Naisbitt相关文献与解析，生知库 | 链接生命科学的每一步

Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial

生物标志物指导疑似脓毒症住院患者的抗生素疗程：ADAPT-脓毒症随机临床试验

期刊:Journal of the American Medical Association

doi:10.1001/jama.2024.26458

Dark, Paul; Hossain, Anower; McAuley, Daniel F; Brealey, David; Carlson, Gordon; Clayton, Jonathan C; Felton, Timothy W; Ghuman, Belinder K; Gordon, Anthony C; Hellyer, Thomas P; Lone, Nazir I; Manazar, Uzma; Richards, Gillian; McCullagh, Iain J; McMullan, Ronan; McNamee, James J; McNeil, Hannah C; Mouncey, Paul R; Naisbitt, Micheal J; Parker, Robert J; Poole, Ruth L; Rostron, Anthony J; Singer, Mervyn; Stevenson, Matt D; Walsh, Tim S; Welters, Ingeborg D; Whitehouse, Tony; Whiteley, Simon; Wilson, Peter; Young, Keith K; Perkins, Gavin D; Lall, Ranjit

TSC22 domain family member 3 links natural killer cells to CD8+ T cell-mediated drug hypersensitivity

TSC22结构域家族成员3将自然杀伤细胞与CD8+ T细胞介导的药物超敏反应联系起来

期刊:Signal Transduction and Targeted Therapy

影响因子:52.7

doi:10.1038/s41392-025-02300-0

Sun, Lele; Huai, Pengcheng; Wang, Zhenzhen; Zhao, Qing; Lin, Yingjie; Liu, Tingting; Xue, Xiaotong; Ao, Suiting; You, Jiabao; Sun, Yonghu; Mi, Zihao; Gardner, Joshua; Thomson, Paul J; Naisbitt, Dean J; Meng, Xiaoli; Liu, Jianjun; Liu, Hong; Zhang, Furen

Feedback regulation of VISTA and Treg by TNF-α controls T cell responses in drug allergy

TNF-α对VISTA和Treg的反馈调节控制药物过敏中的T细胞反应

期刊:Allergy

影响因子:12

doi:10.1111/all.16393

Sun, Lele; Zhao, Qing; Ao, Suiting; Liu, Tingting; Wang, Zhenzhen; You, Jiabao; Mi, Zihao; Sun, Yonghu; Xue, Xiaotong; Ogese, Monday O; Gardner, Joshua; Meng, Xiaoli; Naisbitt, Dean J; Liu, Hong; Zhang, Furen

Tolvaptan safety in autosomal-dominant polycystic kidney disease; a focus on idiosyncratic drug-induced liver injury liabilities

托伐普坦在常染色体显性多囊肾病中的安全性；重点关注特异性药物性肝损伤风险

期刊:Toxicological Sciences

影响因子:4.1

doi:10.1093/toxsci/kfae142

Hammond, Sean; Meng, Xiaoli; Barber, Jane; Mosedale, Merrie; Chadwick, Amy; Watkins, Paul B; Naisbitt, Dean J

Elucidating CD4+ and CD8+ T-cell involvement in patients with vancomycin-induced DRESS

阐明 CD4+ 和 CD8+ T 细胞在万古霉素诱导的药物反应伴嗜酸性粒细胞增多和全身症状 (DRESS) 患者中的作用。

期刊:Toxicological Sciences

影响因子:4.1

doi:10.1093/toxsci/kfaf074

Gardner, Joshua; Martinez-Rivera, Silvia; Line, James; Thomson, Paul; Clarke, Elsie; Gibson, Andrew; Krantz, Matthew S; Ardern-Jones, Michael; Phillips, Elizabeth J; Naisbitt, Dean J

Bioactivation of the β-Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor Atabecestat Leads to Protein Adduct Formation on Glutathione S-Transferase Pi

β-淀粉样蛋白前体裂解酶1抑制剂阿他贝司他（Atabecestat）的生物活化导致谷胱甘肽S-转移酶Pi上蛋白质加合物的形成。

期刊:Chemical Research in Toxicology

影响因子:3.8

doi:10.1021/acs.chemrestox.5c00070

Ford, Megan; Thomson, Paul J; Lister, Adam; Snoeys, Jan; Leclercq, Laurent; Cuyckens, Filip; Naisbitt, Dean J; Meng, Xiaoli

发表日期：2025

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Intratumoral antigen signaling traps CD8(+) T cells to confine exhaustion to the tumor site

