日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A brain-penetrant P2X7R antagonist mitigates Alzheimer's disease pathology

一种能穿透血脑屏障的P2X7R拮抗剂可减轻阿尔茨海默病病理。

Turcu, Andreea L; Oken, Adam C; Griñán-Ferré, Christian; Durner, Anna; Sierra-Marquez, Juan; Hinz-Kowalik, Sonja; Nagel, Jessica; Lee, So-Deok; Tzortzini, Efpraxia; Georgiou, Kyriakos; Bhol, Mamina; Baz, Zuriñe; Llop, Jordi; Schneider, Marion; Barbaraci, Carla; Kim, Ga-Ram; Barniol-Xicota, Marta; Val, Cristina; Brea, José; Loza, M Isabel; Pérez, Belén; Naesens, Lieve; Kolocouris, Antonios; Kim, Yong-Chul; Müller, Christa E; Nicke, Annette; Pallàs, Mercè; Mansoor, Steven E; Vázquez, Santiago

A coronavirus assembly inhibitor that targets the viral membrane protein.

一种针对病毒膜蛋白的冠状病毒组装抑制剂

Laporte Manon, Jochmans Dirk, Bardiot Dorothée, Desmarets Lowiese, Debski-Antoniak Oliver J, Mizzon Giulia, Abdelnabi Rana, Leyssen Pieter, Chiu Winston, Zhang Zhikuan, Nomura Norimichi, Boland Sandro, Ohto Umeharu, Stahl Yannick, Wuyts Jurgen, De Jonghe Steven, Stevaert Annelies, van Hemert Martijn J, Bontes Brenda W, Wanningen Patrick, Groenewold G J Mirjam, Zegar Aneta, Owczarek Katarzyna, Joshi Sanjata, Koukni Mohamed, Arzel Philippe, Klaassen Hugo, Vanherck Jean-Christophe, Vandecaetsbeek Ilse, Cremers Niels, Donckers Kim, Francken Thibault, Van Buyten Tina, Rymenants Jasper, Schepers Joost, Pyrc Krzysztof, Hilgenfeld Rolf, Dubuisson Jean, Bosch Berend-Jan, Van Kuppeveld Frank, Eydoux Cecilia, Decroly Etienne, Canard Bruno, Naesens Lieve, Weynand Birgit, Snijder Eric J, Belouzard Sandrine, Shimizu Toshiyuki, Bartenschlager Ralf, Hurdiss Daniel L, Marchand Arnaud, Chaltin Patrick, Neyts Johan

Trypstatin as a Novel TMPRSS2 Inhibitor with Broad-Spectrum Efficacy against Corona and Influenza Viruses.

胰蛋白酶抑制剂作为一种新型TMPRSS2抑制剂,对冠状病毒和流感病毒具有广谱疗效

Lawrenz Jan, Wettstein Lukas, Rodríguez Alfonso Armando, Nchioua Rayhane, von Maltitz Pascal, Albers Dan Pascal Jean, Zech Fabian, Vandeput Julie, Naesens Lieve, Fois Giorgio, Neubauer Veronika, Preising Nico, Schmierer Emilia, Almeida-Hernandez Yasser, Petersen Moritz, Ständker Ludger, Wiese Sebastian, Braubach Peter, Frick Manfred, Barth Eberhard, Sauter Daniel, Kirchhoff Frank, Sanchez-Garcia Elsa, Stevaert Annelies, Münch Jan

A guanidine-based coronavirus replication inhibitor which targets the nsp15 endoribonuclease and selects for interferon-susceptible mutant viruses

