日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Intratumoral IL12 mRNA administration activates innate and adaptive pathways in checkpoint inhibitor resistant tumors resulting in complete responses.

肿瘤内注射IL12 mRNA可激活免疫检查点抑制剂耐药肿瘤的先天性和适应性免疫通路,从而产生完全缓解

Lakshmipathi Jayalakshmi, Santha Sreevidya, Li Man, Qian Yuping, Roy Simon F, Luheshi Nadia, Politi Katerina, Bosenberg Marcus, Eyles Jim, Muthusamy Viswanathan

On-target toxicity limits the efficacy of CDK11 inhibition against cancers with 1p36 deletions.

靶向毒性限制了 CDK11 抑制剂对 1p36 缺失癌症的疗效

Julian Linda, Crozier Lisa, Lukow Devon, Mishra Sanat, Swamy Aditi, Hagenson Ryan A, Sennhenn Peter, Sausville Erin L, Mendelson Brianna, Chuaqui Claudio, Qiao Lu, Vasudevan Anand, Lin Kuan-Ting, Bhatia Sonam, Bertomeu Thierry, Chatr-Aryamontri Andrew, Zhang Li, Rees Matthew G, Ronan Melissa M, Roth Jennifer A, Nottoli Timothy, Bai Suxia, Lakshmipathi Jayalakshmi, Muthusamy Viswanathan, Van Vranken Jonathan G, Gygi Steven P, Thompson Sarah L, Smith Joan C, Anderson Kendall, Shah Sanjana, Bindra Ranjit S, Akerman Martin, Spector David L, Krainer Adrian R, Sheltzer Jason M

Comprehensive Analysis of Metabolic Isozyme Targets in Cancer

癌症代谢同工酶靶点的综合分析

Marczyk, Michal; Gunasekharan, Vignesh; Casadevall, David; Qing, Tao; Foldi, Julia; Sehgal, Raghav; Shan, Naing Lin; Blenman, Kim R M; O'Meara, Tess A; Umlauf, Sheila; Surovtseva, Yulia V; Muthusamy, Viswanathan; Rinehart, Jesse; Perry, Rachel J; Kibbey, Richard; Hatzis, Christos; Pusztai, Lajos

Structure-Guided Identification of DNMT3B Inhibitors

基于结构的DNMT3B抑制剂鉴定

Newton, Ana S; Faver, John C; Micevic, Goran; Muthusamy, Viswanathan; Kudalkar, Shalley N; Bertoletti, Nicole; Anderson, Karen S; Bosenberg, Marcus W; Jorgensen, William L

Intratumoral delivery of RIG-I agonist SLR14 induces robust antitumor responses

瘤内注射RIG-I激动剂SLR14可诱导强烈的抗肿瘤反应

Jiang, Xiaodong; Muthusamy, Viswanathan; Fedorova, Olga; Kong, Yong; Kim, Daniel J; Bosenberg, Marcus; Pyle, Anna Marie; Iwasaki, Akiko

Re-engineering the Immune Response to Metastatic Cancer: Antibody-Recruiting Small Molecules Targeting the Urokinase Receptor

重塑针对转移性癌症的免疫反应:靶向尿激酶受体的抗体募集小分子

Rullo, Anthony F; Fitzgerald, Kelly J; Muthusamy, Viswanathan; Liu, Min; Yuan, Cai; Huang, Mingdong; Kim, Minsup; Cho, Art E; Spiegel, David A

DNMT3b Modulates Melanoma Growth by Controlling Levels of mTORC2 Component RICTOR

DNMT3b 通过控制 mTORC2 组分 RICTOR 的水平来调节黑色素瘤的生长

Micevic, Goran; Muthusamy, Viswanathan; Damsky, William; Theodosakis, Nicholas; Liu, Xiaoni; Meeth, Katrina; Wingrove, Emily; Santhanakrishnan, Manjula; Bosenberg, Marcus

Redefining regulation of DNA methylation by RNA interference

RNA干扰对DNA甲基化调控的重新定义

Muthusamy, Viswanathan; Bosenberg, Marcus; Wajapeyee, Narendra