Nada Hossam相关文献与解析，生知库 | 链接生命科学的每一步

日期影响因子

Overcoming the undruggable barrier: Structure-guided discovery of a potent small molecule CD28 antagonist with translational potential

克服“不可成药”障碍：基于结构的CD28小分子拮抗剂的发现及其转化潜力

期刊:Biomedicine & Pharmacotherapy

影响因子:7.5

doi:10.1016/j.biopha.2025.118937

Upadhyay, Saurabh; Nada, Hossam; Cho, Sungwoo; Gabr, Moustafa T

发表日期：2026

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TREM2 activation by first-in-class direct small molecule agonists: DEL screening, optimization, biophysical validation, and functional characterization

首创直接小分子激动剂激活TREM2：DEL筛选、优化、生物物理验证和功能表征

期刊:European Journal of Medicinal Chemistry

影响因子:5.9

doi:10.1016/j.ejmech.2025.118358

Nada, Hossam; Yuan, Shaoren; El Gaamouch, Farida; Cho, Sungwoo; Kuncewicz, Katarzyna; Calvo-Barreiro, Laura; Gabr, Moustafa T

发表日期：2026

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Exploiting NMR Ensemble Heterogeneity Enables Small Molecule Discovery Against Dynamic Protein-Protein Interfaces

利用核磁共振谱系异质性实现针对动态蛋白质-蛋白质界面的小分子发现

doi:10.64898/2026.02.04.703700

Nada, Hossam; Cho, Sungwoo; Abdo, Ashraf N; Gabr, Moustafa

发表日期：2026

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Targeting CHI3L1 in Alzheimer's Disease: Optimization of G721-0282 and Functional Evaluation in Astrocyte Models

靶向 CHI3L1 治疗阿尔茨海默病：G721-0282 的优化及在星形胶质细胞模型中的功能评价

doi:10.64898/2026.01.13.699206

Kaur, Baljit; Nada, Hossam; Zhang, Longfei; Gabr, Moustafa

阿尔茨海默症

细胞生物学

发表日期：2026

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First-in-Class Small Molecule ROBO2 Binders Identified through Integrated Virtual Screening and Biophysical Validation

通过整合虚拟筛选和生物物理验证，鉴定出首创的小分子ROBO2结合剂

doi:10.64898/2026.01.05.697640

Upmanyu, Kirti; Nada, Hossam; Gabr, Moustafa T

发表日期：2026

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Small Molecule Agonists of TREM2 Reprogram Microglia and Protect Synapses in Human Alzheimer's Models

TREM2小分子激动剂可重编程小胶质细胞并保护人类阿尔茨海默病模型中的突触

doi:10.64898/2026.01.19.700278

Nada, Hossam; Yuan, Shaoren; Gaamouch, Farida El; Cho, Sungwoo; Gabr, Moustafa T

阿尔茨海默症

细胞生物学

发表日期：2026

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Discovery of MA48, a Small Molecule Inhibitor of CAPON (NOS1AP)-NOS1 Protein-Protein Interaction

MA48 的发现，是一种 CAPON (NOS1AP)-NOS1 蛋白-蛋白相互作用的小分子抑制剂。

doi:10.64898/2026.02.21.707155

Abdo, Ashraf; Nada, Hossam; Gabr, Moustafa

发表日期：2026

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As48, a first-in-class dual-function TREM2 modulator: Receptor activation and shedding inhibition

As48，一种首创的双功能TREM2调节剂：受体激活和脱落抑制

期刊:Biomedicine & Pharmacotherapy

影响因子:7.5

doi:10.1016/j.biopha.2025.118862

Cho, Sungwoo; El Gaamouch, Farida; Upadhyay, Saurabh; Nada, Hossam; Kuncewicz, Katarzyna; Gabr, Moustafa T

发表日期：2025

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CHI3L1-targeted small molecules as glioblastoma therapies: Virtual screening-based discovery, biophysical validation, pharmacokinetic profiling, and evaluation in glioblastoma spheroids.

以 CHI3L1 为靶点的小分子作为胶质母细胞瘤疗法：基于虚拟筛选的发现、生物物理验证、药代动力学分析和在胶质母细胞瘤球体中的评估

期刊:European Journal of Medicinal Chemistry

影响因子:5.9

doi:10.1016/j.ejmech.2025.117960

Nada Hossam, Zhang Longfei, Kaur Baljit, Gabr Moustafa T

细胞生物学

发表日期：2025

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LMT2368 (1-(4-Chlorophenyl)-3-(3-fluoro-5-(trifluoromethyl)phenyl)urea) Negatively Regulates Inflammation by Inhibiting NLRP3 Inflammasome Activation.

LMT2368（1-(4-氯苯基)-3-(3-氟-5-(三氟甲基)苯基)脲）通过抑制NLRP3炎症小体激活来负向调节炎症。

期刊:Pharmaceutics

影响因子:5.5

doi:10.3390/pharmaceutics17101241

Nguyen Thai Uy, Kwon Su Jeong, Hurh Sunghoon, Kale Ashok, Cho Jae Min, Nada Hossam, Kim Chang Seong, Induvadana Peela, Park Beom Jin, Lee Kyeong, Choi Yongseok, Hwang Jong-Ik

Immunology/Inflammation

发表日期：2025

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