一种基于胍的冠状病毒复制抑制剂,靶向nsp15核糖核酸内切酶,并筛选出对干扰素敏感的突变病毒。

Van Loy, Benjamin; Pujol, Eugènia; Kamata, Kenichi; Lee, Xiao Yin; Bakirtzoglou, Nikolai; Van Berwaer, Ria; Vandeput, Julie; Mestdagh, Cato; Persoons, Leentje; De Wijngaert, Brent; Goovaerts, Quinten; Noppen, Sam; Jacquemyn, Maarten; Ahmadzadeh, Kourosh; Bernaerts, Eline; Martín-López, Juan; Escriche, Celia; Vanmechelen, Bert; Krasniqi, Besir; Singh, Abhimanyu K; Daelemans, Dirk; Maes, Piet; Matthys, Patrick; Dehaen, Wim; Rozenski, Jef; Das, Kalyan; Voet, Arnout; Vázquez, Santiago; Naesens, Lieve; Stevaert, Annelies

Profiling Bacteria in the Lungs of Patients with Severe Influenza Versus COVID-19 with or without Aspergillosis

对重症流感患者与伴或不伴曲霉病的 COVID-19 患者肺部细菌进行分析

Feys, Simon; Cardinali-Benigni, Martina; Lauwers, Hanne Moon; Jacobs, Cato; Stevaert, Annelies; Gonçalves, Samuel M; Cunha, Cristina; Debaveye, Yves; Hermans, Greet; Heylen, Jannes; Humblet-Baron, Stephanie; Lagrou, Katrien; Maessen, Lenn; Meersseman, Philippe; Peetermans, Marijke; Redondo-Rios, Alvaro; Seldeslachts, Laura; Starick, Marick R; Thevissen, Karin; Vande Velde, Greetje; Vandenbriele, Christophe; Vanderbeke, Lore; Wilmer, Alexander; Naesens, Lieve; van de Veerdonk, Frank L; Van Weyenbergh, Johan; Gabaldón, Toni; Wauters, Joost; Carvalho, Agostinho

One-pot synthesis, characterization and antiviral properties of new benzenesulfonamide-based spirothiazolidinones

新型苯磺酰胺基螺噻唑烷酮的一锅法合成、表征及抗病毒性能

Apaydın, Çağla Begüm; Naesens, Lieve; Cihan-Üstündağ, Gökçe

Novel pentafluorosulfanyl-containing triclocarban analogs selectively kill Gram-positive bacteria

新型含五氟硫基的三氯卡班类似物可选择性杀灭革兰氏阳性菌

Pormohammad, Ali; Moradi, Melika; Hommes, Josefien W; Pujol, Eugènia; Naesens, Lieve; Vázquez, Santiago; Surewaard, Bas G J; Zarei, Mohammad; Vazquez-Carrera, Manuel; Turner, Raymond J

Nucleoside analogs for management of respiratory virus infections: mechanism of action and clinical efficacy

核苷类似物治疗呼吸道病毒感染:作用机制和临床疗效

Stevaert, Annelies; Groaz, Elisabetta; Naesens, Lieve

Early oseltamivir reduces risk for influenza-associated aspergillosis in a double-hit murine model

在双重打击小鼠模型中,早期使用奥司他韦可降低流感相关曲霉病的风险。

Seldeslachts, Laura; Vanderbeke, Lore; Fremau, Astrid; Reséndiz-Sharpe, Agustin; Jacobs, Cato; Laeveren, Bo; Ostyn, Tessa; Naesens, Lieve; Brock, Matthias; Van De Veerdonk, Frank L; Humblet-Baron, Stephanie; Verbeken, Erik; Lagrou, Katrien; Wauters, Joost; Vande Velde, Greetje

The SARS-CoV-2 and other human coronavirus spike proteins are fine-tuned towards temperature and proteases of the human airways

SARS-CoV-2 和其他人类冠状病毒的刺突蛋白都经过精细调节,以适应人类呼吸道的温度和蛋白酶。

Laporte, Manon; Raeymaekers, Valerie; Van Berwaer, Ria; Vandeput, Julie; Marchand-Casas, Isabel; Thibaut, Hendrik-Jan; Van Looveren, Dominique; Martens, Katleen; Hoffmann, Markus; Maes, Piet; Pöhlmann, Stefan; Naesens, Lieve; Stevaert, Annelies