日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting DNA-LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

将DNA-LNP靶向内皮细胞可提高表达强度、持续时间和特异性

Marzolini, Nicolas; Brysgel, Taylor V; Rahman, Ryan J; Essien, Eno-Obong; Nwe, Saw Y; Wu, Jichuan; Majumder, Aparajeeta; Patel, Manthan N; Tiwari, Sachchidanand; Espy, Carolann L; Dong, Fengyi; Santos-De León, Sabrina A; Shah, Anit; Shuvaev, Vladimir V; Hood, Elizabeth D; Chase, Liam S; Weissman, Drew; Katzen, Jeremy B; Frank, David B; Bennett, Mariko L; Marcos-Contreras, Oscar A; Myerson, Jacob W; Muzykantov, Vladimir R; Reyes-Esteves, Sahily; Brenner, Jacob S

Equip your vehicle for the right terrain: Using features of local pathology to guide engineering of targeted drug delivery systems

根据地形选择合适的车辆:利用局部病理特征指导靶向药物输送系统的工程设计

Brysgel, Taylor V; Liu, Jing; Hood, Elizabeth D; Brenner, Jacob S; Muzykantov, Vladimir R

A percolation phase transition controls complement protein coating of surfaces

渗流相变控制着互补蛋白对表面的包覆。

Zhicheng Wang ,Sahil Kulkarni ,Jia Nong ,Marco Zamora ,Alireza Ebrahimimojarad ,Elizabeth Hood ,Tea Shuvaeva ,Michael Zaleski ,Damodar Gullipalli ,Emily Wolfe ,Carolann Espy ,Evguenia Arguiri ,Jichuan Wu ,Yufei Wang ,Oscar A Marcos-Contreras ,Wenchao Song ,Vladimir R Muzykantov ,Jinglin Fu ,Ravi Radhakrishnan ,Jacob W Myerson ,Jacob S Brenner

Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape.

限制内体损伤感知可减少脂质纳米颗粒内体逃逸引发的炎症

Omo-Lamai Serena, Wang Yufei, Patel Manthan N, Milosavljevic Aleksa, Zuschlag Daniel, Poddar Subhajit, Wu Jichuan, Wang Liuqian, Dong Fengyi, Espy Carolann, Majumder Aparajeeta, Essien Eno-Obong, Shen Mengwen, Channer Breana, Papp Tyler E, Tobin Michael, Maheshwari Rhea, Jeong Sumin, Patel Sofia, Shah Anit, Murali Shruthi, Chase Liam S, Zamora Marco E, Arral Mariah L, Marcos-Contreras Oscar A, Myerson Jacob W, Hunter Christopher A, Discher Dennis, Gaskill Peter J, Tsourkas Andrew, Muzykantov Vladimir R, Brodsky Igor, Shin Sunny, Whitehead Kathryn A, Parhiz Hamideh, Katzen Jeremy, Miner Jonathan J, Trauner Dirk, Brenner Jacob S

Conjugation Chemistry Markedly Impacts Toxicity and Biodistribution of Targeted Nanoparticles, Mediated by Complement Activation

结合化学显著影响靶向纳米粒子的毒性和生物分布,由补体激活介导

Michael H Zaleski, Liam S Chase, Elizabeth D Hood, Zhicheng Wang, Jia Nong, Carolann L Espy, Marco E Zamora, Jichuan Wu, Lianne J Morrell, Vladimir R Muzykantov, Jacob W Myerson, Jacob S Brenner

CD47 peptide-cloaked lipid nanoparticles promote cell-specific mRNA delivery

CD47肽包裹的脂质纳米颗粒促进细胞特异性mRNA递送

Papp, Tyler Ellis; Zeng, Jianhao; Shahnawaz, Hamna; Akyianu, Awurama; Breda, Laura; Yadegari, Amir; Steward, Joseph; Shi, Ruiqi; Li, Qin; Mui, Barbara L; Tam, Ying K; Weissman, Drew; Rivella, Stefano; Shuvaev, Vladimir; Muzykantov, Vladimir R; Parhiz, Hamideh

Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo.

将生物治疗性 RNA 系统性输送至心肌可暂时性地调节体内心脏收缩力

Shuvaev Vladimir V, Tam Ying K, Lee Benjamin W, Myerson Jacob W, Herbst Alan, Kiseleva Raisa Yu, Glassman Patrick M, Parhiz Hamideh, Alameh Mohamad-Gabriel, Pardi Norbert, Muramatsu Hiromi, Shuvaeva Tea I, Arguiri Evguenia, Marcos-Contreras Oscar A, Hood Elizabeth D, Brysgel Taylor V, Nong Jia, Papp Tyler E, Eaton Deborah M, Riley Rachel, Palanki Rohan, Musunuru Kiran, Brenner Jacob S, Mitchell Michael J, Ferrari Victor A, Mui Barbara L, Semple Sean C, Weppler Sherry A, Atluri Pavan, Margulies Kenneth B, Weissman Drew, Muzykantov Vladimir R

Red blood cell aggregation within a blood clot causes platelet-independent clot shrinkage

血栓内红细胞聚集会导致血栓发生不依赖于血小板的收缩。

Peshkova, Alina D; Rednikova, Ekaterina K; Khismatullin, Rafael R; Kim, Oleg V; Muzykantov, Vladimir R; Purohit, Prashant K; Litvinov, Rustem I; Weisel, John W

Multi-stage-mixing to control the supramolecular structure of lipid nanoparticles, thereby creating a core-then-shell arrangement that improves performance by orders of magnitude

通过多阶段混合来控制脂质纳米粒子的超分子结构,从而形成核壳结构,使性能提高几个数量级。

Nong, Jia; Gong, Xijing; Dang, Quang Minh; Tiwari, Sachchidanand; Patel, Manthan; Wu, Jichuan; Hanna, Andrew; Park, Wook-Jin; Atochina-Vasserman, Elena N; Huang, Hui-Ting; Marcos-Contreras, Oscar A; Morris-Blanco, Kahlilia C; Miner, Jonathan J; Weissman, Drew; Muzykantov, Vladimir R; Gupta, Kushol; Issadore, David; Myerson, Jacob W; Wang, Zhicheng; Brenner, Jacob S

Physicochemical Targeting of Lipid Nanoparticles to the Lungs Induces Clotting: Mechanisms and Solutions.

脂质纳米颗粒向肺部的物理化学靶向作用可诱导凝血:机制和解决方案

Omo-Lamai Serena, Zamora Marco E, Patel Manthan N, Wu Jichuan, Nong Jia, Wang Zhicheng, Peshkova Alina, Majumder Aparajeeta, Melamed Jilian R, Chase Liam S, Essien Eno-Obong, Weissman Drew, Muzykantov Vladimir R, Marcos-Contreras Oscar A, Myerson Jacob W, Brenner Jacob S