日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Metabolic reprogramming regulated by TRAF6 contributes to the leukemia progression

TRAF6调控的代谢重编程促进白血病进展

Shinichiro Matsui ,Chihiro Ri ,Lyndsey C Bolanos ,Kwangmin Choi ,Asuka Shibamiya ,Arata Ishii ,Koji Takaishi ,Nagisa Oshima-Hasegawa ,Shokichi Tsukamoto ,Yusuke Takeda ,Naoya Mimura ,Akihide Yoshimi ,Koutaro Yokote ,Daniel T Starczynowski ,Emiko Sakaida ,Tomoya Muto

DHODH inhibition synergizes with DNA-demethylating agents in the treatment of myelodysplastic syndromes

DHODH 抑制剂与 DNA 去甲基化剂协同作用治疗骨髓增生异常综合征

Kensuke Kayamori, Yurie Nagai, Cheng Zhong, Satoshi Kaito, Daisuke Shinoda, Shuhei Koide, Wakako Kuribayashi, Motohiko Oshima, Yaeko Nakajima-Takagi, Masayuki Yamashita, Naoya Mimura, Hans Jiro Becker, Kiyoko Izawa, Satoshi Yamazaki, Satoshi Iwano, Atsushi Miyawaki, Ryoji Ito, Kaoru Tohyama, William

The combination of the tubulin binding small molecule PTC596 and proteasome inhibitors suppresses the growth of myeloma cells

微管蛋白结合小分子 PTC596 与蛋白酶体抑制剂的联合作用可抑制骨髓瘤细胞的生长

Yurie Nagai, Naoya Mimura, Ola Rizq, Yusuke Isshiki, Motohiko Oshima, Mohamed Rizk, Atsunori Saraya, Shuhei Koide, Yaeko Nakajima-Takagi, Makiko Miyota, Tetsuhiro Chiba, Nagisa Oshima-Hasegawa, Tomoya Muto, Shokichi Tsukamoto, Shio Mitsukawa, Yusuke Takeda, Chikako Ohwada, Masahiro Takeuchi, Tohru I

p53-related protein kinase confers poor prognosis and represents a novel therapeutic target in multiple myeloma

p53 相关蛋白激酶预后不良并代表多发性骨髓瘤的新治疗靶点

Teru Hideshima, Francesca Cottini, Yoshihisa Nozawa, Hyuk-Soo Seo, Hiroto Ohguchi, Mehmet K Samur, Diana Cirstea, Naoya Mimura, Yoshikazu Iwasawa, Paul G Richardson, Nikhil C Munshi, Dharminder Chauhan, Walter Massefski, Teruhiro Utsugi, Sirano Dhe-Paganon, Kenneth C Anderson

Dual Inhibition of EZH2 and EZH1 Sensitizes PRC2-Dependent Tumors to Proteasome Inhibition

EZH2 和 EZH1 的双重抑制使 PRC2 依赖性肿瘤对蛋白酶体抑制敏感

Ola Rizq, Naoya Mimura, Motohiko Oshima, Atsunori Saraya, Shuhei Koide, Yuko Kato, Kazumasa Aoyama, Yaeko Nakajima-Takagi, Changshan Wang, Tetsuhiro Chiba, Anqi Ma, Jian Jin, Tohru Iseki, Chiaki Nakaseko, Atsushi Iwama

HDAC6 inhibitor WT161 downregulates growth factor receptors in breast cancer

HDAC6 抑制剂 WT161 下调乳腺癌中的生长因子受体

Teru Hideshima, Ralph Mazitschek, Jun Qi, Naoya Mimura, Jen-Chieh Tseng, Andrew L Kung, James E Bradner, Kenneth C Anderson

Possible role of intragenic DNA hypermethylation in gene silencing of the tumor suppressor gene NR4A3 in acute myeloid leukemia

基因内 DNA 高甲基化在急性髓系白血病中肿瘤抑制基因 NR4A3 基因沉默中的可能作用

Ryo Shimizu, Tomoya Muto, Kazumasa Aoyama, Kwangmin Choi, Masahiro Takeuchi, Shuhei Koide, Nagisa Hasegawa, Yusuke Isshiki, Emi Togasaki, Chika Kawajiri-Manako, Yuhei Nagao, Shokichi Tsukamoto, Shio Sakai, Yusuke Takeda, Naoya Mimura, Chikako Ohwada, Emiko Sakaida, Tohru Iseki, Daniel T Starczynowsk

Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma

发现选择性小分子 HDAC6 抑制剂,可克服多发性骨髓瘤中的蛋白酶体抑制剂耐药性

Teru Hideshima, Jun Qi, Ronald M Paranal, Weiping Tang, Edward Greenberg, Nathan West, Meaghan E Colling, Guillermina Estiu, Ralph Mazitschek, Jennifer A Perry, Hiroto Ohguchi, Francesca Cottini, Naoya Mimura, Güllü Görgün, Yu-Tzu Tai, Paul G Richardson, Ruben D Carrasco, Olaf Wiest, Stuart L Schrei

Combination of a Selective HSP90α/β Inhibitor and a RAS-RAF-MEK-ERK Signaling Pathway Inhibitor Triggers Synergistic Cytotoxicity in Multiple Myeloma Cells

选择性 HSP90α/β 抑制剂与 RAS-RAF-MEK-ERK 信号通路抑制剂联合使用可在多发性骨髓瘤细胞中引发协同细胞毒性

Rikio Suzuki, Shohei Kikuchi, Takeshi Harada, Naoya Mimura, Jiro Minami, Hiroto Ohguchi, Yasuhiro Yoshida, Morihiko Sagawa, Gullu Gorgun, Diana Cirstea, Francesca Cottini, Jana Jakubikova, Yu-Tzu Tai, Dharminder Chauhan, Paul G Richardson, Nikhil Munshi, Kiyoshi Ando, Teruhiro Utsugi, Teru Hideshima

Selective and potent Akt inhibition triggers anti-myeloma activities and enhances fatal endoplasmic reticulum stress induced by proteasome inhibition

选择性和有效的 Akt 抑制可触发抗骨髓瘤活性并增强蛋白酶体抑制引起的致命内质网应激

Naoya Mimura, Teru Hideshima, Toshiyasu Shimomura, Rikio Suzuki, Hiroto Ohguchi, Ola Rizq, Shohei Kikuchi, Yasuhiro Yoshida, Francesca Cottini, Jana Jakubikova, Diana Cirstea, Gullu Gorgun, Jiro Minami, Yu-Tzu Tai, Paul G Richardson, Teruhiro Utsugi, Atsushi Iwama, Kenneth C Anderson