肿瘤内抗原信号传导会捕获 CD8(+) T 细胞，从而将 T 细胞耗竭限制在肿瘤部位。

期刊:Science Immunology

影响因子:16.3

doi:10.1126/sciimmunol.ade2094

Takahashi, Munetomo; So, Tsz Y; Chamberlain-Evans, Vitalina; Hughes, Robert; Yam-Puc, Juan Carlos; Kania, Katarzyna; Ruhle, Michelle; Mann, Tiffeney; Schuijs, Martijn J; Coupland, Paul; Naisbitt, Dean; Halim, Timotheus Y F; Lyons, Paul A; Lio, Pietro; Roychoudhuri, Rahul; Okkenhaug, Klaus; Adams, David J; Smith, Ken G C; Jodrell, Duncan I; Chapman, Michael A; Thaventhiran, James E D

Patients with naproxen-induced liver injury display T-cell memory responses toward an oxidative (S)-O-desmethyl naproxen metabolite but not the acyl glucuronide

萘普生引起的肝损伤患者对萘普生的氧化代谢产物(S)-O-去甲基代谢物表现出T细胞记忆反应，但对酰基葡糖醛酸苷则无反应。

期刊:Allergy

影响因子:12

doi:10.1111/all.15830

Thomson, Paul; Fragkas, Nik; Kafu, Laila M; Aithal, Guruprasad P; Lucena, M Isabel; Terracciano, Luigi; Meng, Xiaoli; Pirmohamed, Munir; Brees, Dominique; Kullak-Ublick, Gerd A; Odermatt, Alex; Hammond, Thomas; Kammüller, Michael; Naisbitt, Dean J

Identification of cross reactive T cell responses in adenovirus based COVID 19 vaccines

腺病毒载体新冠疫苗中交叉反应性T细胞应答的鉴定

期刊:NPJ Vaccines

影响因子:6.9

doi:10.1038/s41541-024-00895-z

Joshua Gardner ，Simon Timothy Abrams ，Cheng-Hock Toh ，Alan L Parker ，Charlotte Lovatt ，Phillip L R Nicolson ，Steve P Watson ，Sophie Grice ，Luisa Hering ，Munir Pirmohamed ，Dean J Naisbitt

Insights into the Biochemical and Immune Mechanisms in Drug-Induced Liver Injury Pathogenesis

药物性肝损伤发病机制中生化和免疫机制的深入研究

Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial

生物标志物指导疑似脓毒症住院患者的抗生素疗程：ADAPT-脓毒症随机临床试验

TSC22 domain family member 3 links natural killer cells to CD8+ T cell-mediated drug hypersensitivity

TSC22结构域家族成员3将自然杀伤细胞与CD8+ T细胞介导的药物超敏反应联系起来

Feedback regulation of VISTA and Treg by TNF-α controls T cell responses in drug allergy

TNF-α对VISTA和Treg的反馈调节控制药物过敏中的T细胞反应

Tolvaptan safety in autosomal-dominant polycystic kidney disease; a focus on idiosyncratic drug-induced liver injury liabilities

托伐普坦在常染色体显性多囊肾病中的安全性；重点关注特异性药物性肝损伤风险

Elucidating CD4+ and CD8+ T-cell involvement in patients with vancomycin-induced DRESS

阐明 CD4+ 和 CD8+ T 细胞在万古霉素诱导的药物反应伴嗜酸性粒细胞增多和全身症状 (DRESS) 患者中的作用。

Bioactivation of the β-Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor Atabecestat Leads to Protein Adduct Formation on Glutathione S-Transferase Pi

β-淀粉样蛋白前体裂解酶1抑制剂阿他贝司他（Atabecestat）的生物活化导致谷胱甘肽S-转移酶Pi上蛋白质加合物的形成。

Intratumoral antigen signaling traps CD8(+) T cells to confine exhaustion to the tumor site

肿瘤内抗原信号传导会捕获 CD8(+) T 细胞，从而将 T 细胞耗竭限制在肿瘤部位。

Patients with naproxen-induced liver injury display T-cell memory responses toward an oxidative (S)-O-desmethyl naproxen metabolite but not the acyl glucuronide

萘普生引起的肝损伤患者对萘普生的氧化代谢产物(S)-O-去甲基代谢物表现出T细胞记忆反应，但对酰基葡糖醛酸苷则无反应。

Identification of cross reactive T cell responses in adenovirus based COVID 19 vaccines

腺病毒载体新冠疫苗中交叉反应性T细胞应答的鉴定