日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain

Patched 1 通过控制甾醇与其胞外富含半胱氨酸结构域的结合来调节 Smoothened 的表达。

Maia Kinnebrew,Rachel E Woolley,T Bertie Ansell,Eamon F X Byrne,Sara Frigui,Giovanni Luchetti,Ria Sircar,Sigrid Nachtergaele,Laurel Mydock-McGrane,Kathiresan Krishnan,Simon Newstead,Mark S P Sansom,Douglas F Covey,Christian Siebold,Rajat Rohatgi

Synthesis and characterization of diazirine alkyne probes for the study of intracellular cholesterol trafficking

用于研究细胞内胆固醇运输的二氮杂环丙烷炔烃探针的合成与表征

McKenna Feltes, Samantha Moores, Sarah E Gale, Kathiresan Krishnan, Laurel Mydock-McGrane, Douglas F Covey, Daniel S Ory, Jean E Schaffer

Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel

胆固醇和神经甾体在五聚体配体门控离子通道上的共同结合位点

Budelier, Melissa M; Cheng, Wayland W L; Chen, Zi-Wei; Bracamontes, John R; Sugasawa, Yusuke; Krishnan, Kathiresan; Mydock-McGrane, Laurel; Covey, Douglas F; Evers, Alex S

Structure-based discovery of glycomimetic FmlH ligands as inhibitors of bacterial adhesion during urinary tract infection

基于结构的糖模拟FmlH配体发现可作为尿路感染期间细菌粘附的抑制剂

Kalas, Vasilios; Hibbing, Michael E; Maddirala, Amarendar Reddy; Chugani, Ryan; Pinkner, Jerome S; Mydock-McGrane, Laurel K; Conover, Matt S; Janetka, James W; Hultgren, Scott J

Rational design strategies for FimH antagonists: new drugs on the horizon for urinary tract infection and Crohn's disease

FimH拮抗剂的合理设计策略:治疗尿路感染和克罗恩病的新药即将问世

Mydock-McGrane, Laurel K; Hannan, Thomas J; Janetka, James W

Structural basis of Smoothened regulation by its extracellular domains

Smoothened 胞外结构域调控的结构基础

Eamon F X Byrne #, Ria Sircar #, Paul S Miller, George Hedger, Giovanni Luchetti, Sigrid Nachtergaele, Mark D Tully, Laurel Mydock-McGrane, Douglas F Covey, Robert P Rambo, Mark S P Sansom, Simon Newstead #, Rajat Rohatgi, Christian Siebold

Development of a bile acid-based newborn screen for Niemann-Pick disease type C

开发基于胆汁酸的新生儿尼曼-匹克病C型筛查方法

Jiang, Xuntian; Sidhu, Rohini; Mydock-McGrane, Laurel; Hsu, Fong-Fu; Covey, Douglas F; Scherrer, David E; Earley, Brian; Gale, Sarah E; Farhat, Nicole Y; Porter, Forbes D; Dietzen, Dennis J; Orsini, Joseph J; Berry-Kravis, Elizabeth; Zhang, Xiaokui; Reunert, Janice; Marquardt, Thorsten; Runz, Heiko; Giugliani, Roberto; Schaffer, Jean E; Ory, Daniel S

Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI

抗毒力异喹诺酮甘露糖苷:优化联芳基苷元以提高其与 FimH 凝集素的结合亲和力和治疗慢性尿路感染的疗效

Jarvis, Cassie; Han, Zhenfu; Kalas, Vasilios; Klein, Roger; Pinkner, Jerome S; Ford, Bradley; Binkley, Jana; Cusumano, Corinne K; Cusumano, Zachary; Mydock-McGrane, Laurel; Hultgren, Scott J; Janetka, James W

Eliminating the roughness in cholesterol's β-face: does it matter?

消除胆固醇β面的粗糙度:这重要吗?

Krause, Martin R; Wang, Minghui; Mydock-McGrane, Laurel; Covey, Douglas F; Tejada, Emmanuel; Almeida, Paulo F; Regen, Steven L

Tracking the subcellular fate of 20(s)-hydroxycholesterol with click chemistry reveals a transport pathway to the Golgi

利用点击化学追踪20(s)-羟基胆固醇的亚细胞命运,揭示了其通往高尔基体的运输途径。

Peyrot, Sara M; Nachtergaele, Sigrid; Luchetti, Giovanni; Mydock-McGrane, Laurel K; Fujiwara, Hideji; Scherrer, David; Jallouk, Andrew; Schlesinger, Paul H; Ory, Daniel S; Covey, Douglas F; Rohatgi, Rajat