PIK3CA(H1047R)- and Her2-initiated mammary tumors escape PI3K dependency by compensatory activation of MEK-ERK signaling
PIK3CA(H1047R)和 Her2 引发的乳腺肿瘤通过补偿性激活 MEK-ERK 信号传导摆脱 PI3K 依赖性
期刊:Oncogene
影响因子:6.9
doi:10.1038/onc.2015.377
H Cheng, P Liu, C Ohlson, E Xu, L Symonds, A Isabella, W J Muller, N U Lin, I E Krop, T M Roberts, E P Winer, C L Arteaga, J J Zhao
信号转导
肿瘤
乳腺癌
MAPK/ERK
PI3K/Akt