日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting DNA-LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity

将DNA-LNP靶向内皮细胞可提高表达强度、持续时间和特异性

Marzolini, Nicolas; Brysgel, Taylor V; Rahman, Ryan J; Essien, Eno-Obong; Nwe, Saw Y; Wu, Jichuan; Majumder, Aparajeeta; Patel, Manthan N; Tiwari, Sachchidanand; Espy, Carolann L; Dong, Fengyi; Santos-De León, Sabrina A; Shah, Anit; Shuvaev, Vladimir V; Hood, Elizabeth D; Chase, Liam S; Weissman, Drew; Katzen, Jeremy B; Frank, David B; Bennett, Mariko L; Marcos-Contreras, Oscar A; Myerson, Jacob W; Muzykantov, Vladimir R; Reyes-Esteves, Sahily; Brenner, Jacob S

A percolation phase transition controls complement protein coating of surfaces

渗流相变控制着互补蛋白对表面的包覆。

Zhicheng Wang ,Sahil Kulkarni ,Jia Nong ,Marco Zamora ,Alireza Ebrahimimojarad ,Elizabeth Hood ,Tea Shuvaeva ,Michael Zaleski ,Damodar Gullipalli ,Emily Wolfe ,Carolann Espy ,Evguenia Arguiri ,Jichuan Wu ,Yufei Wang ,Oscar A Marcos-Contreras ,Wenchao Song ,Vladimir R Muzykantov ,Jinglin Fu ,Ravi Radhakrishnan ,Jacob W Myerson ,Jacob S Brenner

Limiting endosomal damage sensing reduces inflammation triggered by lipid nanoparticle endosomal escape.

限制内体损伤感知可减少脂质纳米颗粒内体逃逸引发的炎症

Omo-Lamai Serena, Wang Yufei, Patel Manthan N, Milosavljevic Aleksa, Zuschlag Daniel, Poddar Subhajit, Wu Jichuan, Wang Liuqian, Dong Fengyi, Espy Carolann, Majumder Aparajeeta, Essien Eno-Obong, Shen Mengwen, Channer Breana, Papp Tyler E, Tobin Michael, Maheshwari Rhea, Jeong Sumin, Patel Sofia, Shah Anit, Murali Shruthi, Chase Liam S, Zamora Marco E, Arral Mariah L, Marcos-Contreras Oscar A, Myerson Jacob W, Hunter Christopher A, Discher Dennis, Gaskill Peter J, Tsourkas Andrew, Muzykantov Vladimir R, Brodsky Igor, Shin Sunny, Whitehead Kathryn A, Parhiz Hamideh, Katzen Jeremy, Miner Jonathan J, Trauner Dirk, Brenner Jacob S

Conjugation Chemistry Markedly Impacts Toxicity and Biodistribution of Targeted Nanoparticles, Mediated by Complement Activation

结合化学显著影响靶向纳米粒子的毒性和生物分布,由补体激活介导

Michael H Zaleski, Liam S Chase, Elizabeth D Hood, Zhicheng Wang, Jia Nong, Carolann L Espy, Marco E Zamora, Jichuan Wu, Lianne J Morrell, Vladimir R Muzykantov, Jacob W Myerson, Jacob S Brenner

Targeted lipid nanoparticles containing IL-10 mRNA improve outcomes in experimental intracerebral hemorrhage

含有IL-10 mRNA的靶向脂质纳米颗粒可改善实验性脑出血的预后

Reyes-Esteves, Sahily; Majumder, Aparajeeta; Marzolini, Nicolas; Zamora, Marco E; Jeong, Soomin; Wang, Yufei; Patel, Manthan N; Espy, Carolann; Papp, Tyler Ellis; Akyianu, Awurama; Nong, Jia; Messe, Lawson; Omo-Lamai, Serena; Parhiz, Hamideh; Myerson, Jacob W; Marcos-Contreras, Oscar A; Brenner, Jacob S

Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo.

