Investigation of anomalous charge variant profile reveals discrete pH-dependent conformations and conformation-dependent charge states within the CDR3 loop of a therapeutic mAb
对异常电荷变体谱的研究揭示了治疗性 mAb 的 CDR3 环内离散的 pH 依赖性构象和构象依赖性电荷状态
期刊:MAbs
影响因子:5.6
doi:10.1080/19420862.2020.1763138
Wenkui Lan, Joseph J Valente, Andrew Ilott, Naresh Chennamsetty, Zhihua Liu, Joseph M Rizzo, Aaron P Yamniuk, Difei Qiu, Holly M Shackman, Mark S Bolgar
