley, Susan; Olsson, Henric; Wasilewski, Sebastian; Smith, Katherine R; March, Ruth; Platt, Adam; Haefliger, Carolina; Petrovski, Slavé

Identification of a missense variant in SPDL1 associated with idiopathic pulmonary fibrosis

鉴定出与特发性肺纤维化相关的SPDL1错义变异

Dhindsa, Ryan S; Mattsson, Johan; Nag, Abhishek; Wang, Quanli; Wain, Louise V; Allen, Richard; Wigmore, Eleanor M; Ibanez, Kristina; Vitsios, Dimitrios; Deevi, Sri V V; Wasilewski, Sebastian; Karlsson, Maria; Lassi, Glenda; Olsson, Henric; Muthas, Daniel; Monkley, Susan; Mackay, Alex; Murray, Lynne; Young, Simon; Haefliger, Carolina; Maher, Toby M; Belvisi, Maria G; Jenkins, Gisli; Molyneaux, Philip L; Platt, Adam; Petrovski, Slavé

Dysregulation of COVID-19 related gene expression in the COPD lung

慢性阻塞性肺病肺部中新冠病毒相关基因表达失调

Watson, Alastair; Öberg, Lisa; Angermann, Bastian; Spalluto, C Mirella; Hühn, Michael; Burke, Hannah; Cellura, Doriana; Freeman, Anna; Muthas, Daniel; Etal, Damla; Belfield, Graham; Karlsson, Fredrik; Nordström, Karl; Ostridge, Kris; Staples, Karl J; Wilkinson, Tom

Fungal Dysbiosis and Intestinal Inflammation in Children With Beta-Cell Autoimmunity

儿童β细胞自身免疫性疾病中的真菌菌群失调和肠道炎症

Honkanen, Jarno; Vuorela, Arja; Muthas, Daniel; Orivuori, Laura; Luopajärvi, Kristiina; Tejesvi, Mysore Vishakante Gowda; Lavrinienko, Anton; Pirttilä, Anna Maria; Fogarty, Christopher L; Härkönen, Taina; Ilonen, Jorma; Ruohtula, Terhi; Knip, Mikael; Koskimäki, Janne J; Vaarala, Outi