日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Development of novel ultra-sensitive IL-11 target engagement assays to support mechanistic PK/PD modeling for an anti-IL-11 antibody therapeutic

开发新型超灵敏 IL-11 靶标参与检测，以支持抗 IL-11 抗体治疗的机械 PK/PD 建模

期刊:MAbs
影响因子:5.6
doi:10.1080/19420862.2022.2104153
Maria Myzithras, Siqi Lin, Legairre Radden, Cynthia Hess Kenny, Zheng Cai, Angus MacDonald, Ralph Binetti, Michael Marlow, Paul Fracasso, Glenn Gibson, Christina Bartlett, Julie Hawkins, Steven Hansel
信号转导
发表日期：2022
文献求助 收藏

Retrospective analysis of model-based predictivity of human pharmacokinetics for anti-IL-36R monoclonal antibody MAB92 using a rat anti-mouse IL-36R monoclonal antibody and RNA expression data (FANTOM5).

使用大鼠抗小鼠 IL-36R 单克隆抗体和 RNA 表达数据 (FANTOM5) 对抗 IL-36R 单克隆抗体 MAB92 的人体药代动力学进行基于模型的预测的回顾性分析

期刊:MAbs
影响因子:7.3
doi:10.1080/19420862.2019.1615345
Ahlberg Jennifer, Giragossian Craig, Li Hua, Myzithras Maria, Raymond Ernie, Caviness Gary, Grimaldi Christine, Brown Su-Ellen, Perez Rocio, Yang Danlin, Kroe-Barrett Rachel, Joseph David, Pamulapati Chandrasena, Coble Kelly, Ruus Peter, Woska Joseph R, Ganesan Rajkumar, Hansel Steven, Mbow M Lamine
其它
Human
Mouse
Rat
发表日期：2019
文献求助 收藏

GDF11 Decreases Pressure Overload-Induced Hypertrophy, but Can Cause Severe Cachexia and Premature Death

GDF11可降低压力超负荷诱导的肥大，但可能导致严重恶病质和过早死亡

期刊:Circulation Research
影响因子:16.2
doi:10.1161/CIRCRESAHA.118.312955
Harper, Shavonn C; Johnson, Jaslyn; Borghetti, Giulia; Zhao, Huaqing; Wang, Tao; Wallner, Markus; Kubo, Hajime; Feldsott, Eric A; Yang, Yijun; Joo, Yunichel; Gou, Xinji; Sabri, Abdel Karim; Gupta, Priyanka; Myzithras, Maria; Khalil, Ashraf; Franti, Michael; Houser, Steven R
GDF11
发表日期：2018
文献求助 收藏

Maximizing in vivo target clearance by design of pH-dependent target binding antibodies with altered affinity to FcRn

通过设计对FcRn具有不同亲和力的pH依赖性靶点结合抗体，最大限度地提高体内靶点清除率。

期刊:MAbs
影响因子:5.6
doi:10.1080/19420862.2017.1359455
Danlin Yang，Craig Giragossian，Steven Castellano，Marcio Lasaro，Haiguang Xiao，Himanshu Saraf，Cynthia Hess Kenny，Irina Rybina，Zhong-Fu Huang，Jennifer Ahlberg，Tammy Bigwarfe，Maria Myzithras，Erica Waltz，Simon Roberts，Rachel Kroe-Barrett，Sanjaya Singh
FcRn
发表日期：2017
文献求助 收藏

Utility of immunodeficient mouse models for characterizing the preclinical pharmacokinetics of immunogenic antibody therapeutics.

免疫缺陷小鼠模型在表征免疫原性抗体疗法的临床前药代动力学方面的应用

期刊:MAbs
影响因子:7.3
doi:10.1080/19420862.2016.1229721
Myzithras Maria, Bigwarfe Tammy, Li Hua, Waltz Erica, Ahlberg Jennifer, Giragossian Craig, Roberts Simon
免疫/内分泌
Mouse
发表日期：2016
文献求助 收藏

GDF11 does not rescue aging-related pathological hypertrophy

GDF11 不能挽救与衰老相关的病理性肥大

期刊:Circulation Research
影响因子:16.2
doi:10.1161/CIRCRESAHA.115.307527
Smith, Shavonn C; Zhang, Xiaoxiao; Zhang, Xiaoying; Gross, Polina; Starosta, Timothy; Mohsin, Sadia; Franti, Michael; Gupta, Priyanka; Hayes, David; Myzithras, Maria; Kahn, Julius; Tanner, James; Weldon, Steven M; Khalil, Ashraf; Guo, Xinji; Sabri, Abdelkarim; Chen, Xiongwen; MacDonnell, Scott; Houser, Steven R
衰老
GDF11
发表日期：2015
文献求助 收藏