将生物治疗性 RNA 系统性输送至心肌可暂时性地调节体内心脏收缩力

Shuvaev Vladimir V, Tam Ying K, Lee Benjamin W, Myerson Jacob W, Herbst Alan, Kiseleva Raisa Yu, Glassman Patrick M, Parhiz Hamideh, Alameh Mohamad-Gabriel, Pardi Norbert, Muramatsu Hiromi, Shuvaeva Tea I, Arguiri Evguenia, Marcos-Contreras Oscar A, Hood Elizabeth D, Brysgel Taylor V, Nong Jia, Papp Tyler E, Eaton Deborah M, Riley Rachel, Palanki Rohan, Musunuru Kiran, Brenner Jacob S, Mitchell Michael J, Ferrari Victor A, Mui Barbara L, Semple Sean C, Weppler Sherry A, Atluri Pavan, Margulies Kenneth B, Weissman Drew, Muzykantov Vladimir R

EXTH-102. Targeting Glioblastoma Immune Evasion with HSV-1 Vectors to Enhance Antigenicity

EXTH-102. 利用HSV-1载体靶向胶质母细胞瘤免疫逃逸以增强抗原性

Marzolini, Nicolas; Brysgel, Taylor V; Rahman, Ryan J; Essien, Eno-Obong; Nwe, Saw Y; Wu, Jichuan; Majumder, Aparajeeta; Patel, Manthan N; Tiwari, Sachchidanand; Espy, Carolann L; Dong, Fengyi; Shah, Anit; Shuvaev, Vladimir V; Hood, Elizabeth D; Chase, Liam S; Weissman, Drew; Katzen, Jeremy B; Frank, David B; Bennett, Mariko L; Marcos-Contreras, Oscar A; Myerson, Jacob W; Muzykantov, Vladimir R; Reyes-Esteves, Sahily; Brenner, Jacob S; Suzuki, Ryoichi; Zixuan, Yan; Ahuja, Ved; Runco, Emerenziana; Chiocca, E Antonio; Nakashima, Hiroshi

Tropomyosin 1 promotes platelet adhesion and clot contraction separate from its roles in developmental hematopoiesis

原肌球蛋白1除了在发育性造血中发挥作用外,还能促进血小板黏附和血凝块收缩。

Kung, Po-Lun; Tsao, Victor; Peshkova, Alina D; Marcos-Contreras, Oscar A; Ha, Kim; Fonar, Gennadiy; Okoli, Nkemdilim; Dulmovits, Brian M; Qiu, Rong; Bates, Rolf D; Yeboah, Janelle; Shalaby, Carson; Truex, Tyler; Jeong, Soomin; Muzykantov, Vladimir R; Myerson, Jacob W; Thom, Christopher S

Multi-stage-mixing to control the supramolecular structure of lipid nanoparticles, thereby creating a core-then-shell arrangement that improves performance by orders of magnitude

通过多阶段混合来控制脂质纳米粒子的超分子结构,从而形成核壳结构,使性能提高几个数量级。

Nong, Jia; Gong, Xijing; Dang, Quang Minh; Tiwari, Sachchidanand; Patel, Manthan; Wu, Jichuan; Hanna, Andrew; Park, Wook-Jin; Atochina-Vasserman, Elena N; Huang, Hui-Ting; Marcos-Contreras, Oscar A; Morris-Blanco, Kahlilia C; Miner, Jonathan J; Weissman, Drew; Muzykantov, Vladimir R; Gupta, Kushol; Issadore, David; Myerson, Jacob W; Wang, Zhicheng; Brenner, Jacob S

Targeted lipid nanoparticles containing IL-10 mRNA improve outcomes in experimental intracerebral hemorrhage.

含有IL-10 mRNA的靶向脂质纳米颗粒可改善实验性脑出血的预后

Reyes-Esteves Sahily, Majumder Aparajeeta, Marzolini Nicolas, Zamora Marco, Wang Yufei, Espy Carolann, Papp Tyler Ellis, Akyianu Awurama, Nong Jia, Messe Lawson, Omo-Lamai Serena, Parhiz Hamideh, Myerson Jacob, Marcos-Contreras Oscar, Brenner Jacob